STRINGSTRING
CCNE2 CCNE2 ORC4 ORC4 TOPBP1 TOPBP1 MCM7 MCM7 PRIM1 PRIM1 NOC3L NOC3L ORC3 ORC3 CDC6 CDC6 MCM5 MCM5 ORC1 ORC1 CDC45 CDC45 ORC5 ORC5 POLA1 POLA1 MCM6 MCM6 MCM4 MCM4 MCM2 MCM2 MCM3 MCM3 GINS3 GINS3 POLA2 POLA2 MCM10 MCM10 CCNE1 CCNE1 PRIM2 PRIM2 ORC6 ORC6 GMNC GMNC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1521 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (401 aa)
NOC3LNucleolar complex protein 3 homolog. (801 aa)
ORC3Origin recognition complex subunit 3. (712 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (562 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (863 aa)
CDC45Cell division cycle 45. (524 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
POLA1DNA polymerase. (1468 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
MCM4DNA helicase; Belongs to the MCM family. (851 aa)
MCM2DNA helicase; Belongs to the MCM family. (1061 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
GINS3GINS complex subunit 3. (216 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (603 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (900 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (411 aa)
PRIM2Uncharacterized protein. (219 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
GMNCGeminin coiled-coil domain containing. (336 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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