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| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (401 aa) |
| | DDX21 | Uncharacterized protein. (754 aa) |
| | DDX50 | DExD-box helicase 50. (738 aa) |
| | ENSCHIP00000000670 | DNA_pol_B_thumb domain-containing protein. (54 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (289 aa) |
| | LOC102177756 | HTH_48 domain-containing protein. (337 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (594 aa) |
| | RBBP4-2 | WD_REPEATS_REGION domain-containing protein. (425 aa) |
| | ENSCHIP00000002604 | Uncharacterized protein. (697 aa) |
| | ENSCHIP00000002654 | Uncharacterized protein. (121 aa) |
| | ENSCHIP00000002746 | D-aminoacyl-tRNA deacylase. (209 aa) |
| | LOC106502849 | Uncharacterized protein. (242 aa) |
| | ENSCHIP00000002862 | D-aminoacyl-tRNA deacylase. (209 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2281 aa) |
| | TICRR | TOPBP1 interacting checkpoint and replication regulator. (1900 aa) |
| | MGME1 | Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (342 aa) |
| | POLK | DNA polymerase kappa. (905 aa) |
| | TREX1 | Three prime repair exonuclease 1. (315 aa) |
| | ENSCHIP00000004265 | Uncharacterized protein. (393 aa) |
| | WDR18 | WD repeat domain 18. (444 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (562 aa) |
| | PURA | Purine rich element binding protein A. (322 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (469 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa) |
| | BLM | BLM RecQ like helicase. (1429 aa) |
| | GINS1 | GINS complex subunit 1. (196 aa) |
| | TWNK | Twinkle mtDNA helicase. (684 aa) |
| | TIMELESS | Timeless circadian regulator. (1206 aa) |
| | POLG | DNA polymerase gamma, catalytic subunit. (1217 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1126 aa) |
| | RECQL4 | RecQ like helicase 4. (1176 aa) |
| | NFIA | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (509 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | SSRP1 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (709 aa) |
| | POLD4 | Uncharacterized protein. (132 aa) |
| | SUPT16H | SPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa) |
| | ENSCHIP00000009163 | Uncharacterized protein. (122 aa) |
| | NFIB | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (637 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | ZNF830 | Zinc finger protein 830. (361 aa) |
| | ENSCHIP00000010204 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (275 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (863 aa) |
| | KIN | Kin17 DNA and RNA binding protein. (392 aa) |
| | RMI1 | RecQ mediated genome instability 1. (624 aa) |
| | CHAF1A | Chromatin assembly factor 1 subunit A. (955 aa) |
| | ENSCHIP00000011218 | Uncharacterized protein. (167 aa) |
| | ATRX | ATRX chromatin remodeler. (2105 aa) |
| | POLQ | DNA polymerase theta. (2587 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (931 aa) |
| | ENSCHIP00000012298 | Uncharacterized protein. (736 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1212 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (791 aa) |
| | SSBP1 | Uncharacterized protein. (148 aa) |
| | ZPR1 | ZPR1 zinc finger. (459 aa) |
| | ENSCHIP00000012571 | Uncharacterized protein. (386 aa) |
| | MCM8 | MCM domain-containing protein; Belongs to the MCM family. (832 aa) |
| | DSCC1 | Uncharacterized protein. (388 aa) |
| | NASP | Nuclear autoantigenic sperm protein. (770 aa) |
| | RNASEH2A | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (301 aa) |
| | NRM | Nurim. (262 aa) |
| | WRNIP1 | WRN helicase interacting protein 1. (640 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (649 aa) |
| | WRN | WRN RecQ like helicase. (1405 aa) |
| | FAM111B | Family with sequence similarity 111 member B. (737 aa) |
| | CDC45 | Cell division cycle 45. (524 aa) |
| | RBM48 | RNA binding motif protein 48. (362 aa) |
| | TRAIP | TRAF interacting protein. (471 aa) |
| | FANCM | FA complementation group M. (2043 aa) |
| | NFIC | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (506 aa) |
| | THOC1 | THO complex 1. (657 aa) |
| | NUCKS1 | Uncharacterized protein. (248 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1371 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (580 aa) |
| | MCMBP | Minichromosome maintenance complex binding protein. (642 aa) |
| | RBBP4 | WD_REPEATS_REGION domain-containing protein. (426 aa) |
| | PRIMPOL | Primase and DNA directed polymerase. (554 aa) |
| | FBH1 | F-box DNA helicase 1. (1048 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | TM4SF19 | Uncharacterized protein. (202 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | TTC38 | Tetratricopeptide repeat domain 38. (469 aa) |
| | CENPS | Centromere protein S. (131 aa) |
| | SIRT7 | Sirtuin 7. (405 aa) |
| | RTF2 | Replication termination factor 2. (341 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | POLA1 | DNA polymerase. (1468 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1894 aa) |
| | RFC5 | Replication factor C subunit 5. (339 aa) |
| | BOD1L1 | Uncharacterized protein. (2004 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1752 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | POLG2 | DNA polymerase gamma 2, accessory subunit. (485 aa) |
| | WDHD1 | WD repeat and HMG-box DNA binding protein 1. (1124 aa) |
| | GRWD1 | Glutamate rich WD repeat containing 1. (459 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (851 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1137 aa) |
| | DHX9 | DExH-box helicase 9. (1271 aa) |
| | POLD1 | DNA polymerase. (1115 aa) |
| | DDX23 | DEAD-box helicase 23. (820 aa) |
| | RRM1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (791 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1062 aa) |
| | MMS22L | MMS22 like, DNA repair protein. (1244 aa) |
| | LOC108638223 | Uncharacterized protein. (145 aa) |
| | E4F1 | E4F transcription factor 1. (781 aa) |
| | BAZ1A | Bromodomain adjacent to zinc finger domain 1A. (1558 aa) |
| | GMNN | Geminin DNA replication inhibitor. (186 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (1061 aa) |
| | RFC1 | Replication factor C subunit 1. (1143 aa) |
| | REPIN1 | Replication initiator 1. (534 aa) |
| | LRWD1 | Leucine rich repeats and WD repeat domain containing 1. (739 aa) |
| | POLE3 | CBFD_NFYB_HMF domain-containing protein. (147 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (808 aa) |
| | DONSON | Downstream neighbor of SON. (561 aa) |
| | TBRG1 | Transforming growth factor beta regulator 1. (411 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1274 aa) |
| | RFC4 | Replication factor C subunit 4. (364 aa) |
| | KHDC3L | MOEP19 domain-containing protein. (325 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3405 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (603 aa) |
| | RMI2 | Uncharacterized protein. (161 aa) |
| | ORC2 | Origin recognition complex subunit 2. (596 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (724 aa) |
| | CINP | Cyclin dependent kinase 2 interacting protein. (211 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (900 aa) |
| | ENSCHIP00000025462 | RNase H domain-containing protein. (226 aa) |
| | RNASEH1 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (285 aa) |
| | RBBP7 | RB binding protein 7, chromatin remodeling factor. (469 aa) |
| | NFIX | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (503 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | RRM2B | Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (351 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | ENSCHIP00000026753 | Uncharacterized protein. (107 aa) |
| | GMNC | Geminin coiled-coil domain containing. (336 aa) |
| | SRPK2 | SRSF protein kinase 2. (697 aa) |
| | RBMS1 | RNA binding motif single stranded interacting protein 1. (419 aa) |
| | RPA3 | Uncharacterized protein. (121 aa) |
| | ENSCHIP00000027862 | WD_REPEATS_REGION domain-containing protein. (404 aa) |
| | POLD3 | Uncharacterized protein. (464 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (131 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (518 aa) |
| | LIG3 | DNA ligase. (1004 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (552 aa) |
| | NOC3L | Nucleolar complex protein 3 homolog. (801 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (767 aa) |
| | OOEP | Oocyte expressed protein. (140 aa) |
| | ORC3 | Origin recognition complex subunit 3. (712 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (649 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (411 aa) |
| | DTD1 | D-aminoacyl-tRNA deacylase. (209 aa) |
| | CDK9 | Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa) |
| | DERPC | DERPC proline and glycine rich nuclear protein. (520 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (930 aa) |
| | ZRANB3 | Zinc finger RANBP2-type containing 3. (1070 aa) |
| | KAT7 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa) |
| | ENSCHIP00000031547 | HTH_48 domain-containing protein. (342 aa) |
| | PRIM2 | Uncharacterized protein. (219 aa) |
| | ENSCHIP00000031621 | Uncharacterized protein. (159 aa) |
| | RPAIN | RPA interacting protein. (219 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa) |
| | LIG1 | DNA ligase. (915 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1521 aa) |
| | PCLAF | PAF domain-containing protein. (111 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | ETAA1 | ETAA1 activator of ATR kinase. (903 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (606 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | HELB | DNA helicase B. (1077 aa) |
