STRINGSTRING
RB1 RB1 NKX6-2 NKX6-2 PLAG1 PLAG1 ATOH1 ATOH1 HES1 HES1 GSX2 GSX2 NR1D1 NR1D1 CLCF1 CLCF1 SOX8 SOX8 PRKCH PRKCH UFL1 UFL1 SERPINE2 SERPINE2 DAAM2 DAAM2 DLX1 DLX1 NTN1 NTN1 NR2E1 NR2E1 HDAC1 HDAC1 TNFRSF1B TNFRSF1B IL34 IL34 SOX10 SOX10 MTOR MTOR LDLR LDLR HES5 HES5 DLX6 DLX6 MECP2 MECP2 SHH SHH GFAP GFAP NKX6-1 NKX6-1 VEGFC VEGFC F2 F2 ZNF365 ZNF365 IL1B IL1B DLX2 DLX2 SOX11 SOX11 TP53 TP53 NKX2-2 NKX2-2 ASPA ASPA CTNNB1 CTNNB1 PRKCI PRKCI KRAS KRAS ENSCHIP00000033272 ENSCHIP00000033272 PTN PTN TENM4 TENM4 TMEM98 TMEM98 LIF LIF NF2 NF2 BMP2 BMP2 TGFB1 TGFB1 NOTCH1 NOTCH1 SKI SKI NF1 NF1 GPR37L1 GPR37L1 NOG NOG RNF112 RNF112 TNF TNF TREM2 TREM2 IL6ST IL6ST LRP2 LRP2 EGR2 EGR2 BIN1 BIN1 EZH2 EZH2 OLIG2 OLIG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RB1RB transcriptional corepressor 1. (931 aa)
NKX6-2NK6 homeobox 2. (286 aa)
PLAG1PLAG1 zinc finger. (499 aa)
ATOH1Atonal bHLH transcription factor 1. (352 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
GSX2GS homeobox 2. (305 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (616 aa)
CLCF1Cardiotrophin like cytokine factor 1. (220 aa)
SOX8SRY-box transcription factor 8. (534 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
UFL1UFM1 specific ligase 1. (792 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (397 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1087 aa)
DLX1Distal-less homeobox 1. (255 aa)
NTN1Netrin 1. (496 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (464 aa)
TNFRSF1BTNF receptor superfamily member 1B. (459 aa)
IL34Interleukin 34. (233 aa)
SOX10SRY-box transcription factor 10. (469 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
LDLRLow density lipoprotein receptor. (787 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
DLX6Distal-less homeobox 6. (230 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (481 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (428 aa)
NKX6-1NK6 homeobox 1. (367 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
ZNF365Zinc finger protein 365. (406 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
DLX2Distal-less homeobox 2. (328 aa)
SOX11Transcription factor SOX. (444 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
NKX2-2NK2 homeobox 2. (273 aa)
ASPAAspartoacylase. (313 aa)
CTNNB1Catenin beta 1. (781 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (636 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ENSCHIP00000033272FERM domain-containing protein. (580 aa)
PTNPleiotrophin. (183 aa)
TENM4Teneurin transmembrane protein 4. (2855 aa)
TMEM98Transmembrane protein 98. (226 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
NF2FERM domain-containing protein. (612 aa)
BMP2TGF_BETA_2 domain-containing protein. (381 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
NOTCH1Notch receptor 1. (2508 aa)
SKISKI proto-oncogene. (729 aa)
NF1Neurofibromin 1. (2848 aa)
GPR37L1G protein-coupled receptor 37 like 1. (478 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
RNF112Ring finger protein 112. (628 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
LRP2LDL receptor related protein 2. (4649 aa)
EGR2Early growth response 2. (472 aa)
BIN1Bridging integrator 1. (587 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
OLIG2Oligodendrocyte transcription factor 2. (329 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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