(109 nodes) Mesoderm development network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	INHBA	Inhibin beta A subunit. (425 aa)
	ENSCHIP00000000031	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (307 aa)
	ENSCHIP00000000268	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (310 aa)
	NODAL	Nodal growth differentiation factor. (346 aa)
	LOC108634558	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (294 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	POFUT2	Protein O-fucosyltransferase 2. (429 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (219 aa)
	POU4F1	POU domain protein. (421 aa)
	ENSCHIP00000002449	Uncharacterized protein; Belongs to the eukaryotic ribosomal protein eL38 family. (60 aa)
	CTDNEP1	CTD nuclear envelope phosphatase 1. (244 aa)
	ITGB4	Integrin beta. (1850 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (256 aa)
	DLL3	Delta like canonical Notch ligand 3. (595 aa)
	ENSCHIP00000005210	Uncharacterized protein. (237 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (446 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	PALB2	Partner and localizer of BRCA2. (1194 aa)
	AXIN1	Axin 1. (867 aa)
	MSGN1	Mesogenin 1. (191 aa)
	SIX2	SIX homeobox 2. (296 aa)
	LOC108634559	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (324 aa)
	LOC108634813	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (310 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	TBXT	T-box transcription factor T. (435 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	PRKAR1A	Protein kinase cAMP-dependent type I regulatory subunit alpha. (380 aa)
	SRF	Serum response factor. (509 aa)
	LDB1	LIM domain binding 1. (411 aa)
	NANOG	Homeobox domain-containing protein. (300 aa)
	ENSCHIP00000009343	Uncharacterized protein; Belongs to the eukaryotic ribosomal protein eL38 family. (69 aa)
	TAF10	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
	TBX3	T-box transcription factor 3. (749 aa)
	ENSCHIP00000009539	Uncharacterized protein; Belongs to the eukaryotic ribosomal protein eL38 family. (60 aa)
	POGLUT1	Protein O-glucosyltransferase 1. (392 aa)
	TBX6	T-box transcription factor 6. (437 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	HMGA2	Uncharacterized protein. (104 aa)
	TBX19	T-box transcription factor 19. (446 aa)
	NF2	FERM domain-containing protein. (612 aa)
	EPB41L5	FERM domain-containing protein. (505 aa)
	ENSCHIP00000012536	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (311 aa)
	SNAI1	Snail family transcriptional repressor 1. (264 aa)
	IRX3	Iroquois homeobox 3. (503 aa)
	ITGA3	Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
	FOXH1	Forkhead box H1. (360 aa)
	EPHA2	EPH receptor A2. (975 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	ENSCHIP00000015549	Uncharacterized protein; Belongs to the eukaryotic ribosomal protein eL38 family. (71 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
	GPI	Glucose-6-phosphate isomerase; Belongs to the GPI family. (557 aa)
	LOC108634563	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (319 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (360 aa)
	SCX	Scleraxis bHLH transcription factor. (201 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	OVOL1	Ovo like transcriptional repressor 1. (267 aa)
	YAP1	Yes associated protein 1. (503 aa)
	KDM6B	Lysine demethylase 6B. (1685 aa)
	ITGA8	Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (786 aa)
	HNF1A	HNF1 homeobox A. (631 aa)
	ENSCHIP00000019018	Sec8_exocyst domain-containing protein. (413 aa)
	TCF15	Transcription factor 15. (197 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2556 aa)
	MESP2	Mesoderm posterior bHLH transcription factor 2. (366 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	FOXF1	Forkhead box F1. (391 aa)
	SMAD4	Mothers against decapentaplegic homolog. (513 aa)
	ENSCHIP00000021059	Uncharacterized protein. (63 aa)
	OSR1	Odd-skipped related transcription factor 1. (267 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	HOXA11	Homeobox A11. (317 aa)
	TXNRD1	Thioredoxin reductase 1. (587 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	ENSCHIP00000023862	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (302 aa)
	ZIC3	Zic family member 3. (465 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
	LHX1	LIM homeobox 1. (406 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (338 aa)
	SFRP2	Secreted frizzled related protein 2. (294 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
	PPP2CA	Serine/threonine-protein phosphatase. (309 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (681 aa)
	TAL1	TAL bHLH transcription factor 1, erythroid differentiation factor. (328 aa)
	EXOC4	Uncharacterized protein. (408 aa)
	SSBP3	Single stranded DNA binding protein 3. (388 aa)
	AMH	Anti-Mullerian hormone. (575 aa)
	ENSCHIP00000029353	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (307 aa)
	APELA	Uncharacterized protein. (54 aa)
	TLX2	T cell leukemia homeobox 2. (284 aa)
	LHX2	Uncharacterized protein. (422 aa)
	EOMES	Eomesodermin. (701 aa)
	ETV2	ETS domain-containing protein. (153 aa)
	LEF1	HMG box domain-containing protein. (430 aa)
	EXT2	Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (737 aa)
	ENSCHIP00000031826	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (315 aa)
	TEAD2	TEA domain transcription factor 2. (448 aa)
	KDM6A	Lysine demethylase 6A. (1386 aa)
	NUP133	Nucleoporin 133. (1156 aa)
	CRB2	Crumbs cell polarity complex component 2. (1275 aa)
	TWSG1	Twisted gastrulation BMP signaling modulator 1. (223 aa)
	ARMC5	Armadillo repeat containing 5. (939 aa)
	ITGA2	Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1179 aa)
	RPL38	Uncharacterized protein; Belongs to the eukaryotic ribosomal protein eL38 family. (69 aa)
	ENSCHIP00000033272	FERM domain-containing protein. (580 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMH	BMP4	ENSCHIP00000028883	ENSCHIP00000023678	Anti-Mullerian hormone.	Bone morphogenetic protein 4.	0.434
AMH	BMP7	ENSCHIP00000028883	ENSCHIP00000006043	Anti-Mullerian hormone.	Bone morphogenetic protein 7.	0.412
AMH	BMPR1A	ENSCHIP00000028883	ENSCHIP00000000640	Anti-Mullerian hormone.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.578
AMH	BMPR2	ENSCHIP00000028883	ENSCHIP00000022191	Anti-Mullerian hormone.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.491
AMH	INHBA	ENSCHIP00000028883	ENSCHIP00000031622	Anti-Mullerian hormone.	Inhibin beta A subunit.	0.778
AMH	SMAD2	ENSCHIP00000028883	ENSCHIP00000022106	Anti-Mullerian hormone.	Mothers against decapentaplegic homolog.	0.446
AMH	SMAD3	ENSCHIP00000028883	ENSCHIP00000011729	Anti-Mullerian hormone.	Mothers against decapentaplegic homolog.	0.404
AMH	SMAD4	ENSCHIP00000028883	ENSCHIP00000020573	Anti-Mullerian hormone.	Mothers against decapentaplegic homolog.	0.430
AXIN1	BMPR1A	ENSCHIP00000006499	ENSCHIP00000000640	Axin 1.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.409
AXIN1	LEF1	ENSCHIP00000006499	ENSCHIP00000030629	Axin 1.	HMG box domain-containing protein.	0.812
AXIN1	PPP2CA	ENSCHIP00000006499	ENSCHIP00000027969	Axin 1.	Serine/threonine-protein phosphatase.	0.534
AXIN1	SFRP2	ENSCHIP00000006499	ENSCHIP00000026721	Axin 1.	Secreted frizzled related protein 2.	0.469
AXIN1	SMAD3	ENSCHIP00000006499	ENSCHIP00000011729	Axin 1.	Mothers against decapentaplegic homolog.	0.409
AXIN1	SMAD4	ENSCHIP00000006499	ENSCHIP00000020573	Axin 1.	Mothers against decapentaplegic homolog.	0.479
AXIN1	WNT11	ENSCHIP00000006499	ENSCHIP00000024696	Axin 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.495
AXIN1	WNT3	ENSCHIP00000006499	ENSCHIP00000020033	Axin 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.693
AXIN1	WNT3A	ENSCHIP00000006499	ENSCHIP00000015590	Axin 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.838
AXIN1	WNT5A	ENSCHIP00000006499	ENSCHIP00000015533	Axin 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.702
BMP4	AMH	ENSCHIP00000023678	ENSCHIP00000028883	Bone morphogenetic protein 4.	Anti-Mullerian hormone.	0.434
BMP4	BMP7	ENSCHIP00000023678	ENSCHIP00000006043	Bone morphogenetic protein 4.	Bone morphogenetic protein 7.	0.778