(88 nodes) Epithelial cell migration network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NR4A1	Nuclear receptor subfamily 4 group A member 1. (623 aa)
	GREM1	Gremlin. (184 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1390 aa)
	LTB4R2	Leukotriene B4 receptor 2. (358 aa)
	FAP	Fibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
	NANOS1	Nanos C2HC-type zinc finger 1; Belongs to the nanos family. (292 aa)
	LOC108633235	Galectin. (333 aa)
	IRS2	Insulin receptor substrate 2. (1465 aa)
	ARSB	Arylsulfatase B. (531 aa)
	CCBE1	Collagen and calcium binding EGF domains 1. (407 aa)
	MMRN2	Multimerin 2. (937 aa)
	ARSI	Arylsulfatase family member I. (574 aa)
	PXN	Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (581 aa)
	ARSJ	Arylsulfatase family member J. (599 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	CDH13	Cadherin 13. (663 aa)
	KRT16	Keratin 16; Belongs to the intermediate filament family. (445 aa)
	EMP2	Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
	SRF	Serum response factor. (509 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (539 aa)
	S100A2	Protein S100; Belongs to the S-100 family. (98 aa)
	TESK1	Testis associated actin remodelling kinase 1. (630 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1193 aa)
	ENSCHIP00000011371	Uncharacterized protein. (193 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (441 aa)
	RHOA	Ras-like protein family member A. (193 aa)
	SNAI1	Snail family transcriptional repressor 1. (264 aa)
	DAAM2	Dishevelled associated activator of morphogenesis 2. (1087 aa)
	LOXL2	Lysyl oxidase like 2. (791 aa)
	CDH5	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
	PIK3R3	Uncharacterized protein. (461 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
	GIPC1	GIPC PDZ domain containing family member 1. (333 aa)
	CXCL13	C-X-C motif chemokine. (109 aa)
	ANLN	Anillin actin binding protein. (1148 aa)
	ADGRA2	Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1335 aa)
	LRG1	Leucine rich alpha-2-glycoprotein 1. (353 aa)
	FERMT1	Fermitin family member 1. (679 aa)
	ROBO1	Uncharacterized protein. (1474 aa)
	KANK2	KN motif and ankyrin repeat domains 2. (858 aa)
	CORO1B	Coronin; Belongs to the WD repeat coronin family. (488 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
	KANK1	KN motif and ankyrin repeat domains 1. (1357 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	S100Z	S100 calcium binding protein Z; Belongs to the S-100 family. (85 aa)
	PKN3	Protein kinase N3. (889 aa)
	GIPC3	GIPC PDZ domain containing family member 3. (318 aa)
	WDPCP	WD repeat containing planar cell polarity effector. (676 aa)
	PRKX	Uncharacterized protein; Belongs to the protein kinase superfamily. (347 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	FSTL1	Follistatin like 1. (312 aa)
	LPXN	Leupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (390 aa)
	MYH9	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1986 aa)
	PLEKHG5	Pleckstrin homology and RhoGEF domain containing G5. (1164 aa)
	LOC102175469	Galectin. (325 aa)
	PAXIP1	PAX interacting protein 1. (1006 aa)
	EFNB2	Ephrin B2; Belongs to the ephrin family. (335 aa)
	VSTM4	V-set and transmembrane domain containing 4. (321 aa)
	CLN3	Battenin. (442 aa)
	DPP4	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (767 aa)
	STARD13	StAR related lipid transfer domain containing 13. (1121 aa)
	PROX1	Prospero homeobox 1. (734 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (461 aa)
	EPHB4	EPH receptor B4. (993 aa)
	ABL1	Tyrosine-protein kinase. (1151 aa)
	RAB13	Uncharacterized protein. (203 aa)
	KIT	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (974 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
	LGALS8	Galectin. (319 aa)
	EGR3	Early growth response 3. (387 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
	GIPC2	GIPC PDZ domain containing family member 2. (313 aa)
	VHL	Uncharacterized protein. (181 aa)
	EDN2	Endothelin 2. (177 aa)
	KITLG	Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (274 aa)
	SOX18	SRY-box transcription factor 18. (393 aa)
	ADTRP	Androgen dependent TFPI regulating protein. (230 aa)
	SLIT2	Slit guidance ligand 2. (1457 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (848 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	FAT2	FAT atypical cadherin 2. (4347 aa)
	CLEC14A	C-type lectin domain containing 14A. (490 aa)
	PTP4A3	Protein tyrosine phosphatase 4A3. (173 aa)
	PLXND1	Plexin D1. (1926 aa)
	PKN1	Protein kinase N1. (950 aa)
	PKN2	Protein kinase N2. (981 aa)
	VEGFA	Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (214 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	EPHB4	ENSCHIP00000024651	ENSCHIP00000024536	Tyrosine-protein kinase.	EPH receptor B4.	0.945
ABL1	PTPN11	ENSCHIP00000024651	ENSCHIP00000020822	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.414
ABL1	RHOA	ENSCHIP00000024651	ENSCHIP00000011951	Tyrosine-protein kinase.	Ras-like protein family member A.	0.456
ABL1	ROBO1	ENSCHIP00000024651	ENSCHIP00000017456	Tyrosine-protein kinase.	Uncharacterized protein.	0.941
ABL1	SLIT2	ENSCHIP00000024651	ENSCHIP00000032261	Tyrosine-protein kinase.	Slit guidance ligand 2.	0.542
AKT1	FGF2	ENSCHIP00000027335	ENSCHIP00000019134	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.476
AKT1	IRS2	ENSCHIP00000027335	ENSCHIP00000000977	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 2.	0.544
AKT1	ITGB1	ENSCHIP00000027335	ENSCHIP00000007508	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Integrin beta; Belongs to the integrin beta chain family.	0.431
AKT1	KIT	ENSCHIP00000027335	ENSCHIP00000025751	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	0.442
AKT1	NOS3	ENSCHIP00000027335	ENSCHIP00000011023	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nitric oxide synthase; Produces nitric oxide (NO).	0.955
AKT1	NR4A1	ENSCHIP00000027335	ENSCHIP00000005611	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nuclear receptor subfamily 4 group A member 1.	0.445
AKT1	PIK3R3	ENSCHIP00000027335	ENSCHIP00000014983	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.952
AKT1	PTPN11	ENSCHIP00000027335	ENSCHIP00000020822	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.421
AKT1	RHOA	ENSCHIP00000027335	ENSCHIP00000011951	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Ras-like protein family member A.	0.529
AKT1	SNAI1	ENSCHIP00000027335	ENSCHIP00000012596	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Snail family transcriptional repressor 1.	0.400
ANLN	DAAM2	ENSCHIP00000017037	ENSCHIP00000013273	Anillin actin binding protein.	Dishevelled associated activator of morphogenesis 2.	0.560
ANLN	ENSCHIP00000011371	ENSCHIP00000017037	ENSCHIP00000011371	Anillin actin binding protein.	Uncharacterized protein.	0.725
ANLN	RHOA	ENSCHIP00000017037	ENSCHIP00000011951	Anillin actin binding protein.	Ras-like protein family member A.	0.769
ANLN	ROCK1	ENSCHIP00000017037	ENSCHIP00000015667	Anillin actin binding protein.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.513
ARSJ	VSTM4	ENSCHIP00000007488	ENSCHIP00000022895	Arylsulfatase family member J.	V-set and transmembrane domain containing 4.	0.432