STRINGSTRING
SMARCAL1 SMARCAL1 UHRF1 UHRF1 PRPF19 PRPF19 TIPIN TIPIN TEX264 TEX264 ENSCHIP00000002654 ENSCHIP00000002654 ENSCHIP00000003676 ENSCHIP00000003676 TREX1 TREX1 RAD18 RAD18 RFC2 RFC2 ZMIZ2 ZMIZ2 POLD2 POLD2 TP53BP1 TP53BP1 POLH POLH XPA XPA TIMELESS TIMELESS HMCES HMCES BCL6 BCL6 CHEK1 CHEK1 WDHD1 WDHD1 UBE2B UBE2B RFC5 RFC5 POLA1 POLA1 RTF2 RTF2 LOC108637664 LOC108637664 PRIMPOL PRIMPOL XRCC2 XRCC2 POLD3 POLD3 RPA3 RPA3 DNMT1 DNMT1 BCAS2 BCAS2 CDC5L CDC5L DMAP1 DMAP1 MCM10 MCM10 RADX RADX MRE11 MRE11 POLA2 POLA2 XRCC3 XRCC3 TONSL TONSL PCNA PCNA RAD51C RAD51C WRN WRN PIF1 PIF1 RAD51B RAD51B ENSCHIP00000012479 ENSCHIP00000012479 PLRG1 PLRG1 SMARCA5 SMARCA5 SMARCAD1 SMARCAD1 ENSCHIP00000010204 ENSCHIP00000010204 RFC3 RFC3 POLD4 POLD4 NBN NBN TP53 TP53 PRIM1 PRIM1 RFC4 RFC4 DONSON DONSON RFC1 RFC1 RAD51D RAD51D MMS22L MMS22L BAZ1B BAZ1B ETAA1 ETAA1 HELB HELB POLD1 POLD1 RPA2 RPA2 RPA1 RPA1 PRIM2 PRIM2 ZRANB3 ZRANB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (930 aa)
UHRF1Ubiquitin like with PHD and ring finger domains 1. (786 aa)
PRPF19Pre-mRNA processing factor 19. (504 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (289 aa)
TEX264Testis expressed 264, ER-phagy receptor. (314 aa)
ENSCHIP00000002654Uncharacterized protein. (121 aa)
ENSCHIP00000003676RECA_2 domain-containing protein. (278 aa)
TREX1Three prime repair exonuclease 1. (315 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (502 aa)
RFC2Replication factor C subunit 2. (352 aa)
ZMIZ2Zinc finger MIZ-type containing 2. (934 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
TP53BP1Tumor protein p53 binding protein 1. (1966 aa)
POLHDNA polymerase eta. (733 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
TIMELESSTimeless circadian regulator. (1206 aa)
HMCESAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (374 aa)
BCL6BCL6 transcription repressor. (706 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
WDHD1WD repeat and HMG-box DNA binding protein 1. (1124 aa)
UBE2BUbiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
RFC5Replication factor C subunit 5. (339 aa)
POLA1DNA polymerase. (1468 aa)
RTF2Replication termination factor 2. (341 aa)
LOC108637664Uncharacterized protein. (1041 aa)
PRIMPOLPrimase and DNA directed polymerase. (554 aa)
XRCC2X-ray repair cross complementing 2. (280 aa)
POLD3Uncharacterized protein. (464 aa)
RPA3Uncharacterized protein. (121 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1591 aa)
BCAS2Uncharacterized protein. (225 aa)
CDC5LCell division cycle 5 like. (802 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (468 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (900 aa)
RADXRPA1 related single stranded DNA binding protein, X-linked. (764 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (724 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (603 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (341 aa)
TONSLTonsoku like, DNA repair protein. (1371 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
RAD51CRAD51 paralog C. (371 aa)
WRNWRN RecQ like helicase. (1405 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (649 aa)
RAD51BRAD51 paralog B. (270 aa)
ENSCHIP00000012479Uncharacterized protein. (215 aa)
PLRG1Pleiotropic regulator 1. (514 aa)
SMARCA5Uncharacterized protein. (1052 aa)
SMARCAD1Uncharacterized protein. (1028 aa)
ENSCHIP00000010204TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (275 aa)
RFC3Replication factor C subunit 3. (356 aa)
POLD4Uncharacterized protein. (132 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (401 aa)
RFC4Replication factor C subunit 4. (364 aa)
DONSONDownstream neighbor of SON. (561 aa)
RFC1Replication factor C subunit 1. (1143 aa)
RAD51DDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (338 aa)
MMS22LMMS22 like, DNA repair protein. (1244 aa)
BAZ1BBromodomain adjacent to zinc finger domain 1B. (1482 aa)
ETAA1ETAA1 activator of ATR kinase. (903 aa)
HELBDNA helicase B. (1077 aa)
POLD1DNA polymerase. (1115 aa)
RPA2Replication protein A2. (270 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
PRIM2Uncharacterized protein. (219 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1070 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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