STRINGSTRING
DLX6 DLX6 PLEC PLEC HES5 HES5 CUL4B CUL4B ABL1 ABL1 CNTNAP1 CNTNAP1 SOX9 SOX9 S100B S100B MAP2K1 MAP2K1 NOTCH1 NOTCH1 DLL1 DLL1 NR2E1 NR2E1 EIF2B2 EIF2B2 HDAC1 HDAC1 VIM VIM DUSP10 DUSP10 STAT3 STAT3 METRNL METRNL DNER DNER SOX10 SOX10 MTOR MTOR OLIG1 OLIG1 GPR157 GPR157 SIRT2 SIRT2 MT3 MT3 PTPN11 PTPN11 NCMAP NCMAP NAB2 NAB2 PRDM8 PRDM8 EGR2 EGR2 CDH2 CDH2 TLR4 TLR4 GAP43 GAP43 PHGDH PHGDH FGF2 FGF2 HES1 HES1 GCM1 GCM1 CNTN2 CNTN2 WASF3 WASF3 PHOX2B PHOX2B ILK ILK PTPRZ1 PTPRZ1 B4GALT5 B4GALT5 SOX8 SOX8 S100A9 S100A9 IFNG IFNG CNTN1 CNTN1 C5AR1 C5AR1 RELN RELN MAPK3 MAPK3 NDRG1 NDRG1 DAG1 DAG1 SH3TC2 SH3TC2 EIF2B3 EIF2B3 LAMB2 LAMB2 EIF2B1 EIF2B1 GLI3 GLI3 AKT2 AKT2 SOD1 SOD1 VTN VTN DLX1 DLX1 MYOC MYOC ERBB3 ERBB3 RHOA RHOA AGER AGER ENSCHIP00000011371 ENSCHIP00000011371 SOX4 SOX4 ASCL1 ASCL1 ENSCHIP00000010693 ENSCHIP00000010693 MMP24 MMP24 TPPP TPPP SOX13 SOX13 BMP2 BMP2 FGF10 FGF10 ENSCHIP00000009957 ENSCHIP00000009957 NFIB NFIB FA2H FA2H TGFB1 TGFB1 PICK1 PICK1 EMX1 EMX1 NRROS NRROS NF1 NF1 CNTF CNTF MAG MAG GPR37L1 GPR37L1 ARHGEF10 ARHGEF10 SH3TC1 SH3TC1 POU3F2 POU3F2 TREM2 TREM2 POU3F1 POU3F1 TSPAN2 TSPAN2 OLIG2 OLIG2 CNP CNP TRPC4 TRPC4 ITGB4 ITGB4 LGI4 LGI4 PPP3R1 PPP3R1 MYRF MYRF VAX1 VAX1 NKX6-2 NKX6-2 KCNJ10 KCNJ10 NEUROD4 NEUROD4 B4GALT6 B4GALT6 MAPK1 MAPK1 ENSCHIP00000000097 ENSCHIP00000000097 NCSTN NCSTN METRN METRN TTC21B TTC21B TENM4 TENM4 MED12 MED12 PRX PRX S100A8 S100A8 KRAS KRAS APP APP SUZ12 SUZ12 EIF2B5 EIF2B5 GBA GBA ERBB2 ERBB2 CDK5 CDK5 LAMC3 LAMC3 CTNNB1 CTNNB1 PLP1 PLP1 ASPA ASPA EIF2B4 EIF2B4 LEF1 LEF1 PSEN1 PSEN1 NKX2-2 NKX2-2 FGF5 FGF5 DLX2 DLX2 C1QA C1QA METTL14 METTL14 NKX2-1 NKX2-1 NKX6-1 NKX6-1 GFAP GFAP TAL1 TAL1 MPP5 MPP5 SHH SHH CRB1 CRB1 PAX6 PAX6 AKT1 AKT1 MXRA8 MXRA8 SMO SMO NTRK2 NTRK2 ERCC2 ERCC2 PLPP3 PLPP3 ADGRG6 ADGRG6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLX6Distal-less homeobox 6. (230 aa)
PLECPlectin. (4150 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
CUL4BCullin 4B; Belongs to the cullin family. (1027 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
CNTNAP1Contactin associated protein 1. (1396 aa)
SOX9SRY-box transcription factor 9. (525 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (397 aa)
NOTCH1Notch receptor 1. (2508 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
EIF2B2Eukaryotic translation initiation factor 2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (351 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (464 aa)
VIMVimentin; Belongs to the intermediate filament family. (471 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
METRNLMeteorin like, glial cell differentiation regulator. (309 aa)
DNERDelta/notch like EGF repeat containing. (728 aa)
SOX10SRY-box transcription factor 10. (469 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
OLIG1Oligodendrocyte transcription factor 1. (259 aa)
GPR157G protein-coupled receptor 157. (335 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (390 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
NCMAPNon-compact myelin associated protein. (102 aa)
NAB2NGFI-A binding protein 2. (525 aa)
PRDM8PR/SET domain 8. (683 aa)
EGR2Early growth response 2. (472 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
GAP43Growth associated protein 43. (238 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
GCM1Glial cells missing transcription factor 1. (427 aa)
CNTN2Contactin 2. (1046 aa)
WASF3WASP family member 3. (501 aa)
PHOX2BPaired like homeobox 2B. (315 aa)
ILKIntegrin linked kinase. (452 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2323 aa)
B4GALT5Beta-1,4-galactosyltransferase 5. (388 aa)
SOX8SRY-box transcription factor 8. (534 aa)
S100A9EF-hand domain-containing protein; Belongs to the S-100 family. (151 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
CNTN1Contactin 1. (1018 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (352 aa)
RELNReelin. (3469 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
NDRG1N-myc downstream regulated 1. (384 aa)
DAG1Dystroglycan 1. (895 aa)
SH3TC2SH3 domain and tetratricopeptide repeats 2. (1289 aa)
EIF2B3Eukaryotic translation initiation factor 2B subunit gamma. (461 aa)
LAMB2Laminin subunit beta 2. (1802 aa)
EIF2B1Uncharacterized protein; Belongs to the eIF-2B alpha/beta/delta subunits family. (305 aa)
GLI3GLI family zinc finger 3. (1614 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
VTNSMB domain-containing protein. (475 aa)
DLX1Distal-less homeobox 1. (255 aa)
MYOCMyocilin. (490 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1344 aa)
RHOARas-like protein family member A. (193 aa)
AGERAdvanced glycosylation end-product specific receptor. (416 aa)
ENSCHIP00000011371Uncharacterized protein. (193 aa)
SOX4SRY-box transcription factor 4. (504 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (219 aa)
ENSCHIP00000010693Uncharacterized protein; Belongs to the eIF-2B alpha/beta/delta subunits family. (216 aa)
MMP24Matrix metallopeptidase 24. (601 aa)
TPPPTubulin polymerization promoting protein. (221 aa)
SOX13SRY-box transcription factor 13. (592 aa)
BMP2TGF_BETA_2 domain-containing protein. (381 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
ENSCHIP00000009957Calponin-homology (CH) domain-containing protein. (123 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PICK1Protein interacting with PRKCA 1. (417 aa)
EMX1Empty spiracles homeobox 1. (288 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
NF1Neurofibromin 1. (2848 aa)
CNTFCiliary neurotrophic factor. (199 aa)
MAGMyelin associated glycoprotein. (626 aa)
GPR37L1G protein-coupled receptor 37 like 1. (478 aa)
ARHGEF10Rho guanine nucleotide exchange factor 10. (1328 aa)
SH3TC1SH3 domain and tetratricopeptide repeats 1. (1320 aa)
POU3F2POU domain protein. (438 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
POU3F1POU domain protein. (451 aa)
TSPAN2Tetraspanin. (221 aa)
OLIG2Oligodendrocyte transcription factor 2. (329 aa)
CNP2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family. (421 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (979 aa)
ITGB4Integrin beta. (1850 aa)
LGI4Leucine rich repeat LGI family member 4. (538 aa)
PPP3R1Uncharacterized protein. (170 aa)
MYRFMyelin regulatory factor. (1147 aa)
VAX1Ventral anterior homeobox 1. (334 aa)
NKX6-2NK6 homeobox 2. (286 aa)
KCNJ10Potassium voltage-gated channel subfamily J member 10. (379 aa)
NEUROD4Neurogenic differentiation factor. (334 aa)
B4GALT6Beta-1,4-galactosyltransferase 6. (387 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
ENSCHIP00000000097Med12-PQL domain-containing protein. (315 aa)
NCSTNNicastrin. (709 aa)
METRNMeteorin, glial cell differentiation regulator. (273 aa)
TTC21BTetratricopeptide repeat domain 21B. (1326 aa)
TENM4Teneurin transmembrane protein 4. (2855 aa)
MED12Med12 domain-containing protein. (2040 aa)
PRXPeriaxin. (1401 aa)
S100A8S100 calcium binding protein A8; Belongs to the S-100 family. (89 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
APPAmyloid beta precursor protein. (770 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (739 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (724 aa)
GBAGlucosylceramidase. (536 aa)
ERBB2Receptor protein-tyrosine kinase. (1250 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
LAMC3Laminin subunit gamma 3. (1575 aa)
CTNNB1Catenin beta 1. (781 aa)
PLP1Proteolipid protein 1. (277 aa)
ASPAAspartoacylase. (313 aa)
EIF2B4Eukaryotic translation initiation factor 2B subunit delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (539 aa)
LEF1HMG box domain-containing protein. (430 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (475 aa)
NKX2-2NK2 homeobox 2. (273 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
DLX2Distal-less homeobox 2. (328 aa)
C1QAComplement C1q A chain. (313 aa)
METTL14Methyltransferase like 14; Belongs to the MT-A70-like family. (456 aa)
NKX2-1NK2 homeobox 1. (370 aa)
NKX6-1NK6 homeobox 1. (367 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (428 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (328 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
CRB1Crumbs cell polarity complex component 1. (1409 aa)
PAX6Paired box 6. (486 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
MXRA8Matrix remodeling associated 8. (447 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
NTRK2Tyrosine-protein kinase receptor. (837 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
PLPP3acidPPc domain-containing protein. (312 aa)
ADGRG6Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family. (1250 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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