STRINGSTRING
TNMD TNMD HOXA5 HOXA5 GPR4 GPR4 ECSCR ECSCR ADAMTS1 ADAMTS1 DAB2IP DAB2IP E2F2 E2F2 IL17F IL17F SPRY2 SPRY2 GTF2I GTF2I TNF TNF KLF2 KLF2 CREB3L1 CREB3L1 PML PML PDE3B PDE3B PGK1 PGK1 STAT1 STAT1 NF1 NF1 SPRED1 SPRED1 ATF2 ATF2 ISM1 ISM1 CNMD CNMD AGO1 AGO1 EPN1 EPN1 TBC1D31 TBC1D31 FOXO4 FOXO4 ROCK2 ROCK2 TIE1 TIE1 ENSCHIP00000011638 ENSCHIP00000011638 TEK TEK NAXE NAXE ADGRB3 ADGRB3 VASH1 VASH1 PTPRM PTPRM CXCL10 CXCL10 SULF1 SULF1 EPN2 EPN2 SERPINF1 SERPINF1 COL4A2 COL4A2 PLK2 PLK2 CTNNB1 CTNNB1 HRG HRG MINAR1 MINAR1 HGS HGS ADGRB2 ADGRB2 THBS4 THBS4 APOH APOH LOC102175359 LOC102175359 KRIT1 KRIT1 EFNA3 EFNA3 ENSCHIP00000027082 ENSCHIP00000027082 MECP2 MECP2 ALOX5 ALOX5 SEMA4A SEMA4A FASLG FASLG TGFB2 TGFB2 SYNJ2BP SYNJ2BP LOC102176524 LOC102176524 SPARC SPARC FOXJ2 FOXJ2 SERPINE1 SERPINE1 EMILIN1 EMILIN1 CLDN5 CLDN5 SEMA3E SEMA3E PIK3CB PIK3CB SARS1 SARS1 ENSCHIP00000020611 ENSCHIP00000020611 ANGPT2 ANGPT2 ADGRB1 ADGRB1 ANGPT4 ANGPT4 SEMA6A SEMA6A DCN DCN THBS1 THBS1 THBS2 THBS2 ROCK1 ROCK1 CHGA CHGA EPHA2 EPHA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNMDTenomodulin. (318 aa)
HOXA5Homeobox A5. (270 aa)
GPR4G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (362 aa)
ECSCRUncharacterized protein. (253 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (971 aa)
DAB2IPDAB2 interacting protein. (1198 aa)
E2F2E2F transcription factor 2. (437 aa)
IL17FUncharacterized protein. (178 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
GTF2IGeneral transcription factor IIi. (999 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
KLF2Kruppel like factor 2. (361 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (581 aa)
PMLPromyelocytic leukemia. (868 aa)
PDE3BPhosphodiesterase. (1115 aa)
PGK1Phosphoglycerate kinase. (424 aa)
STAT1Signal transducer and activator of transcription. (834 aa)
NF1Neurofibromin 1. (2848 aa)
SPRED1Sprouty related EVH1 domain containing 1. (433 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ISM1Isthmin 1. (464 aa)
CNMDChondromodulin. (335 aa)
AGO1Uncharacterized protein; Belongs to the argonaute family. (916 aa)
EPN1Epsin 1. (576 aa)
TBC1D31TBC1 domain family member 31. (1062 aa)
FOXO4Forkhead box O4. (535 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1139 aa)
ENSCHIP00000011638DUF1785 domain-containing protein. (242 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
NAXENAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (288 aa)
ADGRB3Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1282 aa)
VASH1Vasohibin 1. (363 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1495 aa)
CXCL10C-X-C motif chemokine. (102 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (868 aa)
EPN2Epsin 2. (597 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (416 aa)
COL4A2Collagen type IV alpha 2 chain. (1607 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
CTNNB1Catenin beta 1. (781 aa)
HRGHistidine rich glycoprotein. (531 aa)
MINAR1Membrane integral NOTCH2 associated receptor 1. (917 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
ADGRB2Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1560 aa)
THBS4Thrombospondin 4. (965 aa)
APOHApolipoprotein H. (355 aa)
LOC102175359PDZ domain-containing protein. (136 aa)
KRIT1Uncharacterized protein. (736 aa)
EFNA3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (232 aa)
ENSCHIP00000027082Uncharacterized protein. (731 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (481 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (762 aa)
FASLGFasL; Belongs to the tumor necrosis factor family. (277 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
LOC102176524Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1242 aa)
SPARCOsteonectin. (303 aa)
FOXJ2Forkhead box J2. (561 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
EMILIN1Elastin microfibril interfacer 1. (1017 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
SARS1Seryl-tRNA synthetase. (514 aa)
ENSCHIP00000020611Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (291 aa)
ANGPT2Angiopoietin 2. (498 aa)
ADGRB1Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1560 aa)
ANGPT4Angiopoietin 4. (498 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1046 aa)
DCNDecorin; May affect the rate of fibrils formation. (360 aa)
THBS1Thrombospondin 1. (1218 aa)
THBS2Thrombospondin 2. (1181 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
CHGAChromogranin A. (534 aa)
EPHA2EPH receptor A2. (975 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.