STRINGSTRING
INPP5K INPP5K FLCN FLCN CRY1 CRY1 DUSP12 DUSP12 C1QTNF1 C1QTNF1 FAM3C FAM3C ADIPOQ ADIPOQ PPARA PPARA GNMT GNMT PTK2B PTK2B ENSCHIP00000031771 ENSCHIP00000031771 SIRT6 SIRT6 RORA RORA C1QTNF3 C1QTNF3 NKX1-1 NKX1-1 ENSCHIP00000030535 ENSCHIP00000030535 TP53 TP53 ENPP1 ENPP1 CBFA2T3 CBFA2T3 NLN NLN KHK KHK USP7 USP7 POMC POMC IGFBP3 IGFBP3 DYRK2 DYRK2 LOC102189022 LOC102189022 WDR5 WDR5 LEPR LEPR AKT1 AKT1 PPP1R3C PPP1R3C DGKQ DGKQ KAT2B KAT2B GPER1 GPER1 BCKDK BCKDK ENSCHIP00000025560 ENSCHIP00000025560 PDK2 PDK2 GIT1 GIT1 GCG GCG ADIPOR1 ADIPOR1 LOC102186084 LOC102186084 KAT2A KAT2A ENSCHIP00000023520 ENSCHIP00000023520 FOXK2 FOXK2 ENSCHIP00000023383 ENSCHIP00000023383 FOXK1 FOXK1 ACACB ACACB ENSCHIP00000022861 ENSCHIP00000022861 C1QTNF12 C1QTNF12 STAT3 STAT3 PPP1R3E PPP1R3E ENSCHIP00000021464 ENSCHIP00000021464 LEP LEP IGF1 IGF1 HDAC4 HDAC4 PRKCE PRKCE FOXO1 FOXO1 PPP1R3G PPP1R3G EP300 EP300 ERFE ERFE PLEK PLEK NUPR1 NUPR1 SLC35B4 SLC35B4 MIDN MIDN SIRT7 SIRT7 PARK2 PARK2 AVPR1B AVPR1B TFF3 TFF3 SERPINA12 SERPINA12 PMAIP1 PMAIP1 ZNF692 ZNF692 C1QTNF6 C1QTNF6 GCK GCK BAD BAD LCMT1 LCMT1 AKT2 AKT2 DDB1 DDB1 MST1 MST1 IGFBP4 IGFBP4 ZMPSTE24 ZMPSTE24 INSR INSR PGP PGP SCARB2 SCARB2 ACTN3 ACTN3 PTPN2 PTPN2 LOC102175794 LOC102175794 PDK4 PDK4 SIK1 SIK1 RANBP2 RANBP2 ENSCHIP00000010160 ENSCHIP00000010160 GNB3 GNB3 PPP1R3D PPP1R3D SNCA SNCA RUBCNL RUBCNL PDK1 PDK1 LOC102190194 LOC102190194 DDIT4 DDIT4 GCGR GCGR FAM3A FAM3A PHLDA2 PHLDA2 PDK3 PDK3 INS INS SIRT1 SIRT1 NCOA2 NCOA2 PPP4R3B PPP4R3B NCOR1 NCOR1 SLC4A1 SLC4A1 TIGAR TIGAR ENSCHIP00000005178 ENSCHIP00000005178 ENSCHIP00000005096 ENSCHIP00000005096 MLYCD MLYCD PPP1R3A PPP1R3A PTH PTH GPLD1 GPLD1 PASK PASK LHCGR LHCGR PPP1R3B PPP1R3B EPM2AIP1 EPM2AIP1 P2RY6 P2RY6 OGT OGT IRS2 IRS2 SLC45A3 SLC45A3 PPP1R3F PPP1R3F LOC108635363 LOC108635363
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INPP5KInositol polyphosphate-5-phosphatase K. (449 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
CRY1Cryptochrome circadian regulator 1. (593 aa)
DUSP12Uncharacterized protein. (345 aa)
C1QTNF1C1q and TNF related 1. (279 aa)
FAM3CFamily with sequence similarity 3 member C. (227 aa)
ADIPOQC1q domain-containing protein. (283 aa)
PPARAPeroxisome proliferator activated receptor alpha. (470 aa)
GNMTGlycine N-methyltransferase. (295 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ENSCHIP00000031771C2 domain-containing protein. (204 aa)
SIRT6Sirtuin 6. (335 aa)
RORAUncharacterized protein. (527 aa)
C1QTNF3C1q domain-containing protein. (319 aa)
NKX1-1NK1 homeobox 1. (375 aa)
ENSCHIP00000030535zf-RING_14 domain-containing protein. (149 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (818 aa)
CBFA2T3CBFA2/RUNX1 partner transcriptional co-repressor 3. (714 aa)
NLNNeurolysin. (705 aa)
KHKKetohexokinase. (298 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1103 aa)
POMCProopiomelanocortin. (270 aa)
IGFBP3Uncharacterized protein. (293 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (599 aa)
LOC102189022Uncharacterized protein. (464 aa)
WDR5WD repeat domain 5. (334 aa)
LEPRLeptin receptor. (1166 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (318 aa)
DGKQDiacylglycerol kinase theta. (785 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (810 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (363 aa)
BCKDKProtein-serine/threonine kinase. (412 aa)
ENSCHIP00000025560Ig-like domain-containing protein. (271 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
GIT1GIT ArfGAP 1. (738 aa)
GCGGlucagon. (180 aa)
ADIPOR1Uncharacterized protein. (375 aa)
LOC102186084Uncharacterized protein. (293 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
ENSCHIP00000023520Uncharacterized protein; Belongs to the CD36 family. (395 aa)
FOXK2Forkhead box K2. (658 aa)
ENSCHIP00000023383RBR-type E3 ubiquitin transferase. (84 aa)
FOXK1Forkhead box K1. (708 aa)
ACACBAcetyl-CoA carboxylase beta. (2448 aa)
ENSCHIP00000022861Protein-serine/threonine kinase. (377 aa)
C1QTNF12C1q and TNF related 12. (292 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
ENSCHIP00000021464Uncharacterized protein. (135 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (608 aa)
FOXO1Forkhead box O1. (668 aa)
PPP1R3GProtein phosphatase 1 regulatory subunit 3G. (334 aa)
EP300E1A binding protein p300. (2411 aa)
ERFEErythroferrone. (331 aa)
PLEKPleckstrin. (356 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
SLC35B4Solute carrier family 35 member B4. (331 aa)
MIDNMidnolin. (505 aa)
SIRT7Sirtuin 7. (405 aa)
PARK2Ubiquitin-like domain-containing protein. (293 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa)
TFF3Trefoil factor 3. (81 aa)
SERPINA12Serpin family A member 12; Belongs to the serpin family. (430 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
ZNF692Zinc finger protein 692. (511 aa)
C1QTNF6C1q and TNF related 6. (266 aa)
GCKPhosphotransferase. (465 aa)
BADBCL2 associated agonist of cell death. (198 aa)
LCMT1Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (335 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (722 aa)
IGFBP4IBP4. (258 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
INSRTyrosine-protein kinase receptor. (1365 aa)
PGPPhosphoglycolate phosphatase; Belongs to the HAD-like hydrolase superfamily. (323 aa)
SCARB2Uncharacterized protein; Belongs to the CD36 family. (478 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (902 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (417 aa)
LOC102175794Uncharacterized protein. (282 aa)
PDK4Protein-serine/threonine kinase. (407 aa)
SIK1Uncharacterized protein. (778 aa)
RANBP2RAN binding protein 2. (3077 aa)
ENSCHIP00000010160Uncharacterized protein. (252 aa)
GNB3G protein subunit beta 3. (338 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
RUBCNLRubicon like autophagy enhancer. (662 aa)
PDK1Protein-serine/threonine kinase. (438 aa)
LOC102190194Uncharacterized protein. (935 aa)
DDIT4DNA damage inducible transcript 4. (229 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (490 aa)
FAM3AFamily with sequence similarity 3 member A. (223 aa)
PHLDA2Pleckstrin homology like domain family A member 2. (128 aa)
PDK3Protein-serine/threonine kinase. (415 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (732 aa)
NCOA2Nuclear receptor coactivator. (1473 aa)
PPP4R3BProtein phosphatase 4 regulatory subunit 3B. (820 aa)
NCOR1Nuclear receptor corepressor 1. (2447 aa)
SLC4A1Anion exchange protein. (978 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
ENSCHIP00000005178Uncharacterized protein. (156 aa)
ENSCHIP00000005096Uncharacterized protein. (282 aa)
MLYCDMalonyl-CoA decarboxylase. (524 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1148 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (848 aa)
PASKPAS domain containing serine/threonine kinase. (1273 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (700 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (339 aa)
EPM2AIP1EPM2A interacting protein 1. (608 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
IRS2Insulin receptor substrate 2. (1465 aa)
SLC45A3Solute carrier family 45 member 3. (550 aa)
PPP1R3FCBM21 domain-containing protein. (769 aa)
LOC108635363Ig-like domain-containing protein. (298 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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