47 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CETN1	Centrin 1. (172 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
	ERCC1	ERCC excision repair 1, endonuclease non-catalytic subunit. (294 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	USP7	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1103 aa)
	HUS1	Checkpoint protein; Belongs to the HUS1 family. (280 aa)
	POLD3	Uncharacterized protein. (464 aa)
	RPA3	Uncharacterized protein. (121 aa)
	ERCC2	ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
	OGG1	8-oxoguanine DNA glycosylase. (345 aa)
	RAD23B	RAD23 homolog B, nucleotide excision repair protein. (408 aa)
	ERCC4	ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
	GTF2H4	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (463 aa)
	MNAT1	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
	FANCC	Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (568 aa)
	DDB2	Damage specific DNA binding protein 2. (411 aa)
	BRCA2	BRCA2 DNA repair associated. (3405 aa)
	FAN1	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1022 aa)
	BIVM	Uncharacterized protein. (502 aa)
	UVSSA	UV stimulated scaffold protein A. (663 aa)
	CETN2	Centrin 2. (166 aa)
	RPA2	Replication protein A2. (270 aa)
	POLD1	DNA polymerase. (1115 aa)
	COMMD1	Copper metabolism domain containing 1. (188 aa)
	XPC	XPC complex subunit, DNA damage recognition and repair factor. (877 aa)
	RAD23A	RAD23 homolog A, nucleotide excision repair protein. (368 aa)
	SLX4	SLX4 structure-specific endonuclease subunit. (1752 aa)
	ERCC8	ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (397 aa)
	BRIP1	BRCA1 interacting protein C-terminal helicase 1. (1217 aa)
	KAT5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
	GTF2H1	General transcription factor IIH subunit 1. (548 aa)
	NTHL1	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (313 aa)
	ERCC3	ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
	ERCC5	ERCC excision repair 5, endonuclease. (1190 aa)
	LOC102185505	General transcription factor IIH subunit. (388 aa)
	GTF2H3	General transcription factor IIH subunit 3. (307 aa)
	POLR2I	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
	XAB2	XPA binding protein 2. (892 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (732 aa)
	XPA	XPA, DNA damage recognition and repair factor. (273 aa)
	ERCC6	ERCC excision repair 6, chromatin remodeling factor. (1481 aa)
	POLK	DNA polymerase kappa. (905 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2281 aa)
	ENSCHIP00000002654	Uncharacterized protein. (121 aa)
	POLL	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (594 aa)
	LIG4	DNA ligase. (911 aa)
	GTF2H5	General transcription factor IIH subunit 5. (85 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BIVM	BRCA2	ENSCHIP00000023511	ENSCHIP00000024039	Uncharacterized protein.	BRCA2 DNA repair associated.	0.719
BIVM	BRIP1	ENSCHIP00000023511	ENSCHIP00000015293	Uncharacterized protein.	BRCA1 interacting protein C-terminal helicase 1.	0.517
BIVM	CETN1	ENSCHIP00000023511	ENSCHIP00000003031	Uncharacterized protein.	Centrin 1.	0.438
BIVM	CETN2	ENSCHIP00000023511	ENSCHIP00000020516	Uncharacterized protein.	Centrin 2.	0.610
BIVM	DDB2	ENSCHIP00000023511	ENSCHIP00000024487	Uncharacterized protein.	Damage specific DNA binding protein 2.	0.541
BIVM	ENSCHIP00000002654	ENSCHIP00000023511	ENSCHIP00000002654	Uncharacterized protein.	Uncharacterized protein.	0.467
BIVM	ERCC1	ENSCHIP00000023511	ENSCHIP00000031141	Uncharacterized protein.	ERCC excision repair 1, endonuclease non-catalytic subunit.	0.725
BIVM	ERCC2	ENSCHIP00000023511	ENSCHIP00000026861	Uncharacterized protein.	ERCC excision repair 2, TFIIH core complex helicase subunit.	0.891
BIVM	ERCC3	ENSCHIP00000023511	ENSCHIP00000013017	Uncharacterized protein.	ERCC excision repair 3, TFIIH core complex helicase subunit.	0.905
BIVM	ERCC4	ENSCHIP00000023511	ENSCHIP00000026065	Uncharacterized protein.	ERCC excision repair 4, endonuclease catalytic subunit.	0.809
BIVM	ERCC5	ENSCHIP00000023511	ENSCHIP00000012626	Uncharacterized protein.	ERCC excision repair 5, endonuclease.	0.814
BIVM	ERCC6	ENSCHIP00000023511	ENSCHIP00000005910	Uncharacterized protein.	ERCC excision repair 6, chromatin remodeling factor.	0.945
BIVM	GTF2H1	ENSCHIP00000023511	ENSCHIP00000013203	Uncharacterized protein.	General transcription factor IIH subunit 1.	0.928
BIVM	GTF2H3	ENSCHIP00000023511	ENSCHIP00000009508	Uncharacterized protein.	General transcription factor IIH subunit 3.	0.630
BIVM	GTF2H4	ENSCHIP00000023511	ENSCHIP00000025980	Uncharacterized protein.	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.	0.551
BIVM	GTF2H5	ENSCHIP00000023511	ENSCHIP00000000855	Uncharacterized protein.	General transcription factor IIH subunit 5.	0.642
BIVM	HUS1	ENSCHIP00000023511	ENSCHIP00000028772	Uncharacterized protein.	Checkpoint protein; Belongs to the HUS1 family.	0.584
BIVM	LIG4	ENSCHIP00000023511	ENSCHIP00000000867	Uncharacterized protein.	DNA ligase.	0.634
BIVM	LOC102185505	ENSCHIP00000023511	ENSCHIP00000009578	Uncharacterized protein.	General transcription factor IIH subunit.	0.827
BIVM	NTHL1	ENSCHIP00000023511	ENSCHIP00000013196	Uncharacterized protein.	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.	0.473