(14 nodes) Type B pancreatic cell development network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BMP6	Bone morphogenetic protein 6. (496 aa)
	GDF11	Growth differentiation factor 11. (406 aa)
	BHLHA15	Basic helix-loop-helix family member a15. (186 aa)
	BMP5	Bone morphogenetic protein 5. (454 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	SIDT2	SID1 transmembrane family member 2. (835 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (557 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	HNF4A	Hepatocyte nuclear factor 4 alpha. (486 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
	NKX2-2	NK2 homeobox 2. (273 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	BMP5	ENSCHIP00000023678	ENSCHIP00000006646	Bone morphogenetic protein 4.	Bone morphogenetic protein 5.	0.795
BMP4	BMP6	ENSCHIP00000023678	ENSCHIP00000032648	Bone morphogenetic protein 4.	Bone morphogenetic protein 6.	0.967
BMP4	SMO	ENSCHIP00000023678	ENSCHIP00000027079	Bone morphogenetic protein 4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.639
BMP4	WNT5A	ENSCHIP00000023678	ENSCHIP00000015533	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.731
BMP5	BMP4	ENSCHIP00000006646	ENSCHIP00000023678	Bone morphogenetic protein 5.	Bone morphogenetic protein 4.	0.795
BMP6	BMP4	ENSCHIP00000032648	ENSCHIP00000023678	Bone morphogenetic protein 6.	Bone morphogenetic protein 4.	0.967
BMP6	WNT5A	ENSCHIP00000032648	ENSCHIP00000015533	Bone morphogenetic protein 6.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.437
CDH2	CDK6	ENSCHIP00000019820	ENSCHIP00000008415	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.506
CDH2	WNT5A	ENSCHIP00000019820	ENSCHIP00000015533	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.470
CDK6	CDH2	ENSCHIP00000008415	ENSCHIP00000019820	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	0.506
SMO	BMP4	ENSCHIP00000027079	ENSCHIP00000023678	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	Bone morphogenetic protein 4.	0.639
SMO	WNT5A	ENSCHIP00000027079	ENSCHIP00000015533	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.525
WNT5A	BMP4	ENSCHIP00000015533	ENSCHIP00000023678	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Bone morphogenetic protein 4.	0.731
WNT5A	BMP6	ENSCHIP00000015533	ENSCHIP00000032648	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Bone morphogenetic protein 6.	0.437
WNT5A	CDH2	ENSCHIP00000015533	ENSCHIP00000019820	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	0.470
WNT5A	SMO	ENSCHIP00000015533	ENSCHIP00000027079	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.525