STRINGSTRING
TBX20 TBX20 DNAH11 DNAH11 TGFBR2 TGFBR2 CCN1 CCN1 GSK3A GSK3A RYR2 RYR2 HEY2 HEY2 ENG ENG RBM15 RBM15 NPY5R NPY5R BMP10 BMP10 PPP1R13L PPP1R13L FHL2 FHL2 CPE CPE GATA3 GATA3 TP53 TP53 SMARCD3 SMARCD3 MYL10 MYL10 PARVA PARVA ADPRH ADPRH MED1 MED1 TBX5 TBX5 APLNR APLNR MKS1 MKS1 SMO SMO HES1 HES1 GRHL2 GRHL2 NKX2-5 NKX2-5 MYH6 MYH6 SEMA3C SEMA3C FGF8 FGF8 TNNI1 TNNI1 MEF2C MEF2C WNT5A WNT5A SHOX2 SHOX2 NRP2 NRP2 EGLN1 EGLN1 ZFPM2 ZFPM2 HIF1A HIF1A FOXH1 FOXH1 DLL4 DLL4 ENSCHIP00000013896 ENSCHIP00000013896 PKP2 PKP2 TBX2 TBX2 TEK TEK MYL3 MYL3 DSP DSP HEYL HEYL SOX4 SOX4 BMP2 BMP2 SAV1 SAV1 SMAD6 SMAD6 HAND2 HAND2 TBX3 TBX3 SRF SRF TGFB1 TGFB1 BMPR2 BMPR2 EDNRA EDNRA SMAD7 SMAD7 TNNC1 TNNC1 SMAD4 SMAD4 LRP2 LRP2 SOS1 SOS1 FOXF1 FOXF1 GATA6 GATA6 SFRP2 SFRP2 NOTCH2 NOTCH2 ADGRG6 ADGRG6 ISL1 ISL1 TGFBR1 TGFBR1 MYBPC3 MYBPC3 WNT11 WNT11 PROX1 PROX1 MYH7 MYH7 NOTCH1 NOTCH1 BMP4 BMP4 JAG1 JAG1 TNNT2 TNNT2 CHD7 CHD7 ADPRHL1 ADPRHL1 BMPR1A BMPR1A ENSCHIP00000000870 ENSCHIP00000000870 HAND1 HAND1 POU4F1 POU4F1 ADAMTS1 ADAMTS1 SLIT3 SLIT3 MESP1 MESP1 DHRS3 DHRS3 NOG NOG NSD2 NSD2 GATA4 GATA4 BMP7 BMP7 CAV3 CAV3 NPY2R NPY2R ZFPM1 ZFPM1 WNT2 WNT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBX20T-box transcription factor 20. (449 aa)
DNAH11Dynein axonemal heavy chain 11. (4508 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
CCN1Cellular communication network factor 1. (382 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
RYR2Ryanodine receptor 2. (4943 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
ENGEndoglin. (649 aa)
RBM15RNA binding motif protein 15. (962 aa)
NPY5RNeuropeptide Y receptor Y5. (454 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
PPP1R13LProtein phosphatase 1 regulatory subunit 13 like. (823 aa)
FHL2Four and a half LIM domains 2. (279 aa)
CPECarboxypeptidase E. (474 aa)
GATA3GATA binding protein 3. (467 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
MYL10Myosin light chain 10. (222 aa)
PARVAParvin alpha. (412 aa)
ADPRHADP-ribosylarginine hydrolase. (354 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1577 aa)
TBX5T-box transcription factor 5. (594 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
MKS1MKS transition zone complex subunit 1. (645 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
GRHL2Grainyhead like transcription factor 2. (622 aa)
NKX2-5NK2 homeobox 5. (323 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1943 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (765 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
TNNI1Troponin I1, slow skeletal type. (187 aa)
MEF2CMADS-box domain-containing protein. (441 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
SHOX2Short stature homeobox 2. (319 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
EGLN1Uncharacterized protein. (422 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1022 aa)
HIF1AUncharacterized protein. (823 aa)
FOXH1Forkhead box H1. (360 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (701 aa)
ENSCHIP00000013896Uncharacterized protein. (179 aa)
PKP2Plakophilin 2. (851 aa)
TBX2T-box transcription factor 2. (771 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
MYL3Myosin light chain 3. (194 aa)
DSPDesmoplakin. (2892 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
SOX4SRY-box transcription factor 4. (504 aa)
BMP2TGF_BETA_2 domain-containing protein. (381 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
SMAD6Mothers against decapentaplegic homolog. (497 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
TBX3T-box transcription factor 3. (749 aa)
SRFSerum response factor. (509 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SMAD7Mothers against decapentaplegic homolog. (427 aa)
TNNC1Uncharacterized protein. (154 aa)
SMAD4Mothers against decapentaplegic homolog. (513 aa)
LRP2LDL receptor related protein 2. (4649 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
FOXF1Forkhead box F1. (391 aa)
GATA6GATA binding protein 6. (592 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
NOTCH2Notch receptor 2. (2471 aa)
ADGRG6Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family. (1250 aa)
ISL1ISL LIM homeobox 1. (349 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
MYBPC3Myosin binding protein C, cardiac. (1303 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PROX1Prospero homeobox 1. (734 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1955 aa)
NOTCH1Notch receptor 1. (2508 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
TNNT2Troponin T2, cardiac type. (267 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2993 aa)
ADPRHL1ADP-ribosylhydrolase like 1. (354 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ENSCHIP00000000870Ig-like domain-containing protein. (132 aa)
HAND1Heart and neural crest derivatives expressed 1. (219 aa)
POU4F1POU domain protein. (421 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (971 aa)
SLIT3Slit guidance ligand 3. (1320 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (256 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
GATA4GATA binding protein 4. (442 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
NPY2RNeuropeptide Y receptor Y2; Belongs to the G-protein coupled receptor 1 family. (384 aa)
ZFPM1Zinc finger protein, FOG family member 1. (988 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.