STRINGSTRING
ADA ADA GART GART PRTFDC1 PRTFDC1 ADSS2 ADSS2 ENSCHIP00000022067 ENSCHIP00000022067 ENSCHIP00000023015 ENSCHIP00000023015 CAD CAD GMPS GMPS ENSCHIP00000026638 ENSCHIP00000026638 RFK RFK UCK2 UCK2 ENSCHIP00000028583 ENSCHIP00000028583 ENSCHIP00000028599 ENSCHIP00000028599 DGUOK DGUOK ATIC ATIC UMPS UMPS TK2 TK2 APRT APRT ADSS1 ADSS1 ENSCHIP00000018720 ENSCHIP00000018720 IMPDH1 IMPDH1 LOC102173923 LOC102173923 UPP2 UPP2 TK1 TK1 ENSCHIP00000016608 ENSCHIP00000016608 UPRT UPRT ADSL ADSL AMPD1 AMPD1 HPRT1 HPRT1 UCKL1 UCKL1 ENSCHIP00000013297 ENSCHIP00000013297 UPP1 UPP1 PPAT PPAT AMPD3 AMPD3 AMPD2 AMPD2 NUDT2 NUDT2 LOC102182773 LOC102182773 ENTPD8 ENTPD8 IMPDH2 IMPDH2 UCK1 UCK1 DCTD DCTD DUT DUT PFAS PFAS LOC102184716 LOC102184716 PRPS1L1 PRPS1L1 ENSCHIP00000003926 ENSCHIP00000003926 LOC102169764 LOC102169764 ENSCHIP00000002983 ENSCHIP00000002983 PRPS2 PRPS2 DHODH DHODH ADK ADK TYMS TYMS DCK DCK ENSCHIP00000030793 ENSCHIP00000030793
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADAAdenosine deaminase. (400 aa)
GARTTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa)
PRTFDC1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (225 aa)
ADSS2Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
ENSCHIP00000022067Lyase_1 domain-containing protein. (447 aa)
ENSCHIP00000023015dUTPase domain-containing protein. (121 aa)
CADCarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2242 aa)
GMPSGuanine monophosphate synthase. (693 aa)
ENSCHIP00000026638Uncharacterized protein. (190 aa)
RFKRiboflavin kinase. (155 aa)
UCK2Uridine-cytidine kinase; Belongs to the uridine kinase family. (261 aa)
ENSCHIP00000028583Pribosyltran_N domain-containing protein. (279 aa)
ENSCHIP00000028599Pribosyltran_N domain-containing protein. (301 aa)
DGUOKDeoxyguanosine kinase. (277 aa)
ATIC5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (592 aa)
UMPSUridine monophosphate synthetase. (507 aa)
TK2Thymidine kinase 2. (275 aa)
APRTAdenine phosphoribosyltransferase. (180 aa)
ADSS1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (457 aa)
ENSCHIP00000018720dUTPase domain-containing protein. (199 aa)
IMPDH1Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (571 aa)
LOC102173923Pribosyltran_N domain-containing protein. (318 aa)
UPP2Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (330 aa)
TK1Thymidine kinase. (238 aa)
ENSCHIP00000016608dUTPase domain-containing protein. (181 aa)
UPRTUracil phosphoribosyltransferase homolog. (306 aa)
ADSLAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (490 aa)
AMPD1AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (731 aa)
HPRT1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
UCKL1Uridine-cytidine kinase; Belongs to the uridine kinase family. (552 aa)
ENSCHIP00000013297Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (219 aa)
UPP1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (312 aa)
PPATAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (514 aa)
AMPD3AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (786 aa)
AMPD2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (817 aa)
NUDT2Nudix hydrolase 2; Belongs to the Nudix hydrolase family. (147 aa)
LOC102182773AIRC domain-containing protein. (425 aa)
ENTPD8Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (495 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
UCK1Uridine-cytidine kinase; Belongs to the uridine kinase family. (277 aa)
DCTDDeoxycytidylate deaminase. (178 aa)
DUTdUTPase domain-containing protein. (242 aa)
PFASPhosphoribosylformylglycinamidine synthase. (1372 aa)
LOC102184716Pribosyltran_N domain-containing protein. (318 aa)
PRPS1L1Phosphoribosyl pyrophosphate synthetase 1 like 1. (313 aa)
ENSCHIP00000003926Pribosyltran_N domain-containing protein. (318 aa)
LOC102169764AIRC domain-containing protein. (420 aa)
ENSCHIP00000002983Glutamine amidotransferase type-2 domain-containing protein. (272 aa)
PRPS2Phosphoribosyl pyrophosphate synthetase 2. (318 aa)
DHODHDihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (395 aa)
ADKAdenosine kinase. (362 aa)
TYMSThymidylate synthetase. (355 aa)
DCKDeoxycytidine kinase. (260 aa)
ENSCHIP00000030793Amidophosphoribosyltransferase. (439 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.