STRINGSTRING
LOC108634345 LOC108634345 RAD51C RAD51C FANCM FANCM CHD5 CHD5 WRN WRN PIF1 PIF1 WRNIP1 WRNIP1 ERCC3 ERCC3 RAD51B RAD51B CECR2 CECR2 DSCC1 DSCC1 MCM8 MCM8 ENSCHIP00000012571 ENSCHIP00000012571 MSH6 MSH6 RTEL1 RTEL1 CHD1L CHD1L POLQ POLQ SMARCA5 SMARCA5 ATRX ATRX MPHOSPH9 MPHOSPH9 PMS1 PMS1 HELQ HELQ RAD54L RAD54L MSH5 MSH5 RFC1 RFC1 MCM2 MCM2 RAD51D RAD51D DQX1 DQX1 CHD4 CHD4 RFC4 RFC4 ERCC6L2 ERCC6L2 CHD9 CHD9 XRCC3 XRCC3 TOP2B TOP2B MRE11 MRE11 MSH2 MSH2 XRCC5 XRCC5 CHD2 CHD2 ERCC2 ERCC2 ENSCHIP00000027862 ENSCHIP00000027862 ASCC3 ASCC3 CDK7 CDK7 SPO11 SPO11 HLTF HLTF XRCC2 XRCC2 RECQL RECQL RUVBL2 RUVBL2 DDX3X DDX3X RAD17 RAD17 TTF2 TTF2 MCM3 MCM3 RSF1 RSF1 DMC1 DMC1 SMARCAL1 SMARCAL1 CHD1 CHD1 ZRANB3 ZRANB3 SMARCA2 SMARCA2 HELB HELB MCM7 MCM7 GTF2F2 GTF2F2 RAD51 RAD51 MSH3 MSH3 MSH4 MSH4 CHD8 CHD8 ENSCHIP00000000025 ENSCHIP00000000025 SUPV3L1 SUPV3L1 NAV2 NAV2 RBBP4-2 RBBP4-2 ENSCHIP00000002436 ENSCHIP00000002436 RAD50 RAD50 ENSCHIP00000003676 ENSCHIP00000003676 FSBP FSBP ENSCHIP00000004265 ENSCHIP00000004265 SUB1 SUB1 SHPRH SHPRH RAD54L2 RAD54L2 CHTF18 CHTF18 RFC2 RFC2 RECQL5 RECQL5 MLH3 MLH3 SMARCA1 SMARCA1 ERCC6 ERCC6 ERCC6L ERCC6L INO80 INO80 BLM BLM TWNK TWNK UPF1 UPF1 DDX1 DDX1 ENSCHIP00000007747 ENSCHIP00000007747 RECQL4 RECQL4 ENSCHIP00000007823 ENSCHIP00000007823 SMC3 SMC3 MCM5 MCM5 IGHMBP2 IGHMBP2 EP400 EP400 CHD7 CHD7 SRCAP SRCAP MLH1 MLH1 TOP2A TOP2A RFC3 RFC3 BPTF BPTF XRCC6 XRCC6 C17orf64 C17orf64 SMARCAD1 SMARCAD1 RUVBL1 RUVBL1 DNA2 DNA2 DHX9 DHX9 ENSCHIP00000019703 ENSCHIP00000019703 ENSCHIP00000019473 ENSCHIP00000019473 MCM9 MCM9 MCM4 MCM4 CHD6 CHD6 SMC5 SMC5 MCM6 MCM6 DHX36 DHX36 PMS2 PMS2 ATAD5 ATAD5 CHD3 CHD3 LOC108637664 LOC108637664 TM4SF19 TM4SF19 FBH1 FBH1 RBBP4 RBBP4 BRIP1 BRIP1 G3BP1 G3BP1 DDX11 DDX11 CEP41 CEP41 SMARCA4 SMARCA4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108634345Uncharacterized protein. (206 aa)
RAD51CRAD51 paralog C. (371 aa)
FANCMFA complementation group M. (2043 aa)
CHD5Chromodomain helicase DNA binding protein 5. (1996 aa)
WRNWRN RecQ like helicase. (1405 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (649 aa)
WRNIP1WRN helicase interacting protein 1. (640 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
RAD51BRAD51 paralog B. (270 aa)
CECR2CECR2 histone acetyl-lysine reader. (1449 aa)
DSCC1Uncharacterized protein. (388 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (832 aa)
ENSCHIP00000012571Uncharacterized protein. (386 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1212 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (893 aa)
POLQDNA polymerase theta. (2587 aa)
SMARCA5Uncharacterized protein. (1052 aa)
ATRXATRX chromatin remodeler. (2105 aa)
MPHOSPH9M-phase phosphoprotein 9. (1136 aa)
PMS1PMS1 homolog 1, mismatch repair system component. (932 aa)
HELQHelicase, POLQ like. (1115 aa)
RAD54LRAD54 like. (749 aa)
MSH5DNA_MISMATCH_REPAIR_2 domain-containing protein. (821 aa)
RFC1Replication factor C subunit 1. (1143 aa)
MCM2DNA helicase; Belongs to the MCM family. (1061 aa)
RAD51DDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (338 aa)
DQX1DEAQ-box RNA dependent ATPase 1. (719 aa)
CHD4Uncharacterized protein. (1905 aa)
RFC4Replication factor C subunit 4. (364 aa)
ERCC6L2Uncharacterized protein. (1558 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2836 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (341 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1609 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (724 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (946 aa)
XRCC5X-ray repair cross complementing 5. (736 aa)
CHD2Uncharacterized protein. (1823 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
ENSCHIP00000027862WD_REPEATS_REGION domain-containing protein. (404 aa)
ASCC3Activating signal cointegrator 1 complex subunit 3. (2201 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (347 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (395 aa)
HLTFHelicase like transcription factor. (1011 aa)
XRCC2X-ray repair cross complementing 2. (280 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (649 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (471 aa)
DDX3XUncharacterized protein; Belongs to the DEAD box helicase family. (661 aa)
RAD17RAD17 checkpoint clamp loader component. (709 aa)
TTF2Transcription termination factor 2. (1205 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
RSF1Remodeling and spacing factor 1. (1429 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (930 aa)
CHD1Chromodomain helicase DNA binding protein 1. (1711 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1070 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1572 aa)
HELBDNA helicase B. (1077 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1119 aa)
MSH4MutS homolog 4. (930 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2583 aa)
ENSCHIP00000000025Uncharacterized protein. (552 aa)
SUPV3L1Suv3 like RNA helicase. (787 aa)
NAV2Neuron navigator 2. (2452 aa)
RBBP4-2WD_REPEATS_REGION domain-containing protein. (425 aa)
ENSCHIP00000002436Uncharacterized protein. (175 aa)
RAD50Zinc-hook domain-containing protein. (1332 aa)
ENSCHIP00000003676RECA_2 domain-containing protein. (278 aa)
FSBPUncharacterized protein. (909 aa)
ENSCHIP00000004265Uncharacterized protein. (393 aa)
SUB1SUB1 regulator of transcription. (127 aa)
SHPRHSNF2 histone linker PHD RING helicase. (1685 aa)
RAD54L2RAD54 like 2. (1467 aa)
CHTF18Chromosome transmission fidelity factor 18. (948 aa)
RFC2Replication factor C subunit 2. (352 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa)
MLH3MutL homolog 3. (1463 aa)
SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1114 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1481 aa)
ERCC6LERCC excision repair 6 like, spindle assembly checkpoint helicase. (1242 aa)
INO80INO80 complex ATPase subunit. (1566 aa)
BLMBLM RecQ like helicase. (1429 aa)
TWNKTwinkle mtDNA helicase. (684 aa)
UPF1UPF1 RNA helicase and ATPase. (1126 aa)
DDX1DEAD-box helicase 1. (740 aa)
ENSCHIP00000007747DUF4550 domain-containing protein. (556 aa)
RECQL4RecQ like helicase 4. (1176 aa)
ENSCHIP00000007823Uncharacterized protein. (663 aa)
SMC3Structural maintenance of chromosomes protein. (1231 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
IGHMBP2Immunoglobulin mu DNA binding protein 2. (987 aa)
EP400E1A binding protein p400. (3022 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2993 aa)
SRCAPUncharacterized protein. (3241 aa)
MLH1MutL homolog 1. (758 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1538 aa)
RFC3Replication factor C subunit 3. (356 aa)
BPTFBromodomain PHD finger transcription factor. (3013 aa)
XRCC6X-ray repair cross complementing 6. (607 aa)
C17orf64Chromosome 17 open reading frame 64. (234 aa)
SMARCAD1Uncharacterized protein. (1028 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
DNA2DNA replication helicase/nuclease 2. (1062 aa)
DHX9DExH-box helicase 9. (1271 aa)
ENSCHIP00000019703Helicase ATP-binding domain-containing protein. (459 aa)
ENSCHIP00000019473Uncharacterized protein. (248 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1137 aa)
MCM4DNA helicase; Belongs to the MCM family. (851 aa)
CHD6Chromodomain helicase DNA binding protein 6. (2720 aa)
SMC5AAA_23 domain-containing protein. (1104 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
DHX36DEAH-box helicase 36. (1010 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (887 aa)
ATAD5ATPase family AAA domain containing 5. (1894 aa)
CHD3Chromodomain helicase DNA binding protein 3. (1979 aa)
LOC108637664Uncharacterized protein. (1041 aa)
TM4SF19Uncharacterized protein. (202 aa)
FBH1F-box DNA helicase 1. (1048 aa)
RBBP4WD_REPEATS_REGION domain-containing protein. (426 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1217 aa)
G3BP1G3BP stress granule assembly factor 1. (465 aa)
DDX11DEAD/H-box helicase 11. (928 aa)
CEP41Centrosomal protein 41. (368 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1606 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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