(20 nodes) Regulation of cell fate commitment network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SOSTDC1	Sclerostin domain containing 1. (206 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	NKX6-2	NK6 homeobox 2. (286 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (256 aa)
	IL23A	Interleukin 23 subunit alpha. (190 aa)
	NANOG	Homeobox domain-containing protein. (300 aa)
	SFRP2	Secreted frizzled related protein 2. (294 aa)
	AR	Androgen receptor. (891 aa)
	GLIS1	GLIS family zinc finger 1. (796 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	TBX21	T-box transcription factor 21. (533 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
	SPDEF	SAM pointed domain containing ETS transcription factor. (330 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa)
	LOXL3	Lysyl oxidase like 3. (752 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	SOX17	SRY-box transcription factor 17. (410 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	SPDEF	ENSCHIP00000024342	ENSCHIP00000017084	Androgen receptor.	SAM pointed domain containing ETS transcription factor.	0.403
BMP4	BMPR1A	ENSCHIP00000023678	ENSCHIP00000000640	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.999
BMP4	FGF2	ENSCHIP00000023678	ENSCHIP00000019134	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.872
BMP4	NANOG	ENSCHIP00000023678	ENSCHIP00000009313	Bone morphogenetic protein 4.	Homeobox domain-containing protein.	0.887
BMP4	SFRP2	ENSCHIP00000023678	ENSCHIP00000026721	Bone morphogenetic protein 4.	Secreted frizzled related protein 2.	0.494
BMP4	SOX17	ENSCHIP00000023678	ENSCHIP00000023300	Bone morphogenetic protein 4.	SRY-box transcription factor 17.	0.876
BMP4	WNT11	ENSCHIP00000023678	ENSCHIP00000024696	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.618
BMP4	WNT3A	ENSCHIP00000023678	ENSCHIP00000015590	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.874
BMP4	WNT5A	ENSCHIP00000023678	ENSCHIP00000015533	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.731
BMPR1A	BMP4	ENSCHIP00000000640	ENSCHIP00000023678	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.999
BMPR1A	SFRP2	ENSCHIP00000000640	ENSCHIP00000026721	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Secreted frizzled related protein 2.	0.405
BMPR1A	WNT3A	ENSCHIP00000000640	ENSCHIP00000015590	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.433
BMPR1A	WNT5A	ENSCHIP00000000640	ENSCHIP00000015533	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.432
FGF2	BMP4	ENSCHIP00000019134	ENSCHIP00000023678	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.872
FGF2	NANOG	ENSCHIP00000019134	ENSCHIP00000009313	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox domain-containing protein.	0.844
FGF2	SOX17	ENSCHIP00000019134	ENSCHIP00000023300	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	SRY-box transcription factor 17.	0.651
FGF2	WNT3A	ENSCHIP00000019134	ENSCHIP00000015590	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.777
FGF2	WNT5A	ENSCHIP00000019134	ENSCHIP00000015533	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.476
FZD7	SFRP2	ENSCHIP00000032272	ENSCHIP00000026721	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled related protein 2.	0.738
FZD7	WNT11	ENSCHIP00000032272	ENSCHIP00000024696	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.985