STRINGSTRING
ENSCHIP00000000025 ENSCHIP00000000025 ENSCHIP00000000097 ENSCHIP00000000097 WNT8A WNT8A FZD9 FZD9 BCL7B BCL7B STK4 STK4 BCL9L BCL9L GRK5 GRK5 CTDNEP1 CTDNEP1 LRRFIP1 LRRFIP1 FZD5 FZD5 AMOTL1 AMOTL1 CUL3 CUL3 TNKS TNKS FRAT1 FRAT1 FZD10 FZD10 SFRP4 SFRP4 WNT2B WNT2B EXT1 EXT1 WNT9A WNT9A TCF7L2 TCF7L2 FRAT2 FRAT2 BCL9 BCL9 AXIN1 AXIN1 CXXC4 CXXC4 CCND1 CCND1 DLX3 DLX3 TCF7L1 TCF7L1 STK3 STK3 EDA EDA SLC9A3R1 SLC9A3R1 ENSCHIP00000007326 ENSCHIP00000007326 WNT10B WNT10B VAX2 VAX2 WNT2 WNT2 CELA1 CELA1 CSNK1G1 CSNK1G1 EDNRB EDNRB MBD2 MBD2 CDH3 CDH3 PAF1 PAF1 EDN1 EDN1 DDIT3 DDIT3 CSNK1D CSNK1D CSNK1G2 CSNK1G2 LDB1 LDB1 NDRG2 NDRG2 SOSTDC1 SOSTDC1 FZD1 FZD1 TAX1BP3 TAX1BP3 FGF10 FGF10 CTHRC1 CTHRC1 TGFB1I1 TGFB1I1 BMP2 BMP2 TLE5 TLE5 DVL3 DVL3 LOC108636861 LOC108636861 CSNK2B CSNK2B NDP NDP RSPO3 RSPO3 DIXDC1 DIXDC1 KLHL12 KLHL12 MYOC MYOC SFRP1 SFRP1 WNT5B WNT5B PRKAA2 PRKAA2 ENSCHIP00000013021 ENSCHIP00000013021 GSK3B GSK3B WNT7B WNT7B CBY1 CBY1 AMOTL2 AMOTL2 LRP6 LRP6 LOC102181663 LOC102181663 DDB1 DDB1 DVL1 DVL1 SIAH2 SIAH2 RSPO4 RSPO4 KREMEN2 KREMEN2 WLS WLS VANGL2 VANGL2 PORCN PORCN WNT5A WNT5A WNT3A WNT3A WNT16 WNT16 PKD1 PKD1 CALCOCO1 CALCOCO1 CCDC88C CCDC88C APC2 APC2 YAP1 YAP1 FZD6 FZD6 RAPGEF1 RAPGEF1 TMEM88 TMEM88 LY6G5B LY6G5B PRKAA1 PRKAA1 LZTS2 LZTS2 ARL6 ARL6 CELSR1 CELSR1 BARX1 BARX1 WWOX-2 WWOX-2 NXN NXN FGF2 FGF2 FOXO3 FOXO3 TLE3 TLE3 GPC3 GPC3 SDC1 SDC1 WNT3 WNT3 GRHL3 GRHL3 WNT1 WNT1 TLE1 TLE1 CAV1 CAV1 ENSCHIP00000021059 ENSCHIP00000021059 LRP5 LRP5 TLE4 TLE4 EDNRA EDNRA PTK7 PTK7 SOST SOST RSPO2 RSPO2 PKD2 PKD2 KREMEN1 KREMEN1 AXIN2 AXIN2 FGF9 FGF9 CSNK2A2 CSNK2A2 LATS2 LATS2 FRZB FRZB WWOX WWOX SOX9 SOX9 WNT11 WNT11 MITF MITF NKD1 NKD1 RECK RECK DRAXIN DRAXIN GSC GSC WNT8B WNT8B SCYL2 SCYL2 WNT7A WNT7A ISL1 ISL1 CSNK2A1 CSNK2A1 TMEM198 TMEM198 PLPP3 PLPP3 RNF146 RNF146 NKD2 NKD2 NLK NLK PYGO2 PYGO2 WNT10A WNT10A SFRP2 SFRP2 LOC102180576 LOC102180576 ZRANB1 ZRANB1 EPM2A EPM2A C12orf43 C12orf43 RYK RYK CCDC90B CCDC90B MESD MESD WNT6 WNT6 GID8 GID8 FZD3 FZD3 SHH SHH RSPO1 RSPO1 HESX1 HESX1 FERMT2 FERMT2 CTNNBIP1 CTNNBIP1 LRRC45 LRRC45 HBP1 HBP1 APC APC SFRP5 SFRP5 CCNE1 CCNE1 LRP4 LRP4 STRN STRN IFT80 IFT80 DDX3X DDX3X PYGO1 PYGO1 HMGXB4 HMGXB4 GATA3 GATA3 CPE CPE ETV2 ETV2 CSNK1G3 CSNK1G3 CELSR2 CELSR2 LEF1 LEF1 ENSCHIP00000030683 ENSCHIP00000030683 RAB5A RAB5A CTNNB1 CTNNB1 DVL2 DVL2 FZD4 FZD4 FZD7 FZD7 JUP JUP CYLD CYLD WNT4 WNT4 FZD8 FZD8 WDR61 WDR61 MED12 MED12 TLE2 TLE2 WNT9B WNT9B ROR1 ROR1 TCF7 TCF7 GSK3A GSK3A LGR4 LGR4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCHIP00000000025Uncharacterized protein. (552 aa)
ENSCHIP00000000097Med12-PQL domain-containing protein. (315 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (589 aa)
BCL7BBAF chromatin remodeling complex subunit BCL7B. (202 aa)
STK4Serine/threonine kinase 4. (487 aa)
BCL9LBCL9 like. (1495 aa)
GRK5G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (555 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (244 aa)
LRRFIP1Uncharacterized protein. (411 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
AMOTL1Angiomotin like 1. (975 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
FRAT1Uncharacterized protein. (276 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
SFRP4Secreted frizzled related protein 4. (346 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (446 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
TCF7L2Transcription factor 7 like 2. (669 aa)
FRAT2FRAT regulator of WNT signaling pathway 2. (229 aa)
BCL9BCL9 transcription coactivator. (1426 aa)
AXIN1Axin 1. (867 aa)
CXXC4CXXC finger protein 4. (373 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
DLX3Distal-less homeobox 3. (287 aa)
TCF7L1Transcription factor 7 like 1. (587 aa)
STK3Serine/threonine kinase 3. (495 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (257 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (386 aa)
ENSCHIP00000007326WD_REPEATS_REGION domain-containing protein. (189 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
VAX2Ventral anterior homeobox 2. (286 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
CELA1Chymotrypsin like elastase 1; Belongs to the peptidase S1 family. (266 aa)
CSNK1G1Casein kinase 1 gamma 1. (463 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (441 aa)
MBD2Methyl-CpG binding domain protein 2. (414 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (831 aa)
PAF1Uncharacterized protein. (501 aa)
EDN1Endothelin 1. (202 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (415 aa)
CSNK1G2Casein kinase 1 gamma 2; Belongs to the protein kinase superfamily. (414 aa)
LDB1LIM domain binding 1. (411 aa)
NDRG2NDRG family member 2. (371 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (552 aa)
TAX1BP3Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. (124 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
CTHRC1Collagen triple helix repeat containing 1. (243 aa)
TGFB1I1Transforming growth factor beta 1 induced transcript 1. (415 aa)
BMP2TGF_BETA_2 domain-containing protein. (381 aa)
TLE5TLE family member 5, transcriptional modulator. (197 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
LOC108636861RING-type domain-containing protein. (341 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (217 aa)
NDPNorrin cystine knot growth factor NDP. (133 aa)
RSPO3R-spondin 3. (303 aa)
DIXDC1DIX domain containing 1. (689 aa)
KLHL12Kelch like family member 12. (568 aa)
MYOCMyocilin. (490 aa)
SFRP1Secreted frizzled related protein 1. (308 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
ENSCHIP00000013021WD_REPEATS_REGION domain-containing protein. (324 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (416 aa)
CBY1Uncharacterized protein. (127 aa)
AMOTL2Angiomotin like 2. (767 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
LOC102181663Uncharacterized protein. (119 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
DVL1Dishevelled segment polarity protein 1. (682 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (333 aa)
RSPO4R-spondin 4. (232 aa)
KREMEN2Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (454 aa)
WLSWnt ligand secretion mediator. (567 aa)
VANGL2Vang-like protein. (522 aa)
PORCNPorcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (461 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4303 aa)
CALCOCO1Calcium binding and coiled-coil domain 1. (717 aa)
CCDC88CCoiled-coil domain containing 88C. (2021 aa)
APC2APC regulator of WNT signaling pathway 2. (2305 aa)
YAP1Yes associated protein 1. (503 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (714 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1077 aa)
TMEM88Transmembrane protein 88. (159 aa)
LY6G5BLymphocyte antigen 6 family member G5B. (196 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (672 aa)
ARL6ADP ribosylation factor like GTPase 6; Belongs to the small GTPase superfamily. Arf family. (185 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2710 aa)
BARX1BARX homeobox 1. (254 aa)
WWOX-2Uncharacterized protein. (208 aa)
NXNNucleoredoxin. (457 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
FOXO3Forkhead box O3. (672 aa)
TLE3TLE family member 3, transcriptional corepressor. (769 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (509 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (312 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
GRHL3Grainyhead like transcription factor 3. (600 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
TLE1TLE family member 1, transcriptional corepressor. (770 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
ENSCHIP00000021059Uncharacterized protein. (63 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
TLE4TLE family member 4, transcriptional corepressor. (774 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
SOSTSclerostin. (212 aa)
RSPO2R-spondin 2. (243 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (978 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (462 aa)
AXIN2Axin 2. (844 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
LATS2Large tumor suppressor kinase 2. (1015 aa)
FRZBFrizzled related protein. (325 aa)
WWOXUncharacterized protein. (153 aa)
SOX9SRY-box transcription factor 9. (525 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
MITFMelanocyte inducing transcription factor. (519 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (471 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (971 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (346 aa)
GSCGoosecoid homeobox. (257 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
SCYL2SCY1 like pseudokinase 2. (866 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ISL1ISL LIM homeobox 1. (349 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
TMEM198Transmembrane protein 198. (360 aa)
PLPP3acidPPc domain-containing protein. (312 aa)
RNF146Uncharacterized protein. (352 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (483 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
PYGO2Pygopus family PHD finger 2. (392 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (416 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
LOC102180576Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
ZRANB1Zinc finger RANBP2-type containing 1. (734 aa)
EPM2AEPM2A glucan phosphatase, laforin. (331 aa)
C12orf43Chromosome 12 open reading frame 43. (246 aa)
RYKReceptor like tyrosine kinase. (609 aa)
CCDC90BCoiled-coil domain containing 90B. (256 aa)
MESDMesoderm development LRP chaperone. (232 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
GID8GID complex subunit 8 homolog. (228 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
RSPO1Ovarian R-spondin member 1. (262 aa)
HESX1HESX homeobox 1. (185 aa)
FERMT2Fermitin family member 2. (680 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
LRRC45Leucine rich repeat containing 45. (671 aa)
HBP1HMG-box transcription factor 1. (512 aa)
APCAPC regulator of WNT signaling pathway. (2880 aa)
SFRP5Secreted frizzled related protein 5. (320 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (411 aa)
LRP4LDL receptor related protein 4. (1901 aa)
STRNStriatin. (780 aa)
IFT80Intraflagellar transport 80. (771 aa)
DDX3XUncharacterized protein; Belongs to the DEAD box helicase family. (661 aa)
PYGO1Pygopus family PHD finger 1. (412 aa)
HMGXB4HMG-box containing 4. (602 aa)
GATA3GATA binding protein 3. (467 aa)
CPECarboxypeptidase E. (474 aa)
ETV2ETS domain-containing protein. (153 aa)
CSNK1G3Casein kinase 1 gamma 3; Belongs to the protein kinase superfamily. (454 aa)
CELSR2Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2921 aa)
LEF1HMG box domain-containing protein. (430 aa)
ENSCHIP00000030683Uncharacterized protein. (66 aa)
RAB5AUncharacterized protein. (215 aa)
CTNNB1Catenin beta 1. (781 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (555 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa)
JUPJunction plakoglobin. (745 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (665 aa)
WDR61WD_REPEATS_REGION domain-containing protein. (305 aa)
MED12Med12 domain-containing protein. (2040 aa)
TLE2TLE family member 2, transcriptional corepressor. (844 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (932 aa)
TCF7Transcription factor 7. (418 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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