STRINGSTRING
LHX1 LHX1 SUFU SUFU VLDLR VLDLR CLN8 CLN8 ENSCHIP00000000097 ENSCHIP00000000097 GDF11 GDF11 SCYL1 SCYL1 SCYL3 SCYL3 HOXC10 HOXC10 OLIG2 OLIG2 SOX12 SOX12 FOXB1 FOXB1 NOG NOG OLIG3 OLIG3 NF1 NF1 TBX20 TBX20 GDF7 GDF7 CHRD CHRD HOXD10 HOXD10 TCTN1 TCTN1 SOX13 SOX13 ABT1 ABT1 DMRT3 DMRT3 ASCL1 ASCL1 SOX4 SOX4 VIT VIT PTCH1 PTCH1 MNX1 MNX1 ZPR1 ZPR1 DAAM2 DAAM2 GLI3 GLI3 DLL4 DLL4 HOXB8 HOXB8 ISL2 ISL2 DRGX DRGX WNT3A WNT3A RELN RELN PKD1 PKD1 LHX4 LHX4 GSX2 GSX2 PHOX2A PHOX2A ADARB1 ADARB1 PHGDH PHGDH WNT1 WNT1 PBX3 PBX3 GBX1 GBX1 PKD2 PKD2 DLL1 DLL1 INTU INTU SHH SHH PAX6 PAX6 DBX1 DBX1 GDNF GDNF SMO SMO LOXL3 LOXL3 PLXDC2 PLXDC2 LRP8 LRP8 ERCC2 ERCC2 LHX5 LHX5 RFX4 RFX4 ISL1 ISL1 DRAXIN DRAXIN PTPRS PTPRS MED12 MED12 TULP3 TULP3 GSX1 GSX1 VSTM5 VSTM5 NKX2-2 NKX2-2 DCC DCC LHX3 LHX3 DCTN1 DCTN1 FOXN4 FOXN4 LBX1 LBX1 TAL1 TAL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LHX1LIM homeobox 1. (406 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
VLDLRVery low density lipoprotein receptor. (873 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (338 aa)
ENSCHIP00000000097Med12-PQL domain-containing protein. (315 aa)
GDF11Growth differentiation factor 11. (406 aa)
SCYL1SCY1 like pseudokinase 1. (807 aa)
SCYL3SCY1 like pseudokinase 3. (734 aa)
HOXC10Homeobox C10. (342 aa)
OLIG2Oligodendrocyte transcription factor 2. (329 aa)
SOX12Transcription factor SOX. (314 aa)
FOXB1Forkhead box B1. (325 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
NF1Neurofibromin 1. (2848 aa)
TBX20T-box transcription factor 20. (449 aa)
GDF7Growth differentiation factor 7. (451 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (957 aa)
HOXD10Homeobox D10. (340 aa)
TCTN1Tectonic family member 1. (592 aa)
SOX13SRY-box transcription factor 13. (592 aa)
ABT1Activator of basal transcription 1. (275 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (472 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (219 aa)
SOX4SRY-box transcription factor 4. (504 aa)
VITVitrin. (652 aa)
PTCH1Patched 1. (1453 aa)
MNX1Motor neuron and pancreas homeobox 1. (411 aa)
ZPR1ZPR1 zinc finger. (459 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1087 aa)
GLI3GLI family zinc finger 3. (1614 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (701 aa)
HOXB8Homeobox B8. (243 aa)
ISL2ISL LIM homeobox 2. (359 aa)
DRGXDorsal root ganglia homeobox. (263 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
RELNReelin. (3469 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4303 aa)
LHX4LIM homeobox 4. (390 aa)
GSX2GS homeobox 2. (305 aa)
PHOX2APaired like homeobox 2A. (284 aa)
ADARB1Adenosine deaminase RNA specific B1. (701 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PBX3PBX homeobox 3. (434 aa)
GBX1Gastrulation brain homeobox 1. (413 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (978 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
INTUInturned planar cell polarity protein. (974 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
PAX6Paired box 6. (486 aa)
DBX1Developing brain homeobox 1. (345 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
LOXL3Lysyl oxidase like 3. (752 aa)
PLXDC2Plexin domain containing 2. (529 aa)
LRP8LDL receptor related protein 8. (1011 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
LHX5LIM homeobox 5. (402 aa)
RFX4Regulatory factor X4. (745 aa)
ISL1ISL LIM homeobox 1. (349 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (346 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1926 aa)
MED12Med12 domain-containing protein. (2040 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (488 aa)
GSX1GS homeobox 1. (266 aa)
VSTM5V-set and transmembrane domain containing 5. (229 aa)
NKX2-2NK2 homeobox 2. (273 aa)
DCCDCC netrin 1 receptor. (1394 aa)
LHX3LIM homeobox 3. (403 aa)
DCTN1CAP-Gly domain-containing protein. (1262 aa)
FOXN4Forkhead box N4. (518 aa)
LBX1Ladybird homeobox 1. (281 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (328 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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