STRINGSTRING
CARD11 CARD11 TLR7 TLR7 BTK BTK IRAK2 IRAK2 ABL1 ABL1 NLRC3 NLRC3 NKIRAS2 NKIRAS2 AVPR2 AVPR2 NFKBIL1 NFKBIL1 ERC1 ERC1 DAB2IP DAB2IP TIFAB TIFAB TNF TNF FYN FYN TANK TANK ENSCHIP00000006481 ENSCHIP00000006481 TIFA TIFA EDNRB EDNRB BCL10 BCL10 MAP3K7 MAP3K7 EDN1 EDN1 IKBKE IKBKE NKIRAS1 NKIRAS1 RELB RELB AKT1 AKT1 TLR9 TLR9 NOD2 NOD2 CTNNB1 CTNNB1 TLR2 TLR2 TIRAP TIRAP AJUBA AJUBA ASH1L ASH1L ROCK2 ROCK2 SNIP1 SNIP1 IKBKB IKBKB TNFSF11 TNFSF11 RELA RELA TLR3 TLR3 TRAF6 TRAF6 ROCK1 ROCK1 BCL3 BCL3 RIPK3 RIPK3 TLR8 TLR8 TBKBP1 TBKBP1 AZI2 AZI2 CHUK CHUK MAP3K14 MAP3K14 MYD88 MYD88 FAIM FAIM IRAK1BP1 IRAK1BP1 TLR4 TLR4 RIPK2 RIPK2 NOD1 NOD1 DEFB124 DEFB124 EDNRA EDNRA REL REL ENSCHIP00000022451 ENSCHIP00000022451 HACD3 HACD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CARD11Caspase recruitment domain family member 11. (1154 aa)
TLR7TIR domain-containing protein. (1054 aa)
BTKTyrosine-protein kinase. (658 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (622 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
NLRC3NLR family CARD domain containing 3. (1111 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (191 aa)
AVPR2Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (370 aa)
NFKBIL1NFKB inhibitor like 1. (381 aa)
ERC1ELKS/RAB6-interacting/CAST family member 1. (1116 aa)
DAB2IPDAB2 interacting protein. (1198 aa)
TIFABTIFA inhibitor. (197 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
FYNTyrosine-protein kinase. (537 aa)
TANKTBD domain-containing protein. (422 aa)
ENSCHIP00000006481ANK_REP_REGION domain-containing protein. (123 aa)
TIFATRAF interacting protein with forkhead associated domain. (185 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (441 aa)
BCL10BCL10 immune signaling adaptor. (230 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
EDN1Endothelin 1. (202 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (712 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
RELBRELB proto-oncogene, NF-kB subunit. (645 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
TLR9TIR domain-containing protein. (1070 aa)
NOD2Uncharacterized protein. (982 aa)
CTNNB1Catenin beta 1. (781 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (794 aa)
TIRAPTIR domain containing adaptor protein. (228 aa)
AJUBAAjuba LIM protein. (571 aa)
ASH1LASH1 like histone lysine methyltransferase. (2968 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
SNIP1Smad nuclear interacting protein 1. (429 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (316 aa)
RELARELA proto-oncogene, NF-kB subunit. (571 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (918 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
BCL3BCL3 transcription coactivator. (454 aa)
RIPK3Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (243 aa)
TLR8TIR domain-containing protein; Belongs to the Toll-like receptor family. (1085 aa)
TBKBP1TBK1 binding protein 1. (627 aa)
AZI25-azacytidine induced 2. (406 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (740 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (953 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
FAIMFas apoptotic inhibitory molecule. (242 aa)
IRAK1BP1Interleukin 1 receptor associated kinase 1 binding protein 1. (260 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (537 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (954 aa)
DEFB124Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (68 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
RELREL proto-oncogene, NF-kB subunit. (591 aa)
ENSCHIP00000022451TBD domain-containing protein. (430 aa)
HACD3Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (364 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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