STRINGSTRING
PPP6R2 PPP6R2 SPTBN4 SPTBN4 STX17 STX17 EIF2AK3 EIF2AK3 SOD1 SOD1 SH3RF2 SH3RF2 CHCHD3 CHCHD3 TSC2 TSC2 PAWR PAWR LCK LCK FBXL2 FBXL2 SMAD3 SMAD3 PPME1 PPME1 FLT4 FLT4 ENSCHIP00000011519 ENSCHIP00000011519 NFATC2 NFATC2 PPP1R36 PPP1R36 PPP1R18 PPP1R18 C20orf27 C20orf27 SHOC2 SHOC2 PPP1R27 PPP1R27 JAK1 JAK1 PPP1R32 PPP1R32 PPP1R3D PPP1R3D PPP1R16B PPP1R16B SYK SYK WNK1 WNK1 GTF2F1 GTF2F1 CNST CNST SKAP2 SKAP2 MASTL MASTL PDLIM4 PDLIM4 LOC102188481 LOC102188481 LGALS3 LGALS3 CLEC12B CLEC12B ENSA ENSA MTMR9 MTMR9 IGBP1 IGBP1 AKAP5 AKAP5 SPRED1 SPRED1 SLC9A3R1 SLC9A3R1 DLG1 DLG1 IQGAP1 IQGAP1 HSP90B1 HSP90B1 NEK2 NEK2 TCTEX1D4 TCTEX1D4 JAK3 JAK3 PPP1R3A PPP1R3A ANAPC5 ANAPC5 MVP MVP SMG5 SMG5 PPP1R10 PPP1R10 ENSCHIP00000003109 ENSCHIP00000003109 DAB2IP DAB2IP PPP1R3B PPP1R3B TRAF2 TRAF2 PIK3R2 PIK3R2 PPP3R1 PPP3R1 SNX3 SNX3 SMTNL1 SMTNL1 AP3B2 AP3B2 CLEC12A CLEC12A ENSCHIP00000001327 ENSCHIP00000001327 PPP1R3F PPP1R3F SH2D4B SH2D4B ENSCHIP00000000365 ENSCHIP00000000365 CEP192 CEP192 MAPK1 MAPK1 PPP3CB PPP3CB PPP1R9B PPP1R9B STAT6 STAT6 CTNNB1 CTNNB1 ENSCHIP00000030705 ENSCHIP00000030705 TP53 TP53 MET MET ENSCHIP00000030069 ENSCHIP00000030069 STRN STRN STYXL1 STYXL1 TPRN TPRN GNA12 GNA12 LOC102189022 LOC102189022 MAP3K5 MAP3K5 ANKLE2 ANKLE2 FAM71F1 FAM71F1 SLC9A1 SLC9A1 ANAPC4 ANAPC4 FCRL6 FCRL6 CRY1 CRY1 PHACTR1 PHACTR1 RCAN3 RCAN3 LOC102176524 LOC102176524 CSF1R CSF1R RAD51 RAD51 SKAP1 SKAP1 DZIP3 DZIP3 ENSCHIP00000024754 ENSCHIP00000024754 SPHK1 SPHK1 PPP1R15A PPP1R15A ERBB2 ERBB2 JUP JUP TRAF3 TRAF3 ENSCHIP00000032620 ENSCHIP00000032620 CRY2 CRY2 ENSCHIP00000027893 ENSCHIP00000027893 YWHAE YWHAE SH3YL1 SH3YL1 PPP1R3C PPP1R3C ENSCHIP00000026753 ENSCHIP00000026753 TBK1 TBK1 CADM4 CADM4 MTMR4 MTMR4 CD22 CD22 MAST2 MAST2 BOD1 BOD1 TERF2IP TERF2IP FBXO41 FBXO41 ITGA1 ITGA1 PIK3R1 PIK3R1 PPP1R16A PPP1R16A PHACTR3 PHACTR3 KCNQ1 KCNQ1 EGFR EGFR PPP6R3 PPP6R3 STAT3 STAT3 SMAD2 SMAD2 TRPC4AP TRPC4AP FBXL20 FBXL20 ANAPC7 ANAPC7 ENSCHIP00000021995 ENSCHIP00000021995 PPP1R3E PPP1R3E CDC27 CDC27 SFI1 SFI1 SBF2 SBF2 KIFAP3 KIFAP3 STRN4 STRN4 ENSCHIP00000020611 ENSCHIP00000020611 STRN3 STRN3 LRRD1 LRRD1 PPP1R11 PPP1R11 SH2D4A SH2D4A AP3B1 AP3B1 FAM71F2 FAM71F2 PTPA PTPA VCP VCP CTTNBP2NL CTTNBP2NL FOXO1 FOXO1 KCNN4 KCNN4 ELL ELL PPP1R3G PPP1R3G PPP1R35 PPP1R35 HMCN2 HMCN2 VRK3 VRK3 ARPP19 ARPP19 PHACTR4 PHACTR4 CSRNP2 CSRNP2 MFHAS1 MFHAS1 DLG3 DLG3 BOD1L1 BOD1L1 PPP6R1 PPP6R1 AMBRA1 AMBRA1 ENSCHIP00000016214 ENSCHIP00000016214 SLC9A3R2 SLC9A3R2 MTMR3 MTMR3 FER FER ROS1 ROS1 SMTNL2 SMTNL2 BCL2 BCL2 MAPK3 MAPK3 GRB2 GRB2 CDKN1B CDKN1B ENSCHIP00000015156 ENSCHIP00000015156 LOC102171800 LOC102171800 RACK1 RACK1 CDH5 CDH5 BAD BAD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP6R2Protein phosphatase 6 regulatory subunit 2. (917 aa)
SPTBN4Spectrin beta chain; Belongs to the spectrin family. (2564 aa)
STX17Syntaxin 17; Belongs to the syntaxin family. (301 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1114 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
SH3RF2SH3 domain containing ring finger 2. (728 aa)
CHCHD3MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (232 aa)
TSC2Rap-GAP domain-containing protein. (1817 aa)
PAWRPro-apoptotic WT1 regulator. (345 aa)
LCKTyrosine-protein kinase. (509 aa)
FBXL2F-box and leucine rich repeat protein 2. (424 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PPME1Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. (378 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1365 aa)
ENSCHIP00000011519Uncharacterized protein. (439 aa)
NFATC2Nuclear factor of activated T cells 2. (914 aa)
PPP1R36Protein phosphatase 1 regulatory subunit 36. (390 aa)
PPP1R18Protein phosphatase 1 regulatory subunit 18. (606 aa)
C20orf27Chromosome 20 open reading frame 27. (174 aa)
SHOC2SHOC2 leucine rich repeat scaffold protein. (582 aa)
PPP1R27Protein phosphatase 1 regulatory subunit 27. (154 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
PPP1R32Protein phosphatase 1 regulatory subunit 32. (428 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
PPP1R16BProtein phosphatase 1 regulatory subunit 16B. (568 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
WNK1WNK lysine deficient protein kinase 1. (2367 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (546 aa)
CNSTConsortin, connexin sorting protein. (721 aa)
SKAP2Src kinase associated phosphoprotein 2. (358 aa)
MASTLMicrotubule associated serine/threonine kinase like. (881 aa)
PDLIM4PDZ and LIM domain 4. (331 aa)
LOC102188481Uncharacterized protein. (379 aa)
LGALS3Galectin. (260 aa)
CLEC12BC-type lectin domain family 12 member B. (276 aa)
ENSAEndosulfine alpha; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (121 aa)
MTMR9Myotubularin related protein 9. (549 aa)
IGBP1Uncharacterized protein. (338 aa)
AKAP5A-kinase anchoring protein 5. (428 aa)
SPRED1Sprouty related EVH1 domain containing 1. (433 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (386 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
HSP90B1Heat shock protein 90 beta family member 1. (836 aa)
NEK2NIMA related kinase 2. (445 aa)
TCTEX1D4Tctex1 domain containing 4. (218 aa)
JAK3Tyrosine-protein kinase. (1138 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1148 aa)
ANAPC5Anaphase promoting complex subunit 5. (747 aa)
MVPMajor vault protein. (890 aa)
SMG5SMG5 nonsense mediated mRNA decay factor. (1016 aa)
PPP1R10Protein phosphatase 1 regulatory subunit 10. (920 aa)
ENSCHIP00000003109WD_REPEATS_REGION domain-containing protein. (59 aa)
DAB2IPDAB2 interacting protein. (1198 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (339 aa)
TRAF2TNF receptor-associated factor. (497 aa)
PIK3R2Uncharacterized protein. (724 aa)
PPP3R1Uncharacterized protein. (170 aa)
SNX3Sorting nexin 3. (162 aa)
SMTNL1Smoothelin like 1. (477 aa)
AP3B2AP-3 complex subunit beta. (1075 aa)
CLEC12AC-type lectin domain family 12 member A. (265 aa)
ENSCHIP00000001327Uncharacterized protein. (185 aa)
PPP1R3FCBM21 domain-containing protein. (769 aa)
SH2D4BSH2 domain containing 4B. (431 aa)
ENSCHIP00000000365Uncharacterized protein. (304 aa)
CEP192Uncharacterized protein. (429 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
PPP3CBSerine/threonine-protein phosphatase. (535 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (823 aa)
STAT6Signal transducer and activator of transcription. (841 aa)
CTNNB1Catenin beta 1. (781 aa)
ENSCHIP0000003070514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (206 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1384 aa)
ENSCHIP00000030069PDZ domain-containing protein. (123 aa)
STRNStriatin. (780 aa)
STYXL1Serine/threonine/tyrosine interacting like 1. (314 aa)
TPRNTaperin. (706 aa)
GNA12G protein subunit alpha 12. (382 aa)
LOC102189022Uncharacterized protein. (464 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1366 aa)
ANKLE2Ankyrin repeat and LEM domain containing 2. (967 aa)
FAM71F1Family with sequence similarity 71 member F1. (358 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (818 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (805 aa)
FCRL6Uncharacterized protein. (367 aa)
CRY1Cryptochrome circadian regulator 1. (593 aa)
PHACTR1Phosphatase and actin regulator. (651 aa)
RCAN3RCAN family member 3. (241 aa)
LOC102176524Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1242 aa)
CSF1RColony stimulating factor 1 receptor. (958 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
SKAP1Src kinase associated phosphoprotein 1. (309 aa)
DZIP3DAZ interacting zinc finger protein 3. (1189 aa)
ENSCHIP00000024754L27_1 domain-containing protein. (61 aa)
SPHK1Sphingosine kinase 1. (392 aa)
PPP1R15AProtein phosphatase 1 regulatory subunit 15A. (673 aa)
ERBB2Receptor protein-tyrosine kinase. (1250 aa)
JUPJunction plakoglobin. (745 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
ENSCHIP00000032620Uncharacterized protein. (199 aa)
CRY2Cryptochrome circadian regulator 2. (596 aa)
ENSCHIP00000027893Uncharacterized protein. (123 aa)
YWHAE14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (243 aa)
SH3YL1SH3 and SYLF domain containing 1. (400 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (318 aa)
ENSCHIP00000026753Uncharacterized protein. (107 aa)
TBK1TANK binding kinase 1. (734 aa)
CADM4Cell adhesion molecule 4. (388 aa)
MTMR4Myotubularin related protein 4. (1212 aa)
CD22CD22 molecule. (843 aa)
MAST2Microtubule associated serine/threonine kinase 2. (1689 aa)
BOD1Uncharacterized protein. (185 aa)
TERF2IPUncharacterized protein. (400 aa)
FBXO41F-box protein 41. (863 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PPP1R16AProtein phosphatase 1 regulatory subunit 16A. (514 aa)
PHACTR3Phosphatase and actin regulator. (560 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (670 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
PPP6R3Protein phosphatase 6 regulatory subunit 3. (879 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
TRPC4APTransient receptor potential cation channel subfamily C member 4 associated protein. (797 aa)
FBXL20F-box and leucine rich repeat protein 20. (428 aa)
ANAPC7Anaphase promoting complex subunit 7. (598 aa)
ENSCHIP00000021995Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (239 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
CDC27Cell division cycle 27. (824 aa)
SFI1Uncharacterized protein. (677 aa)
SBF2SET binding factor 2. (1881 aa)
KIFAP3Kinesin associated protein 3. (749 aa)
STRN4Striatin 4. (760 aa)
ENSCHIP00000020611Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (291 aa)
STRN3Striatin 3. (797 aa)
LRRD1Leucine rich repeats and death domain containing 1. (863 aa)
PPP1R11Protein phosphatase 1 regulatory inhibitor subunit 11. (126 aa)
SH2D4ASH2 domain containing 4A. (450 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1094 aa)
FAM71F2Family with sequence similarity 71 member F2. (300 aa)
PTPASerine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (317 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (816 aa)
CTTNBP2NLCTTNBP2 N-terminal like. (639 aa)
FOXO1Forkhead box O1. (668 aa)
KCNN4Potassium calcium-activated channel subfamily N member 4. (428 aa)
ELLElongation factor for RNA polymerase II. (599 aa)
PPP1R3GProtein phosphatase 1 regulatory subunit 3G. (334 aa)
PPP1R35Protein phosphatase 1 regulatory subunit 35. (268 aa)
HMCN2Hemicentin 2. (4946 aa)
VRK3VRK serine/threonine kinase 3. (434 aa)
ARPP19Uncharacterized protein; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (107 aa)
PHACTR4Phosphatase and actin regulator. (714 aa)
CSRNP2Cysteine and serine rich nuclear protein 2. (543 aa)
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1052 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (836 aa)
BOD1L1Uncharacterized protein. (2004 aa)
PPP6R1Protein phosphatase 6 regulatory subunit 1. (855 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1300 aa)
ENSCHIP0000001621414_3_3 domain-containing protein; Belongs to the 14-3-3 family. (217 aa)
SLC9A3R2Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (337 aa)
MTMR3Myotubularin related protein 3. (1219 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (821 aa)
ROS1Tyrosine-protein kinase receptor. (2319 aa)
SMTNL2Smoothelin like 2. (458 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
ENSCHIP00000015156Uncharacterized protein. (101 aa)
LOC102171800Uncharacterized protein. (286 aa)
RACK1Receptor for activated C kinase 1. (317 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
BADBCL2 associated agonist of cell death. (198 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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