71 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SPIDR	Scaffold protein involved in DNA repair. (916 aa)
	ENSCHIP00000031621	Uncharacterized protein. (159 aa)
	SIRT6	Sirtuin 6. (335 aa)
	ENSCHIP00000031435	Uncharacterized protein. (77 aa)
	CHEK1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
	RUVBL2	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (471 aa)
	EPC2	Enhancer of polycomb homolog. (807 aa)
	SHLD2	Shieldin complex subunit 2. (918 aa)
	SMCHD1	Structural maintenance of chromosomes flexible hinge domain containing 1. (1987 aa)
	MEAF6	MYST/Esa1 associated factor 6. (201 aa)
	MBTD1	Mbt domain containing 1. (628 aa)
	RAD51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
	HELB	DNA helicase B. (1077 aa)
	ENSCHIP00000001690	Uncharacterized protein. (204 aa)
	FUS	FUS RNA binding protein. (522 aa)
	FIGNL1	Fidgetin like 1; Belongs to the AAA ATPase family. (677 aa)
	EPC1	Enhancer of polycomb homolog. (842 aa)
	PPP4R2	Protein phosphatase 4 regulatory subunit 2. (412 aa)
	MORF4L1	Mortality factor 4 like 1. (363 aa)
	KDM1A	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (873 aa)
	WDR48	WD repeat domain 48. (678 aa)
	ING3	Inhibitor of growth protein. (418 aa)
	RECQL5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa)
	ERCC6	ERCC excision repair 6, chromatin remodeling factor. (1481 aa)
	TP53BP1	Tumor protein p53 binding protein 1. (1966 aa)
	TIMELESS	Timeless circadian regulator. (1206 aa)
	ARID2	AT-rich interaction domain 2. (1835 aa)
	MAD2L2	Mitotic arrest deficient 2 like 2. (195 aa)
	LOC102188481	Uncharacterized protein. (379 aa)
	EP400	E1A binding protein p400. (3022 aa)
	RBBP8	RB binding protein 8, endonuclease. (889 aa)
	ACTB	Uncharacterized protein. (375 aa)
	POLQ	DNA polymerase theta. (2587 aa)
	RTEL1	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1212 aa)
	RAD51AP1	RAD51 associated protein 1. (326 aa)
	YEATS4	YEATS domain containing 4. (227 aa)
	MRGBP	Uncharacterized protein. (204 aa)
	VPS72	Vacuolar protein sorting 72 homolog. (364 aa)
	SHLD1	Shieldin complex subunit 1. (206 aa)
	UBQLN4	Ubiquilin 4. (601 aa)
	MMS19	MMS19 homolog, cytosolic iron-sulfur assembly component. (1030 aa)
	PIAS4	Protein inhibitor of activated STAT 4. (513 aa)
	KAT5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
	FANCB	Uncharacterized protein. (447 aa)
	WRAP53	WD repeat containing antisense to TP53. (540 aa)
	ENSCHIP00000015471	MRG domain-containing protein. (231 aa)
	FBH1	F-box DNA helicase 1. (1048 aa)
	ACTL6A	Actin like 6A; Belongs to the actin family. (458 aa)
	MRNIP	MRN complex interacting protein. (361 aa)
	PARP1	Poly [ADP-ribose] polymerase. (1020 aa)
	MAGEF1	MAGE family member F1. (299 aa)
	CGAS	Cyclic GMP-AMP synthase. (511 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2556 aa)
	HDGFL2	HDGF like 2. (658 aa)
	RUVBL1	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
	MORF4L2	Mortality factor 4 like 2. (287 aa)
	HELQ	Helicase, POLQ like. (1115 aa)
	POGZ	Pogo transposable element derived with ZNF domain. (1413 aa)
	RIF1	Replication timing regulatory factor 1. (2486 aa)
	KHDC3L	MOEP19 domain-containing protein. (325 aa)
	TERF2IP	Uncharacterized protein. (400 aa)
	BRD8	Bromodomain containing 8. (1216 aa)
	KLHL15	Kelch like family member 15. (604 aa)
	RMI2	Uncharacterized protein. (161 aa)
	RADX	RPA1 related single stranded DNA binding protein, X-linked. (764 aa)
	DMAP1	DNA methyltransferase 1 associated protein 1. (468 aa)
	PPP4C	Serine/threonine-protein phosphatase. (307 aa)
	ZNF365	Zinc finger protein 365. (406 aa)
	OOEP	Oocyte expressed protein. (140 aa)
	WAS	WASP actin nucleation promoting factor. (536 aa)
	PARPBP	PARP1 binding protein. (580 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ACTL6A	ENSCHIP00000011080	ENSCHIP00000016944	Uncharacterized protein.	Actin like 6A; Belongs to the actin family.	0.942
ACTB	ARID2	ENSCHIP00000011080	ENSCHIP00000007348	Uncharacterized protein.	AT-rich interaction domain 2.	0.854
ACTB	BRD8	ENSCHIP00000011080	ENSCHIP00000024027	Uncharacterized protein.	Bromodomain containing 8.	0.473
ACTB	CGAS	ENSCHIP00000011080	ENSCHIP00000019358	Uncharacterized protein.	Cyclic GMP-AMP synthase.	0.581
ACTB	CHEK1	ENSCHIP00000011080	ENSCHIP00000030673	Uncharacterized protein.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.456
ACTB	DMAP1	ENSCHIP00000011080	ENSCHIP00000025187	Uncharacterized protein.	DNA methyltransferase 1 associated protein 1.	0.675
ACTB	ENSCHIP00000001690	ENSCHIP00000011080	ENSCHIP00000001690	Uncharacterized protein.	Uncharacterized protein.	0.517
ACTB	ENSCHIP00000015471	ENSCHIP00000011080	ENSCHIP00000015471	Uncharacterized protein.	MRG domain-containing protein.	0.483
ACTB	EP400	ENSCHIP00000011080	ENSCHIP00000008609	Uncharacterized protein.	E1A binding protein p400.	0.612
ACTB	EPC1	ENSCHIP00000011080	ENSCHIP00000002518	Uncharacterized protein.	Enhancer of polycomb homolog.	0.599
ACTB	EPC2	ENSCHIP00000011080	ENSCHIP00000029051	Uncharacterized protein.	Enhancer of polycomb homolog.	0.648
ACTB	FUS	ENSCHIP00000011080	ENSCHIP00000002026	Uncharacterized protein.	FUS RNA binding protein.	0.558
ACTB	ING3	ENSCHIP00000011080	ENSCHIP00000005655	Uncharacterized protein.	Inhibitor of growth protein.	0.534
ACTB	KAT5	ENSCHIP00000011080	ENSCHIP00000014439	Uncharacterized protein.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.569
ACTB	MEAF6	ENSCHIP00000011080	ENSCHIP00000001496	Uncharacterized protein.	MYST/Esa1 associated factor 6.	0.613
ACTB	MORF4L1	ENSCHIP00000011080	ENSCHIP00000004830	Uncharacterized protein.	Mortality factor 4 like 1.	0.483
ACTB	MORF4L2	ENSCHIP00000011080	ENSCHIP00000021932	Uncharacterized protein.	Mortality factor 4 like 2.	0.496
ACTB	MRGBP	ENSCHIP00000011080	ENSCHIP00000013002	Uncharacterized protein.	Uncharacterized protein.	0.517
ACTB	PARP1	ENSCHIP00000011080	ENSCHIP00000019007	Uncharacterized protein.	Poly [ADP-ribose] polymerase.	0.783
ACTB	PPP4C	ENSCHIP00000011080	ENSCHIP00000025595	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.411