39 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DNASE1L1	Deoxyribonuclease; Belongs to the DNase I family. (316 aa)
	ENSCHIP00000031547	HTH_48 domain-containing protein. (342 aa)
	ENSCHIP00000031435	Uncharacterized protein. (77 aa)
	ZRANB3	Zinc finger RANBP2-type containing 3. (1070 aa)
	ERCC1	ERCC excision repair 1, endonuclease non-catalytic subunit. (294 aa)
	MUS81	MUS81 structure-specific endonuclease subunit. (552 aa)
	ERCC4	ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
	DNASE1L3	Deoxyribonuclease; Belongs to the DNase I family. (305 aa)
	MRE11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (724 aa)
	ENSCHIP00000024183	Uncharacterized protein. (207 aa)
	ENDOV	Endonuclease V. (307 aa)
	FAN1	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1022 aa)
	BIVM	Uncharacterized protein. (502 aa)
	SLX1A	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (267 aa)
	ENDOG	Endonuclease. (299 aa)
	XRCC1	X-ray repair cross complementing 1. (632 aa)
	ANKLE1	Ankyrin repeat and LEM domain containing 1. (487 aa)
	DNA2	DNA replication helicase/nuclease 2. (1062 aa)
	DNASE1	Deoxyribonuclease; Belongs to the DNase I family. (282 aa)
	DNASE2B	Deoxyribonuclease 2 beta. (359 aa)
	DNASE2	Deoxyribonuclease 2, lysosomal. (373 aa)
	ENSCHIP00000015226	KH type-2 domain-containing protein. (204 aa)
	DICER1	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1922 aa)
	DCLRE1C	DNA cross-link repair 1C. (710 aa)
	RAD51C	RAD51 paralog C. (371 aa)
	APLF	Aprataxin and PNKP like factor. (480 aa)
	ENSCHIP00000012960	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (287 aa)
	ERCC5	ERCC excision repair 5, endonuclease. (1190 aa)
	GEN1	GEN1 Holliday junction 5' flap endonuclease. (931 aa)
	EXOG	Exo/endonuclease G. (368 aa)
	RBBP8	RB binding protein 8, endonuclease. (889 aa)
	EXO1	Exonuclease 1. (835 aa)
	RPS3	Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	DFFB	DNA fragmentation factor subunit beta. (370 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	DNASE1L2	Deoxyribonuclease; Belongs to the DNase I family. (278 aa)
	APEX1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
	RAD50	Zinc-hook domain-containing protein. (1332 aa)
	LOC102177756	HTH_48 domain-containing protein. (337 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APEX1	BIVM	ENSCHIP00000003281	ENSCHIP00000023511	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Uncharacterized protein.	0.460
APEX1	ERCC1	ENSCHIP00000003281	ENSCHIP00000031141	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	ERCC excision repair 1, endonuclease non-catalytic subunit.	0.662
APEX1	ERCC4	ENSCHIP00000003281	ENSCHIP00000026065	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	ERCC excision repair 4, endonuclease catalytic subunit.	0.785
APEX1	ERCC5	ENSCHIP00000003281	ENSCHIP00000012626	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	ERCC excision repair 5, endonuclease.	0.596
APEX1	EXO1	ENSCHIP00000003281	ENSCHIP00000010493	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Exonuclease 1.	0.614
APEX1	FEN1	ENSCHIP00000003281	ENSCHIP00000005017	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.936
APEX1	GEN1	ENSCHIP00000003281	ENSCHIP00000011906	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	GEN1 Holliday junction 5' flap endonuclease.	0.460
APEX1	MRE11	ENSCHIP00000003281	ENSCHIP00000024516	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.417
APEX1	MUS81	ENSCHIP00000003281	ENSCHIP00000028466	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	MUS81 structure-specific endonuclease subunit.	0.542
APEX1	XRCC1	ENSCHIP00000003281	ENSCHIP00000022965	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	X-ray repair cross complementing 1.	0.759
APLF	ERCC4	ENSCHIP00000013911	ENSCHIP00000026065	Aprataxin and PNKP like factor.	ERCC excision repair 4, endonuclease catalytic subunit.	0.482
APLF	FAN1	ENSCHIP00000013911	ENSCHIP00000023592	Aprataxin and PNKP like factor.	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	0.467
APLF	XRCC1	ENSCHIP00000013911	ENSCHIP00000022965	Aprataxin and PNKP like factor.	X-ray repair cross complementing 1.	0.945
BIVM	APEX1	ENSCHIP00000023511	ENSCHIP00000003281	Uncharacterized protein.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.460
BIVM	DNA2	ENSCHIP00000023511	ENSCHIP00000020258	Uncharacterized protein.	DNA replication helicase/nuclease 2.	0.750
BIVM	ENSCHIP00000012960	ENSCHIP00000023511	ENSCHIP00000012960	Uncharacterized protein.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.460
BIVM	ERCC1	ENSCHIP00000023511	ENSCHIP00000031141	Uncharacterized protein.	ERCC excision repair 1, endonuclease non-catalytic subunit.	0.725
BIVM	ERCC4	ENSCHIP00000023511	ENSCHIP00000026065	Uncharacterized protein.	ERCC excision repair 4, endonuclease catalytic subunit.	0.809
BIVM	ERCC5	ENSCHIP00000023511	ENSCHIP00000012626	Uncharacterized protein.	ERCC excision repair 5, endonuclease.	0.814
BIVM	MRE11	ENSCHIP00000023511	ENSCHIP00000024516	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.789