STRINGSTRING
PTGER4 PTGER4 FGL2 FGL2 CD19 CD19 UNC13D UNC13D RNF168 RNF168 IL21 IL21 SBNO2 SBNO2 LOC108635390 LOC108635390 ENSCHIP00000000047 ENSCHIP00000000047 VAMP7 VAMP7 LOC108634973 LOC108634973 ENPP3 ENPP3 LIG4 LIG4 SWAP70 SWAP70 LOC108636617 LOC108636617 LOC108635529 LOC108635529 LOC108636634 LOC108636634 LOC102180392 LOC102180392 LOC108633243 LOC108633243 RC3H1 RC3H1 LOC108636616 LOC108636616 LOC102179943 LOC102179943 LOC106502686 LOC106502686 S100A13 S100A13 KLRF2 KLRF2 EXOSC6 EXOSC6 LOC108636029 LOC108636029 PYCARD PYCARD LFNG LFNG SEMA4A SEMA4A NOTCH2 NOTCH2 DOCK2 DOCK2 KIT KIT ENSCHIP00000025560 ENSCHIP00000025560 DNASE1L3 DNASE1L3 TBX21 TBX21 IFI35 IFI35 MSH2 MSH2 ST3GAL1 ST3GAL1 ABL1 ABL1 CORO1A CORO1A SCNN1B SCNN1B NKG7 NKG7 DLL1 DLL1 STAT3 STAT3 POU2AF1 POU2AF1 BCR BCR MTOR MTOR SPI1 SPI1 LBP LBP ENSCHIP00000021158 ENSCHIP00000021158 LOC108635503 LOC108635503 ITFG2 ITFG2 LOC108635454 LOC108635454 RC3H2 RC3H2 LOC108635455 LOC108635455 LOC108633160 LOC108633160 ENSCHIP00000020058 ENSCHIP00000020058 DNASE1 DNASE1 RABGEF1 RABGEF1 STXBP2 STXBP2 TLR4 TLR4 EXOSC3 EXOSC3 TSC1 TSC1 PRKCE PRKCE ENSCHIP00000019035 ENSCHIP00000019035 CRACR2A CRACR2A NKX2-3 NKX2-3 MYD88 MYD88 PLCG2 PLCG2 SLC11A1 SLC11A1 HAVCR2 HAVCR2 IRF4 IRF4 LOC102181154 LOC102181154 IL12B IL12B ATAD5 ATAD5 ADORA2B ADORA2B IFNG IFNG IFNK IFNK BCL3 BCL3 ENSCHIP00000015409 ENSCHIP00000015409 LY9 LY9 SNAP23 SNAP23 RAB44 RAB44 ENSCHIP00000015031 ENSCHIP00000015031 CHGA CHGA DEF6 DEF6 FCER1G FCER1G LGALS1 LGALS1 ENSCHIP00000012937 ENSCHIP00000012937 FOXP3 FOXP3 HLX HLX CD74 CD74 KARS1 KARS1 MSH6 MSH6 CLEC4E CLEC4E ENSCHIP00000011351 ENSCHIP00000011351 ENSCHIP00000011123 ENSCHIP00000011123 LOC102181595 LOC102181595 EXO1 EXO1 S100A12 S100A12 GPR183 GPR183 LOC108636620 LOC108636620 RELB RELB ITGAL ITGAL AICDA AICDA IL6R IL6R CDH17 CDH17 LOC108636632 LOC108636632 IL6 IL6 SYK SYK CD180 CD180 STXBP3 STXBP3 TNFSF18 TNFSF18 LOC102189208 LOC102189208 GRP GRP ANXA3 ANXA3 TYROBP TYROBP CLEC4D CLEC4D NBN NBN LOC102180761 LOC102180761 GAPT GAPT ENTPD7 ENTPD7 VAMP2 VAMP2 LOC102181867 LOC102181867 LOC108636626 LOC108636626 RASGRP1 RASGRP1 PLCL2 PLCL2 LOC108636629 LOC108636629 LOC108636627 LOC108636627 LOC108635000 LOC108635000 IL18R1 IL18R1 LOC108636628 LOC108636628 FER1L5 FER1L5 ENSCHIP00000005465 ENSCHIP00000005465 SLAMF1 SLAMF1 LOC102174842 LOC102174842 BATF BATF IFNA IFNA MFNG MFNG LOC108636623 LOC108636623 LOC108634604 LOC108634604 LOC108636544 LOC108636544 TREX1 TREX1 UNG UNG SUCNR1 SUCNR1 TREM2 TREM2 IFNE IFNE LOC102186320 LOC102186320 LCP1 LCP1 DYSF DYSF CX3CR1 CX3CR1 RNF8 RNF8 KIAA1841 KIAA1841 PTK2B PTK2B F2RL1 F2RL1 BCL6 BCL6 MILR1 MILR1 ENSCHIP00000033427 ENSCHIP00000033427 TMEM98 TMEM98 ADA ADA IRF8 IRF8 CPLX2 CPLX2 ENSCHIP00000031771 ENSCHIP00000031771 PTGDR PTGDR RORA RORA STAT6 STAT6 ERCC1 ERCC1 ENSCHIP00000031025 ENSCHIP00000031025 CCR6 CCR6 NMI NMI LEF1 LEF1 PSEN1 PSEN1 ENSCHIP00000030196 ENSCHIP00000030196 GATA3 GATA3 TP53 TP53 DOCK11 DOCK11 SLAMF6 SLAMF6 EOMES EOMES IL2 IL2 PLA2G3 PLA2G3 LOC102179668 LOC102179668
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (513 aa)
FGL2Fibrinogen like 2. (441 aa)
CD19CD19 molecule. (561 aa)
UNC13DUnc-13 homolog D. (1086 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (157 aa)
SBNO2Strawberry notch homolog 2. (1377 aa)
LOC108635390Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (574 aa)
ENSCHIP00000000047RING-type domain-containing protein. (101 aa)
VAMP7Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (220 aa)
LOC108634973Uncharacterized protein. (195 aa)
ENPP3Ectonucleotide pyrophosphatase/phosphodiesterase 3. (874 aa)
LIG4DNA ligase. (911 aa)
SWAP70Switching B cell complex subunit SWAP70. (585 aa)
LOC108636617Uncharacterized protein. (195 aa)
LOC108635529Uncharacterized protein. (189 aa)
LOC108636634Uncharacterized protein. (186 aa)
LOC102180392Uncharacterized protein. (195 aa)
LOC108633243Uncharacterized protein. (186 aa)
RC3H1Ring finger and CCCH-type domains 1. (1123 aa)
LOC108636616Uncharacterized protein. (195 aa)
LOC102179943Uncharacterized protein. (189 aa)
LOC106502686Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (191 aa)
S100A13S100 calcium binding protein A13; Belongs to the S-100 family. (98 aa)
KLRF2Killer cell lectin like receptor F2. (199 aa)
EXOSC6Exosome component 6. (272 aa)
LOC108636029Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
PYCARDPYD and CARD domain containing. (196 aa)
LFNGBeta-1,3-N-acetylglucosaminyltransferase. (380 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (762 aa)
NOTCH2Notch receptor 2. (2471 aa)
DOCK2DHR-1 domain-containing protein; Belongs to the DOCK family. (846 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (974 aa)
ENSCHIP00000025560Ig-like domain-containing protein. (271 aa)
DNASE1L3Deoxyribonuclease; Belongs to the DNase I family. (305 aa)
TBX21T-box transcription factor 21. (533 aa)
IFI35Interferon induced protein 35. (263 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (946 aa)
ST3GAL1ST3 beta-galactoside alpha-2,3-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (339 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
SCNN1BSodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (774 aa)
NKG7Natural killer cell granule protein 7. (165 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
POU2AF1POU class 2 homeobox associating factor 1. (263 aa)
BCRBCR activator of RhoGEF and GTPase. (1130 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
SPI1Spi-1 proto-oncogene. (270 aa)
LBPLipopolysaccharide binding protein. (481 aa)
ENSCHIP00000021158Uncharacterized protein. (182 aa)
LOC108635503Uncharacterized protein. (195 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (444 aa)
LOC108635454Uncharacterized protein. (195 aa)
RC3H2Ring finger and CCCH-type domains 2. (1189 aa)
LOC108635455Uncharacterized protein. (195 aa)
LOC108633160Uncharacterized protein. (189 aa)
ENSCHIP00000020058Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (559 aa)
DNASE1Deoxyribonuclease; Belongs to the DNase I family. (282 aa)
RABGEF1Uncharacterized protein. (500 aa)
STXBP2Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (588 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
EXOSC3Exosome component 3. (275 aa)
TSC1Uncharacterized protein. (1158 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (608 aa)
ENSCHIP00000019035Uncharacterized protein. (191 aa)
CRACR2ACalcium release activated channel regulator 2A. (723 aa)
NKX2-3NK2 homeobox 3. (367 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
SLC11A1Uncharacterized protein. (571 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
IRF4Interferon regulatory factor 4. (450 aa)
LOC102181154C-C motif chemokine. (93 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (331 aa)
ATAD5ATPase family AAA domain containing 5. (1894 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
IFNKInterferon kappa. (205 aa)
BCL3BCL3 transcription coactivator. (454 aa)
ENSCHIP00000015409Lysine--tRNA ligase. (599 aa)
LY9Ig-like domain-containing protein. (511 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (208 aa)
RAB44RAB44, member RAS oncogene family. (976 aa)
ENSCHIP00000015031Uncharacterized protein. (173 aa)
CHGAChromogranin A. (534 aa)
DEF6DEF6 guanine nucleotide exchange factor. (632 aa)
FCER1GFc fragment of IgE receptor Ig. (76 aa)
LGALS1Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Has hemaglutinating activity towards human erythrocytes. (136 aa)
ENSCHIP00000012937Uncharacterized protein. (188 aa)
FOXP3Forkhead box P3. (463 aa)
HLXH2.0 like homeobox. (488 aa)
CD74CD74 molecule. (261 aa)
KARS1Lysine--tRNA ligase. (623 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
CLEC4EC-type lectin domain family 4 member E. (212 aa)
ENSCHIP00000011351Uncharacterized protein. (171 aa)
ENSCHIP00000011123Uncharacterized protein. (190 aa)
LOC102181595Uncharacterized protein. (186 aa)
EXO1Exonuclease 1. (835 aa)
S100A12Protein S100; Belongs to the S-100 family. (92 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (356 aa)
LOC108636620Uncharacterized protein. (195 aa)
RELBRELB proto-oncogene, NF-kB subunit. (645 aa)
ITGALVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1178 aa)
AICDAActivation induced cytidine deaminase. (199 aa)
IL6RInterleukin 6 receptor. (441 aa)
CDH17Cadherin 17. (832 aa)
LOC108636632Uncharacterized protein. (186 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
CD180CD180 molecule. (661 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (593 aa)
TNFSF18TNF superfamily member 18. (194 aa)
LOC102189208Uncharacterized protein. (168 aa)
GRPGastrin releasing peptide. (159 aa)
ANXA3Annexin. (323 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (111 aa)
CLEC4DC-type lectin domain family 4 member D. (212 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
LOC102180761Uncharacterized protein. (189 aa)
GAPTGRB2 binding adaptor protein, transmembrane. (158 aa)
ENTPD7Ectonucleoside triphosphate diphosphohydrolase 7; Belongs to the GDA1/CD39 NTPase family. (604 aa)
VAMP2V-SNARE coiled-coil homology domain-containing protein. (116 aa)
LOC102181867Uncharacterized protein. (186 aa)
LOC108636626Uncharacterized protein. (195 aa)
RASGRP1RAS guanyl releasing protein 1. (773 aa)
PLCL2Phosphoinositide phospholipase C. (1118 aa)
LOC108636629Uncharacterized protein. (186 aa)
LOC108636627Uncharacterized protein. (189 aa)
LOC108635000Uncharacterized protein. (195 aa)
IL18R1Interleukin 18 receptor 1. (538 aa)
LOC108636628Uncharacterized protein. (195 aa)
FER1L5Fer-1 like family member 5. (1921 aa)
ENSCHIP00000005465Uncharacterized protein. (168 aa)
SLAMF1Ig-like domain-containing protein. (338 aa)
LOC102174842Uncharacterized protein. (189 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
IFNAUncharacterized protein. (189 aa)
MFNGBeta-1,3-N-acetylglucosaminyltransferase. (320 aa)
LOC108636623Uncharacterized protein. (195 aa)
LOC108634604Uncharacterized protein. (195 aa)
LOC108636544Uncharacterized protein. (186 aa)
TREX1Three prime repair exonuclease 1. (315 aa)
UNGUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (311 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (316 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
IFNEInterferon epsilon. (193 aa)
LOC102186320Uncharacterized protein. (479 aa)
LCP1Lymphocyte cytosolic protein 1. (627 aa)
DYSFDysferlin. (2039 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (504 aa)
KIAA1841KIAA1841. (704 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
BCL6BCL6 transcription repressor. (706 aa)
MILR1Ig-like domain-containing protein. (225 aa)
ENSCHIP00000033427Uncharacterized protein. (262 aa)
TMEM98Transmembrane protein 98. (226 aa)
ADAAdenosine deaminase. (400 aa)
IRF8Interferon regulatory factor 8. (426 aa)
CPLX2Complexin 2. (134 aa)
ENSCHIP00000031771C2 domain-containing protein. (204 aa)
PTGDRProstaglandin D2 receptor. (361 aa)
RORAUncharacterized protein. (527 aa)
STAT6Signal transducer and activator of transcription. (841 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (294 aa)
ENSCHIP00000031025Uncharacterized protein. (171 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
NMIN-myc and STAT interactor. (309 aa)
LEF1HMG box domain-containing protein. (430 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (475 aa)
ENSCHIP00000030196Uncharacterized protein. (144 aa)
GATA3GATA binding protein 3. (467 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
DOCK11Dedicator of cytokinesis 11; Belongs to the DOCK family. (2087 aa)
SLAMF6Ig-like domain-containing protein. (351 aa)
EOMESEomesodermin. (701 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
PLA2G3Phospholipase A2 group III. (509 aa)
LOC102179668Uncharacterized protein. (191 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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