(68 nodes) Synapse assembly network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NLGN3	Neuroligin 3. (789 aa)
	NLGN1	Neuroligin 1. (509 aa)
	ENSCHIP00000033531	Uncharacterized protein. (561 aa)
	ENSCHIP00000033658	SUEL-type lectin domain-containing protein. (144 aa)
	FBXO45	F-box protein 45. (281 aa)
	ENSCHIP00000000779	Uncharacterized protein. (79 aa)
	ENSCHIP00000000990	Latrophilin domain-containing protein. (184 aa)
	KIRREL3	Kirre like nephrin family adhesion molecule 3. (774 aa)
	LRRC4	Leucine rich repeat containing 4. (652 aa)
	SLITRK3	SLIT and NTRK like family member 3. (980 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (302 aa)
	BDNF	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (258 aa)
	NLGN4X	COesterase domain-containing protein. (815 aa)
	SLITRK1	SLIT and NTRK like family member 1. (696 aa)
	FLRT3	Fibronectin leucine rich transmembrane protein 3. (649 aa)
	CNTN5	Contactin 5. (975 aa)
	PLXND1	Plexin D1. (1926 aa)
	CDHR2	Cadherin related family member 2. (1349 aa)
	CLSTN3	Calsyntenin 3. (957 aa)
	SLITRK6	SLIT and NTRK like family member 6. (842 aa)
	PCDH17	Protocadherin 17. (1189 aa)
	PCLO	Piccolo presynaptic cytomatrix protein. (5197 aa)
	GNPAT	Dihydroxyacetone phosphate acyltransferase. (680 aa)
	NTNG2	Netrin G2. (573 aa)
	GJA10	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (522 aa)
	GPM6A	Glycoprotein M6A. (278 aa)
	DVL1	Dishevelled segment polarity protein 1. (682 aa)
	MYPN	Myopalladin. (1320 aa)
	BSN	Bassoon presynaptic cytomatrix protein. (3902 aa)
	DBNL	Drebrin like. (429 aa)
	TTN	Uncharacterized protein. (2149 aa)
	ADD2	Adducin 2. (715 aa)
	CBLN4	Cerebellin 4 precursor. (201 aa)
	CBLN1	Cerebellin 1 precursor. (193 aa)
	HAPLN4	Hyaluronan and proteoglycan link protein 4. (402 aa)
	SDK2	Sidekick cell adhesion molecule 2. (2331 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains 3. (1704 aa)
	CDH1	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (903 aa)
	PLXNB1	Plexin B1. (2140 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
	CBLN2	Cerebellin 2 precursor. (272 aa)
	GABRA1	Gamma-aminobutyric acid type A receptor alpha1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
	NPAS4	Neuronal PAS domain protein 4. (801 aa)
	SDK1	Sidekick cell adhesion molecule 1. (2045 aa)
	GRID2	Glutamate ionotropic receptor delta type subunit 2. (922 aa)
	ADGRL3	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family. (893 aa)
	NLGN2	Neuroligin 2. (817 aa)
	NPTN	Neuroplastin. (361 aa)
	GABRB3	Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (493 aa)
	IGFN1	Uncharacterized protein. (1295 aa)
	LGI2	Leucine rich repeat LGI family member 2. (554 aa)
	SRGAP2	Uncharacterized protein. (1084 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	GABRG2	Gamma-aminobutyric acid type A receptor gamma2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (475 aa)
	MECP2	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (481 aa)
	RAB29	RAB29, member RAS oncogene family. (203 aa)
	GPM6B	Glycoprotein M6B. (326 aa)
	LRRTM3	Leucine rich repeat transmembrane neuronal 3. (581 aa)
	ADGRF1	Adhesion G protein-coupled receptor F1; Belongs to the G-protein coupled receptor 2 family. (992 aa)
	LRP4	LDL receptor related protein 4. (1901 aa)
	GABRB2	Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (474 aa)
	ERBB4	Protein kinase domain-containing protein. (462 aa)
	SPTBN2	Spectrin beta chain; Belongs to the spectrin family. (2392 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	ASIC2	Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (492 aa)
	ZDHHC12	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (268 aa)
	GABRA2	Gamma-aminobutyric acid type A receptor alpha2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (451 aa)
	APP	Amyloid beta precursor protein. (770 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADD2	SPTBN2	ENSCHIP00000016125	ENSCHIP00000031448	Adducin 2.	Spectrin beta chain; Belongs to the spectrin family.	0.401
ADGRL3	ENSCHIP00000000990	ENSCHIP00000022792	ENSCHIP00000000990	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	Latrophilin domain-containing protein.	0.919
ADGRL3	ENSCHIP00000033658	ENSCHIP00000022792	ENSCHIP00000033658	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	SUEL-type lectin domain-containing protein.	0.918
ADGRL3	FLRT3	ENSCHIP00000022792	ENSCHIP00000004373	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	Fibronectin leucine rich transmembrane protein 3.	0.942
ADGRL3	LRRC4	ENSCHIP00000022792	ENSCHIP00000002572	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	Leucine rich repeat containing 4.	0.668
ADGRL3	LRRTM3	ENSCHIP00000022792	ENSCHIP00000027735	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	Leucine rich repeat transmembrane neuronal 3.	0.678
ADGRL3	SLITRK1	ENSCHIP00000022792	ENSCHIP00000004086	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	SLIT and NTRK like family member 1.	0.668
ADGRL3	SLITRK3	ENSCHIP00000022792	ENSCHIP00000002706	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	SLIT and NTRK like family member 3.	0.679
ADGRL3	SLITRK6	ENSCHIP00000022792	ENSCHIP00000007832	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	SLIT and NTRK like family member 6.	0.667
APP	BDNF	ENSCHIP00000032622	ENSCHIP00000003028	Amyloid beta precursor protein.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.649
APP	CDK5	ENSCHIP00000032622	ENSCHIP00000031665	Amyloid beta precursor protein.	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	0.600
APP	CNTN5	ENSCHIP00000032622	ENSCHIP00000004508	Amyloid beta precursor protein.	Contactin 5.	0.777
APP	LRP4	ENSCHIP00000032622	ENSCHIP00000029758	Amyloid beta precursor protein.	LDL receptor related protein 4.	0.403
BDNF	APP	ENSCHIP00000003028	ENSCHIP00000032622	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Amyloid beta precursor protein.	0.649
BDNF	CDK5	ENSCHIP00000003028	ENSCHIP00000031665	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	0.760
BDNF	ERBB4	ENSCHIP00000003028	ENSCHIP00000031292	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Protein kinase domain-containing protein.	0.817
BDNF	GABRA1	ENSCHIP00000003028	ENSCHIP00000020888	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Gamma-aminobutyric acid type A receptor alpha1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.431
BDNF	MECP2	ENSCHIP00000003028	ENSCHIP00000026916	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.914
BDNF	NLGN1	ENSCHIP00000003028	ENSCHIP00000033301	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Neuroligin 1.	0.432
BDNF	NLGN3	ENSCHIP00000003028	ENSCHIP00000032639	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Neuroligin 3.	0.430