(45 nodes) Nucleoside metabolic process network (Capra hircus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	UPB1	Beta-ureidopropionase 1. (325 aa)
	UPP1	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (312 aa)
	MTAP	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (283 aa)
	DNPH1	2'-deoxynucleoside 5'-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. (198 aa)
	GDA	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (454 aa)
	PGM2	Phosphoglucomutase 2. (629 aa)
	URAD	OHCU_decarbox domain-containing protein. (170 aa)
	HPRT1	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
	DPYD	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1033 aa)
	NT5C2	5'-nucleotidase, cytosolic II. (570 aa)
	ACPP	Acid phosphatase, prostate; Belongs to the histidine acid phosphatase family. (387 aa)
	ADA2	Adenosine deaminase 2. (513 aa)
	TK1	Thymidine kinase. (238 aa)
	XDH	FAD-binding PCMH-type domain-containing protein. (1331 aa)
	UPP2	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (330 aa)
	APRT	Adenine phosphoribosyltransferase. (180 aa)
	ENSCHIP00000020344	Uncharacterized protein. (108 aa)
	PRTFDC1	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (225 aa)
	MACROD1	Mono-ADP ribosylhydrolase 1. (325 aa)
	NT5DC4	5'-nucleotidase domain containing 4. (374 aa)
	ENSCHIP00000026638	Uncharacterized protein. (190 aa)
	CDADC1	Cytidine and dCMP deaminase domain containing 1. (499 aa)
	DTYMK	Deoxythymidylate kinase. (212 aa)
	NUDT1	Nudix hydrolase 1. (167 aa)
	OARD1	O-acyl-ADP-ribose deacylase 1. (152 aa)
	DGUOK	Deoxyguanosine kinase. (277 aa)
	LOC102168228	Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family. (309 aa)
	APOBEC2	Apolipoprotein B mRNA editing enzyme catalytic subunit 2. (224 aa)
	GNMT	Glycine N-methyltransferase. (295 aa)
	LOC102184324	Uncharacterized protein. (374 aa)
	LOC102177447	Uncharacterized protein. (617 aa)
	NT5C1A	5'-nucleotidase, cytosolic IA. (365 aa)
	ADA	Adenosine deaminase. (400 aa)
	DERA	Deoxyribose-phosphate aldolase. (351 aa)
	CDA	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
	ADK	Adenosine kinase. (362 aa)
	ADAL	Adenosine deaminase like. (352 aa)
	LOC102176691	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
	NT5E	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa)
	APOBEC1	Apolipoprotein B mRNA editing enzyme catalytic subunit 1. (241 aa)
	PNP	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
	MACROD2	Uncharacterized protein. (222 aa)
	AICDA	Activation induced cytidine deaminase. (199 aa)
	LOC106502146	CMP/dCMP-type deaminase domain-containing protein. (213 aa)
	ENPP4	Ectonucleotide pyrophosphatase/phosphodiesterase 4. (466 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADA	ADA2	ENSCHIP00000033539	ENSCHIP00000016618	Adenosine deaminase.	Adenosine deaminase 2.	0.940
ADA	ADK	ENSCHIP00000033539	ENSCHIP00000000140	Adenosine deaminase.	Adenosine kinase.	0.993
ADA	APOBEC2	ENSCHIP00000033539	ENSCHIP00000032325	Adenosine deaminase.	Apolipoprotein B mRNA editing enzyme catalytic subunit 2.	0.471
ADA	APRT	ENSCHIP00000033539	ENSCHIP00000019564	Adenosine deaminase.	Adenine phosphoribosyltransferase.	0.866
ADA	CDA	ENSCHIP00000033539	ENSCHIP00000033674	Adenosine deaminase.	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	0.521
ADA	ENSCHIP00000026638	ENSCHIP00000033539	ENSCHIP00000026638	Adenosine deaminase.	Uncharacterized protein.	0.439
ADA	GDA	ENSCHIP00000033539	ENSCHIP00000014215	Adenosine deaminase.	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.	0.674
ADA	HPRT1	ENSCHIP00000033539	ENSCHIP00000014909	Adenosine deaminase.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.499
ADA	LOC102168228	ENSCHIP00000033539	ENSCHIP00000031057	Adenosine deaminase.	Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family.	0.562
ADA	LOC102176691	ENSCHIP00000033539	ENSCHIP00000006635	Adenosine deaminase.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.988
ADA	MTAP	ENSCHIP00000033539	ENSCHIP00000013202	Adenosine deaminase.	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	0.521
ADA	NT5C1A	ENSCHIP00000033539	ENSCHIP00000033183	Adenosine deaminase.	5'-nucleotidase, cytosolic IA.	0.902
ADA	NT5C2	ENSCHIP00000033539	ENSCHIP00000015676	Adenosine deaminase.	5'-nucleotidase, cytosolic II.	0.912
ADA	NT5DC4	ENSCHIP00000033539	ENSCHIP00000024131	Adenosine deaminase.	5'-nucleotidase domain containing 4.	0.616
ADA	NT5E	ENSCHIP00000033539	ENSCHIP00000007021	Adenosine deaminase.	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family.	0.968
ADA	PNP	ENSCHIP00000033539	ENSCHIP00000008961	Adenosine deaminase.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.988
ADA	PRTFDC1	ENSCHIP00000033539	ENSCHIP00000020785	Adenosine deaminase.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.493
ADA	UPP1	ENSCHIP00000033539	ENSCHIP00000013138	Adenosine deaminase.	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.	0.488
ADA	UPP2	ENSCHIP00000033539	ENSCHIP00000018437	Adenosine deaminase.	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.	0.407
ADA	XDH	ENSCHIP00000033539	ENSCHIP00000017631	Adenosine deaminase.	FAD-binding PCMH-type domain-containing protein.	0.408