STRINGSTRING
TNMD TNMD MMRN2 MMRN2 JUN JUN LOC102185958 LOC102185958 KDR KDR ATP5IF1 ATP5IF1 PROK1 PROK1 PDCD6 PDCD6 LOC102188312 LOC102188312 FGFBP1 FGFBP1 LOC102183240 LOC102183240 TNF TNF VEGFA VEGFA NR4A1 NR4A1 STAT1 STAT1 NRARP NRARP RNASE4 RNASE4 SCG2 SCG2 CCL24 CCL24 NF1 NF1 ECM1 ECM1 SIRT1 SIRT1 FGFR1 FGFR1 CDH13 CDH13 ATOH8 ATOH8 AGTR1 AGTR1 ENSCHIP00000008714 ENSCHIP00000008714 CNMD CNMD VASH2 VASH2 PLXNB3 PLXNB3 TBC1D31 TBC1D31 PPP1R16B PPP1R16B AGGF1 AGGF1 FGF10 FGF10 SP1 SP1 BMP2 BMP2 CCL11 CCL11 CAV2 CAV2 PDCL3 PDCL3 TIE1 TIE1 JCAD JCAD ADAM17 ADAM17 FLT4 FLT4 ENSCHIP00000011995 ENSCHIP00000011995 FUT2 FUT2 ATP5F1A ATP5F1A VASH1 VASH1 PTPRM PTPRM DBH DBH VIP VIP PDPK1 PDPK1 DLL4 DLL4 FGF7 FGF7 EMC10 EMC10 WNT5A WNT5A MEF2C MEF2C HMOX1 HMOX1 MYDGF MYDGF IL12B IL12B LRG1 LRG1 XDH XDH PRKD1 PRKD1 THBS1 THBS1 ITGB3 ITGB3 GDF2 GDF2 GHRL GHRL FGF2 FGF2 NGFR NGFR AIMP1 AIMP1 CAV1 CAV1 ITGA4 ITGA4 FLT1 FLT1 LEP LEP FUT1 FUT1 PIK3CD PIK3CD BMPR2 BMPR2 STAT3 STAT3 SPARC SPARC BMP4 BMP4 PRKD2 PRKD2 PDCD10 PDCD10 PROX1 PROX1 PGF PGF APOE APOE STAT5A STAT5A SYNJ2BP SYNJ2BP ENSCHIP00000025630 ENSCHIP00000025630 TGFBR1 TGFBR1 EGR3 EGR3 IL12A IL12A ALOX5 ALOX5 NR2F2 NR2F2 NRAS NRAS AKT1 AKT1 ENSCHIP00000027417 ENSCHIP00000027417 EGFL7 EGFL7 CCL26 CCL26 CCL2 CCL2 APLNR APLNR KRIT1 KRIT1 VEGFC VEGFC LOC102175359 LOC102175359 PRKCA PRKCA APOH APOH APELA APELA ENSCHIP00000029391 ENSCHIP00000029391 THBS4 THBS4 VEGFB VEGFB AKT3 AKT3 PDGFB PDGFB SIRT6 SIRT6 ALDH1A2 ALDH1A2 ENSCHIP00000031987 ENSCHIP00000031987 HTR2B HTR2B ENSCHIP00000032330 ENSCHIP00000032330 BMP6 BMP6 SULF1 SULF1 ACVRL1 ACVRL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNMDTenomodulin. (318 aa)
MMRN2Multimerin 2. (937 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
LOC102185958tRNA-binding domain-containing protein. (311 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1390 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (109 aa)
PROK1Prokineticin 1. (105 aa)
PDCD6Uncharacterized protein. (185 aa)
LOC102188312tRNA-binding domain-containing protein. (320 aa)
FGFBP1Fibroblast growth factor binding protein 1. (234 aa)
LOC102183240ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (547 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (214 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (623 aa)
STAT1Signal transducer and activator of transcription. (834 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
RNASE4Ribonuclease A family member 4; Belongs to the pancreatic ribonuclease family. (163 aa)
SCG2Secretogranin II. (635 aa)
CCL24C-C motif chemokine ligand 24. (116 aa)
NF1Neurofibromin 1. (2848 aa)
ECM1Extracellular matrix protein 1. (524 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (732 aa)
FGFR1Fibroblast growth factor receptor. (860 aa)
CDH13Cadherin 13. (663 aa)
ATOH8Atonal bHLH transcription factor 8. (315 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
ENSCHIP00000008714Uncharacterized protein. (170 aa)
CNMDChondromodulin. (335 aa)
VASH2Vasohibin 2. (355 aa)
PLXNB3Plexin B3. (1912 aa)
TBC1D31TBC1 domain family member 31. (1062 aa)
PPP1R16BProtein phosphatase 1 regulatory subunit 16B. (568 aa)
AGGF1Uncharacterized protein. (714 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
SP1Uncharacterized protein. (786 aa)
BMP2TGF_BETA_2 domain-containing protein. (381 aa)
CCL11C-C motif chemokine. (97 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
PDCL3Phosducin like 3. (241 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1139 aa)
JCADJunctional cadherin 5 associated. (1301 aa)
ADAM17ADAM metallopeptidase domain 17. (829 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1365 aa)
ENSCHIP00000011995Uncharacterized protein. (126 aa)
FUT2L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (339 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (560 aa)
VASH1Vasohibin 1. (363 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1495 aa)
DBHDopamine beta-hydroxylase. (616 aa)
VIPVasoactive intestinal peptide. (170 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (701 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
EMC10ER membrane protein complex subunit 10. (262 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
MEF2CMADS-box domain-containing protein. (441 aa)
HMOX1Heme oxygenase 1. (288 aa)
MYDGFMyeloid derived growth factor. (174 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (331 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (353 aa)
XDHFAD-binding PCMH-type domain-containing protein. (1331 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
THBS1Thrombospondin 1. (1218 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (786 aa)
GDF2Growth differentiation factor 2. (430 aa)
GHRLAppetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity). (133 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
NGFRNerve growth factor receptor. (427 aa)
AIMP1tRNA-binding domain-containing protein. (352 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (348 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SPARCOsteonectin. (303 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
PDCD10Uncharacterized protein. (212 aa)
PROX1Prospero homeobox 1. (734 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (140 aa)
APOEApolipoprotein E. (326 aa)
STAT5ASignal transducer and activator of transcription. (810 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
ENSCHIP00000025630tRNA-binding domain-containing protein. (304 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
EGR3Early growth response 3. (387 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (238 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
NR2F2Nuclear receptor subfamily 2 group F member 2. (419 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
ENSCHIP00000027417Uncharacterized protein. (185 aa)
EGFL7EGF like domain multiple 7. (319 aa)
CCL26C-C motif chemokine. (94 aa)
CCL2C-C motif chemokine. (98 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
KRIT1Uncharacterized protein. (736 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
LOC102175359PDZ domain-containing protein. (136 aa)
PRKCAUncharacterized protein. (605 aa)
APOHApolipoprotein H. (355 aa)
APELAUncharacterized protein. (54 aa)
ENSCHIP00000029391Uncharacterized protein. (179 aa)
THBS4Thrombospondin 4. (965 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (197 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
SIRT6Sirtuin 6. (335 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
ENSCHIP00000031987Non-specific serine/threonine protein kinase. (199 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
ENSCHIP00000032330Uncharacterized protein; Belongs to the ATPase alpha/beta chains family. (476 aa)
BMP6Bone morphogenetic protein 6. (496 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (868 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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