STRINGSTRING
ENSCHIP00000013896 ENSCHIP00000013896 ZMIZ1 ZMIZ1 ADPRHL1 ADPRHL1 NODAL NODAL SYNPO2L SYNPO2L BMPR1A BMPR1A ENSCHIP00000000870 ENSCHIP00000000870 MIB1 MIB1 HAND1 HAND1 POU4F1 POU4F1 TCAP TCAP GJA1 GJA1 JUN JUN ACTC1 ACTC1 EFNA1 EFNA1 ADAM15 ADAM15 CCDC40 CCDC40 CRKL CRKL LOC102170800 LOC102170800 ADAMTS1 ADAMTS1 RTN4 RTN4 DNAAF1 DNAAF1 SLIT3 SLIT3 MESP1 MESP1 FLRT2 FLRT2 TREX1 TREX1 S1PR1 S1PR1 DHRS3 DHRS3 TNNI1 TNNI1 WNT16 WNT16 GAA GAA MEF2C MEF2C WNT3A WNT3A WNT5A WNT5A SHOX2 SHOX2 NRP2 NRP2 EGLN1 EGLN1 FAT4 FAT4 NPHP3 NPHP3 ZFPM2 ZFPM2 HIF1A HIF1A TGFBR3 TGFBR3 ARL13B ARL13B FOXH1 FOXH1 DLL4 DLL4 CCN1 CCN1 GSK3A GSK3A RYR2 RYR2 ACVRL1 ACVRL1 HEY2 HEY2 ENG ENG RBM15 RBM15 HTR2B HTR2B KDM6A KDM6A NPY5R NPY5R TEAD2 TEAD2 BMP10 BMP10 ALDH1A2 ALDH1A2 PPP1R13L PPP1R13L DVL2 DVL2 CCDC39 CCDC39 ASXL1 ASXL1 AHI1 AHI1 PSEN1 PSEN1 FHL2 FHL2 CPE CPE GATA3 GATA3 TP53 TP53 SMARCD3 SMARCD3 MYL10 MYL10 SIX1 SIX1 PARVA PARVA MICAL2 MICAL2 ALPK2 ALPK2 ADPRH ADPRH MED1 MED1 TBX5 TBX5 APLNR APLNR LBX1 LBX1 MKS1 MKS1 SHH SHH SMO SMO SFRP2 SFRP2 TGFB2 TGFB2 NOTCH2 NOTCH2 ADGRG6 ADGRG6 ISL1 ISL1 TGFBR1 TGFBR1 CLUAP1 CLUAP1 IFT52 IFT52 MYBPC3 MYBPC3 EYA1 EYA1 SUFU SUFU CERT1 CERT1 WNT11 WNT11 ZIC3 ZIC3 SOX9 SOX9 PROX1 PROX1 MYH7 MYH7 FOLR1 FOLR1 NOTCH1 NOTCH1 BMP4 BMP4 CCDC103 CCDC103 JAG1 JAG1 SOX17 SOX17 DLL1 DLL1 TNNT2 TNNT2 AXIN2 AXIN2 PKD2 PKD2 BMPR2 BMPR2 MTOR MTOR EDNRA EDNRA CCM2L CCM2L SMAD7 SMAD7 TNNC1 TNNC1 SMAD4 SMAD4 LRP2 LRP2 SOS1 SOS1 FOXF1 FOXF1 GATA6 GATA6 IHH IHH MESP2 MESP2 ANKRD1 ANKRD1 SEC24B SEC24B IFT57 IFT57 ELN ELN HES1 HES1 GRHL2 GRHL2 LEMD2 LEMD2 ILK ILK NKX2-5 NKX2-5 MYH6 MYH6 SEMA3C SEMA3C MYLK2 MYLK2 YAP1 YAP1 ENSCHIP00000016973 ENSCHIP00000016973 FGF8 FGF8 ENSCHIP00000016631 ENSCHIP00000016631 PLXND1 PLXND1 EXT1 EXT1 NOG NOG NSD2 NSD2 GATA4 GATA4 COL2A1 COL2A1 BMP7 BMP7 CAV3 CAV3 NPY2R NPY2R ZFPM1 ZFPM1 ASB2 ASB2 C2CD3 C2CD3 GJA5 GJA5 ARID2 ARID2 WNT2 WNT2 TBXT TBXT TBX20 TBX20 NIPBL NIPBL FLNA FLNA HAS2 HAS2 ATF2 ATF2 DNAH11 DNAH11 TGFBR2 TGFBR2 CHD7 CHD7 EMP2 EMP2 EDN1 EDN1 ENSCHIP00000008875 ENSCHIP00000008875 TGFB1 TGFB1 SRF SRF NPY1R NPY1R TBX3 TBX3 HAND2 HAND2 SMAD6 SMAD6 TMEM100 TMEM100 SAV1 SAV1 BMP2 BMP2 DCHS1 DCHS1 TBX6 TBX6 SOX4 SOX4 HEYL HEYL DSP DSP SMAD3 SMAD3 PTCH1 PTCH1 MYL3 MYL3 TBX19 TBX19 CDC42 CDC42 TEK TEK MSX1 MSX1 INSR INSR SNAI1 SNAI1 ZMPSTE24 ZMPSTE24 TBX2 TBX2 GATA5 GATA5 PKP2 PKP2 TAB1 TAB1 MEGF8 MEGF8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCHIP00000013896Uncharacterized protein. (179 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1072 aa)
ADPRHL1ADP-ribosylhydrolase like 1. (354 aa)
NODALNodal growth differentiation factor. (346 aa)
SYNPO2LSynaptopodin 2 like. (974 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ENSCHIP00000000870Ig-like domain-containing protein. (132 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1006 aa)
HAND1Heart and neural crest derivatives expressed 1. (219 aa)
POU4F1POU domain protein. (421 aa)
TCAPUncharacterized protein. (167 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
ACTC1Actin alpha cardiac muscle 1. (377 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
ADAM15ADAM metallopeptidase domain 15. (866 aa)
CCDC40Coiled-coil domain containing 40. (937 aa)
CRKLCRK like proto-oncogene, adaptor protein. (302 aa)
LOC102170800Uncharacterized protein. (537 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (971 aa)
RTN4Reticulon. (1194 aa)
DNAAF1Dynein assembly factor 1, axonemal. (643 aa)
SLIT3Slit guidance ligand 3. (1320 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (256 aa)
FLRT2Fibronectin leucine rich transmembrane protein 2. (660 aa)
TREX1Three prime repair exonuclease 1. (315 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
TNNI1Troponin I1, slow skeletal type. (187 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
GAAGlucosidase alpha, acid; Belongs to the glycosyl hydrolase 31 family. (935 aa)
MEF2CMADS-box domain-containing protein. (441 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
SHOX2Short stature homeobox 2. (319 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
EGLN1Uncharacterized protein. (422 aa)
FAT4FAT atypical cadherin 4. (4982 aa)
NPHP3TPR_REGION domain-containing protein. (1325 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1022 aa)
HIF1AUncharacterized protein. (823 aa)
TGFBR3Transforming growth factor beta receptor 3. (859 aa)
ARL13BADP ribosylation factor like GTPase 13B. (429 aa)
FOXH1Forkhead box H1. (360 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (701 aa)
CCN1Cellular communication network factor 1. (382 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
RYR2Ryanodine receptor 2. (4943 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
ENGEndoglin. (649 aa)
RBM15RNA binding motif protein 15. (962 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
KDM6ALysine demethylase 6A. (1386 aa)
NPY5RNeuropeptide Y receptor Y5. (454 aa)
TEAD2TEA domain transcription factor 2. (448 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
PPP1R13LProtein phosphatase 1 regulatory subunit 13 like. (823 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
CCDC39Coiled-coil domain containing 39. (931 aa)
ASXL1ASXL transcriptional regulator 1. (1536 aa)
AHI1Abelson helper integration site 1. (1194 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (475 aa)
FHL2Four and a half LIM domains 2. (279 aa)
CPECarboxypeptidase E. (474 aa)
GATA3GATA binding protein 3. (467 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
MYL10Myosin light chain 10. (222 aa)
SIX1SIX homeobox 1. (284 aa)
PARVAParvin alpha. (412 aa)
MICAL2Microtubule associated monooxygenase, calponin and LIM domain containing 2. (1122 aa)
ALPK2Alpha kinase 2. (2148 aa)
ADPRHADP-ribosylarginine hydrolase. (354 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1577 aa)
TBX5T-box transcription factor 5. (594 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
LBX1Ladybird homeobox 1. (281 aa)
MKS1MKS transition zone complex subunit 1. (645 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NOTCH2Notch receptor 2. (2471 aa)
ADGRG6Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family. (1250 aa)
ISL1ISL LIM homeobox 1. (349 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
CLUAP1Clusterin associated protein 1. (438 aa)
IFT52Intraflagellar transport 52. (448 aa)
MYBPC3Myosin binding protein C, cardiac. (1303 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
CERT1Ceramide transporter 1. (759 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ZIC3Zic family member 3. (465 aa)
SOX9SRY-box transcription factor 9. (525 aa)
PROX1Prospero homeobox 1. (734 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1955 aa)
FOLR1Folate_rec domain-containing protein. (251 aa)
NOTCH1Notch receptor 1. (2508 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CCDC103Coiled-coil domain containing 103. (235 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
SOX17SRY-box transcription factor 17. (410 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
TNNT2Troponin T2, cardiac type. (267 aa)
AXIN2Axin 2. (844 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (978 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
CCM2LCCM2 like scaffold protein. (568 aa)
SMAD7Mothers against decapentaplegic homolog. (427 aa)
TNNC1Uncharacterized protein. (154 aa)
SMAD4Mothers against decapentaplegic homolog. (513 aa)
LRP2LDL receptor related protein 2. (4649 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
FOXF1Forkhead box F1. (391 aa)
GATA6GATA binding protein 6. (592 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
MESP2Mesoderm posterior bHLH transcription factor 2. (366 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1261 aa)
IFT57Intraflagellar transport 57. (429 aa)
ELNUncharacterized protein. (504 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
GRHL2Grainyhead like transcription factor 2. (622 aa)
LEMD2LEM domain containing 2. (495 aa)
ILKIntegrin linked kinase. (452 aa)
NKX2-5NK2 homeobox 5. (323 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1943 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (765 aa)
MYLK2Myosin light chain kinase 2. (632 aa)
YAP1Yes associated protein 1. (503 aa)
ENSCHIP00000016973Uncharacterized protein. (864 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
ENSCHIP00000016631HARE-HTH domain-containing protein. (59 aa)
PLXND1Plexin D1. (1926 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (446 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
GATA4GATA binding protein 4. (442 aa)
COL2A1Collagen type II alpha 1 chain. (1259 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
NPY2RNeuropeptide Y receptor Y2; Belongs to the G-protein coupled receptor 1 family. (384 aa)
ZFPM1Zinc finger protein, FOG family member 1. (988 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (633 aa)
C2CD3C2 domain containing 3 centriole elongation regulator. (2333 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (359 aa)
ARID2AT-rich interaction domain 2. (1835 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
TBXTT-box transcription factor T. (435 aa)
TBX20T-box transcription factor 20. (449 aa)
NIPBLNipped-B protein. (2804 aa)
FLNAFilamin A. (2647 aa)
HAS2Uncharacterized protein. (552 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
DNAH11Dynein axonemal heavy chain 11. (4508 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2993 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
EDN1Endothelin 1. (202 aa)
ENSCHIP00000008875BMERB domain-containing protein. (705 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SRFSerum response factor. (509 aa)
NPY1RNeuropeptide Y receptor Y1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
TBX3T-box transcription factor 3. (749 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
SMAD6Mothers against decapentaplegic homolog. (497 aa)
TMEM100Transmembrane protein 100. (134 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
BMP2TGF_BETA_2 domain-containing protein. (381 aa)
DCHS1Dachsous cadherin-related 1. (3258 aa)
TBX6T-box transcription factor 6. (437 aa)
SOX4SRY-box transcription factor 4. (504 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
DSPDesmoplakin. (2892 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PTCH1Patched 1. (1453 aa)
MYL3Myosin light chain 3. (194 aa)
TBX19T-box transcription factor 19. (446 aa)
CDC42Uncharacterized protein. (191 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
MSX1Msh homeobox 1. (303 aa)
INSRTyrosine-protein kinase receptor. (1365 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
TBX2T-box transcription factor 2. (771 aa)
GATA5GATA binding protein 5. (403 aa)
PKP2Plakophilin 2. (851 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
MEGF8Multiple EGF like domains 8. (2836 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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