STRINGSTRING
GINS4 GINS4 MCM6 MCM6 MCM4 MCM4 LOC108638223 LOC108638223 MCM7 MCM7 MCM2 MCM2 GINS2 GINS2 MCM3 MCM3 GINS3 GINS3 CDC45 CDC45 WRN WRN SSBP1 SSBP1 ENSCHIP00000011218 ENSCHIP00000011218 MCM5 MCM5 RECQL4 RECQL4 RECQL RECQL TWNK TWNK BLM BLM RECQL5 RECQL5 PURA PURA RAD51 RAD51 RPA1 RPA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
MCM4DNA helicase; Belongs to the MCM family. (851 aa)
LOC108638223Uncharacterized protein. (145 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
MCM2DNA helicase; Belongs to the MCM family. (1061 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
GINS3GINS complex subunit 3. (216 aa)
CDC45Cell division cycle 45. (524 aa)
WRNWRN RecQ like helicase. (1405 aa)
SSBP1Uncharacterized protein. (148 aa)
ENSCHIP00000011218Uncharacterized protein. (167 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
RECQL4RecQ like helicase 4. (1176 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (649 aa)
TWNKTwinkle mtDNA helicase. (684 aa)
BLMBLM RecQ like helicase. (1429 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa)
PURAPurine rich element binding protein A. (322 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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