Your Input: | |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (280 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (649 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (533 aa) |
| | MTA1 | Metastasis associated 1. (827 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (332 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (930 aa) |
| | MFSD11 | Major facilitator superfamily domain containing 11. (449 aa) |
| | NABP1 | Nucleic acid binding protein 1. (205 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (294 aa) |
| | ENSCHIP00000031435 | Uncharacterized protein. (77 aa) |
| | INTS3 | Integrator complex subunit 3. (1041 aa) |
| | ENSCHIP00000031547 | HTH_48 domain-containing protein. (342 aa) |
| | BRCC3 | MPN domain-containing protein. (288 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (916 aa) |
| | HMCES | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (374 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase. (1020 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (851 aa) |
| | GGN | Gametogenetin. (676 aa) |
| | SMC5 | AAA_23 domain-containing protein. (1104 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1752 aa) |
| | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (397 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (410 aa) |
| | DCLRE1A | DNA cross-link repair 1A. (1051 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | TM4SF19 | Uncharacterized protein. (202 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | FBH1 | F-box DNA helicase 1. (1048 aa) |
| | INIP | INTS3 and NABP interacting protein. (102 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (580 aa) |
| | PARP9 | Poly(ADP-ribose) polymerase family member 9. (855 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1371 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (525 aa) |
| | AP5Z1 | Adaptor related protein complex 5 subunit zeta 1. (807 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1217 aa) |
| | SLFNL1 | Schlafen like 1. (407 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (332 aa) |
| | NUCKS1 | Uncharacterized protein. (248 aa) |
| | FANCB | Uncharacterized protein. (447 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (710 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | NABP2 | Nucleic acid binding protein 2. (175 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa) |
| | TDP2 | Endo/exonuclease/phosphatase domain-containing protein. (330 aa) |
| | RAD51C | RAD51 paralog C. (371 aa) |
| | FANCM | FA complementation group M. (2043 aa) |
| | APLF | Aprataxin and PNKP like factor. (480 aa) |
| | CDC45 | Cell division cycle 45. (524 aa) |
| | WRN | WRN RecQ like helicase. (1405 aa) |
| | AUNIP | Aurora kinase A and ninein interacting protein. (357 aa) |
| | NHEJ1 | Non-homologous end joining factor 1. (299 aa) |
| | RAD51B | RAD51 paralog B. (270 aa) |
| | MCM8 | MCM domain-containing protein; Belongs to the MCM family. (832 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1002 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (791 aa) |
| | C7H19orf57 | Uncharacterized protein. (481 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (326 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4117 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (931 aa) |
| | POLQ | DNA polymerase theta. (2587 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (148 aa) |
| | YY1 | YY1 transcription factor. (415 aa) |
| | MEIOB | Meiosis specific with OB-fold. (467 aa) |
| | ENSCHIP00000010726 | Uncharacterized protein. (490 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (889 aa) |
| | APTX | Aprataxin. (368 aa) |
| | SMARCAD1 | Uncharacterized protein. (1028 aa) |
| | ESCO2 | Establishment of sister chromatid cohesion N-acetyltransferase 2. (610 aa) |
| | RMI1 | RecQ mediated genome instability 1. (624 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (607 aa) |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1. (612 aa) |
| | AP5S1 | Adaptor related protein complex 5 subunit sigma 1. (200 aa) |
| | IFFO2 | Intermediate filament family orphan 2; Belongs to the intermediate filament family. (519 aa) |
| | ENSCHIP00000009605 | Uncharacterized protein. (61 aa) |
| | LOC102189098 | MPN domain-containing protein. (291 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | MEIOC | Meiosis specific with coiled-coil domain. (960 aa) |
| | NIPBL | Nipped-B protein. (2804 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa) |
| | RECQL4 | RecQ like helicase 4. (1176 aa) |
| | DDX1 | DEAD-box helicase 1. (740 aa) |
| | ACTR5 | Actin related protein 5; Belongs to the actin family. (615 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (195 aa) |
| | RAD21 | RAD21 cohesin complex component. (630 aa) |
| | BLM | BLM RecQ like helicase. (1429 aa) |
| | INO80 | INO80 complex ATPase subunit. (1566 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1966 aa) |
| | SWSAP1 | SWIM-type zinc finger 7 associated protein 1. (250 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (1116 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1194 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1481 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa) |
| | ZGRF1 | Uncharacterized protein. (1855 aa) |
| | WDR48 | WD repeat domain 48. (678 aa) |
| | MORF4L1 | Mortality factor 4 like 1. (363 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (416 aa) |
| | TNKS1BP1 | Tankyrase 1 binding protein 1. (1648 aa) |
| | MARF1 | Meiosis regulator and mRNA stability factor 1. (1740 aa) |
| | FSBP | Uncharacterized protein. (909 aa) |
| | ENSCHIP00000003676 | RECA_2 domain-containing protein. (278 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (504 aa) |
| | ENSCHIP00000003493 | MPN domain-containing protein. (262 aa) |
| | PAXX | PAXX non-homologous end joining factor. (201 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1332 aa) |
| | RNF169 | Ring finger protein 169. (708 aa) |
| | LOC106502849 | Uncharacterized protein. (242 aa) |
| | ENSCHIP00000002654 | Uncharacterized protein. (121 aa) |
| | EPC1 | Enhancer of polycomb homolog. (842 aa) |
| | HSF2BP | Heat shock transcription factor 2 binding protein. (338 aa) |
| | DNTT | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (501 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (594 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (383 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | ENSCHIP00000001380 | Reverse transcriptase domain-containing protein. (704 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | LOC102177756 | HTH_48 domain-containing protein. (337 aa) |
| | ENSCHIP00000000670 | DNA_pol_B_thumb domain-containing protein. (54 aa) |
| | SMCHD1 | Structural maintenance of chromosomes flexible hinge domain containing 1. (1987 aa) |
| | LOC106503984 | Uncharacterized protein. (292 aa) |
| | ENSCHIP00000000047 | RING-type domain-containing protein. (101 aa) |
| | SIRT6 | Sirtuin 6. (335 aa) |
| | ENSCHIP00000031621 | Uncharacterized protein. (159 aa) |
| | MBTD1 | Mbt domain containing 1. (628 aa) |
| | UVRAG | UV radiation resistance associated. (699 aa) |
| | PSMD14 | MPN domain-containing protein. (310 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa) |
| | FANCD2 | FA complementation group D2. (1423 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | CDC7 | Cell division cycle 7. (576 aa) |
| | IFFO1 | Intermediate filament family orphan 1; Belongs to the intermediate filament family. (562 aa) |
| | ANKLE1 | Ankyrin repeat and LEM domain containing 1. (487 aa) |
| | CYREN | Cell cycle regulator of NHEJ. (144 aa) |
| | MMS22L | MMS22 like, DNA repair protein. (1244 aa) |
| | RAD51D | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (338 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (1061 aa) |
| | NSMCE1 | NSE1 homolog, SMC5-SMC6 complex component. (266 aa) |
| | RAD54L | RAD54 like. (749 aa) |
| | REC8 | REC8 meiotic recombination protein. (564 aa) |
| | HELQ | Helicase, POLQ like. (1115 aa) |
| | SFR1 | SWI5 dependent homologous recombination repair protein 1. (232 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (808 aa) |
| | SEM1 | Uncharacterized protein. (63 aa) |
| | SETX | Senataxin. (2659 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (632 aa) |
| | ZFYVE26 | Zinc finger FYVE-type containing 26. (2534 aa) |
| | PRPF19 | Pre-mRNA processing factor 19. (504 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (341 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (267 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1022 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3405 aa) |
| | RMI2 | Uncharacterized protein. (161 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (724 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (946 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (736 aa) |
| | RAD21L1 | RAD21 cohesin complex component like 1. (554 aa) |
| | VCP | Valosin containing protein; Belongs to the AAA ATPase family. (816 aa) |
| | CCDC155 | Coiled-coil domain containing 155. (505 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (606 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (277 aa) |
| | SWI5 | SWI5 homologous recombination repair protein. (223 aa) |
| | KDM2A | Lysine demethylase 2A. (1168 aa) |
| | ENSCHIP00000020042 | MPN domain-containing protein. (245 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1137 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1062 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | TRIP13 | Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (432 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (681 aa) |
| | ZBTB7A | Zinc finger and BTB domain containing 7A. (602 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (795 aa) |
| | POLM | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (488 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3134 aa) |
| | SFPQ | Splicing factor proline and glutamine rich. (711 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa) |
| | ENSCHIP00000027563 | MPN domain-containing protein. (302 aa) |
| | RPA3 | Uncharacterized protein. (121 aa) |
| | CHEK2 | Checkpoint kinase 2. (534 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (522 aa) |
| | DTX3L | Deltex E3 ubiquitin ligase 3L. (738 aa) |
| | DCLRE1B | DNA cross-link repair 1B. (542 aa) |
| | LIG3 | DNA ligase. (1004 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (552 aa) |
| | SPO11 | SPO11 initiator of meiotic double stranded breaks. (395 aa) |
| | ZSWIM7 | Zinc finger SWIM-type containing 7. (141 aa) |
