STRINGSTRING
PTCH1 PTCH1 SUFU SUFU CLN8 CLN8 GBX1 GBX1 PHOX2A PHOX2A LHX4 LHX4 ISL2 ISL2 GLI3 GLI3 MNX1 MNX1 SHH SHH LBX1 LBX1 LHX3 LHX3 NKX2-2 NKX2-2 SCYL1 SCYL1 SCYL3 SCYL3 HOXC10 HOXC10 OLIG2 OLIG2 OLIG3 OLIG3 TBX20 TBX20 HOXD10 HOXD10 TCTN1 TCTN1 ABT1 ABT1 ISL1 ISL1 SOX4 SOX4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTCH1Patched 1. (1453 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (338 aa)
GBX1Gastrulation brain homeobox 1. (413 aa)
PHOX2APaired like homeobox 2A. (284 aa)
LHX4LIM homeobox 4. (390 aa)
ISL2ISL LIM homeobox 2. (359 aa)
GLI3GLI family zinc finger 3. (1614 aa)
MNX1Motor neuron and pancreas homeobox 1. (411 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
LBX1Ladybird homeobox 1. (281 aa)
LHX3LIM homeobox 3. (403 aa)
NKX2-2NK2 homeobox 2. (273 aa)
SCYL1SCY1 like pseudokinase 1. (807 aa)
SCYL3SCY1 like pseudokinase 3. (734 aa)
HOXC10Homeobox C10. (342 aa)
OLIG2Oligodendrocyte transcription factor 2. (329 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
TBX20T-box transcription factor 20. (449 aa)
HOXD10Homeobox D10. (340 aa)
TCTN1Tectonic family member 1. (592 aa)
ABT1Activator of basal transcription 1. (275 aa)
ISL1ISL LIM homeobox 1. (349 aa)
SOX4SRY-box transcription factor 4. (504 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.