(17 nodes) Melanocyte differentiation network (Capra hircus)

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Your Input:
	BCL2	BH4_2 domain-containing protein. (229 aa)
	ADAMTS20	ADAM metallopeptidase with thrombospondin type 1 motif 20. (1939 aa)
	TYRP1	Uncharacterized protein. (537 aa)
	OCA2	OCA2 melanosomal transmembrane protein. (838 aa)
	ENPP1	Ectonucleotide pyrophosphatase/phosphodiesterase 1. (818 aa)
	MREG	Melanoregulin. (214 aa)
	KIT	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (974 aa)
	MITF	Melanocyte inducing transcription factor. (519 aa)
	BLOC1S6	Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (172 aa)
	SOX10	SRY-box transcription factor 10. (469 aa)
	MEF2C	MADS-box domain-containing protein. (441 aa)
	GLI3	GLI family zinc finger 3. (1614 aa)
	SLC24A5	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (501 aa)
	LRMDA	Leucine rich melanocyte differentiation associated. (191 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (441 aa)
	OR51E2	Olfactory receptor. (320 aa)
	HPS6	Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (801 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS20	OCA2	ENSCHIP00000033564	ENSCHIP00000030695	ADAM metallopeptidase with thrombospondin type 1 motif 20.	OCA2 melanosomal transmembrane protein.	0.437
BCL2	KIT	ENSCHIP00000015831	ENSCHIP00000025751	BH4_2 domain-containing protein.	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	0.564
BCL2	MITF	ENSCHIP00000015831	ENSCHIP00000025267	BH4_2 domain-containing protein.	Melanocyte inducing transcription factor.	0.427
BLOC1S6	HPS6	ENSCHIP00000024585	ENSCHIP00000001319	Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...]	Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.	0.886
EDNRB	KIT	ENSCHIP00000008345	ENSCHIP00000025751	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	0.792
EDNRB	MITF	ENSCHIP00000008345	ENSCHIP00000025267	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	Melanocyte inducing transcription factor.	0.723
EDNRB	OCA2	ENSCHIP00000008345	ENSCHIP00000030695	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	OCA2 melanosomal transmembrane protein.	0.478
EDNRB	SLC24A5	ENSCHIP00000008345	ENSCHIP00000010034	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.566
EDNRB	SOX10	ENSCHIP00000008345	ENSCHIP00000022016	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	SRY-box transcription factor 10.	0.774
EDNRB	TYRP1	ENSCHIP00000008345	ENSCHIP00000032216	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.680
HPS6	BLOC1S6	ENSCHIP00000001319	ENSCHIP00000024585	Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.	Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...]	0.886
HPS6	TYRP1	ENSCHIP00000001319	ENSCHIP00000032216	Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.	Uncharacterized protein.	0.508
KIT	BCL2	ENSCHIP00000025751	ENSCHIP00000015831	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	BH4_2 domain-containing protein.	0.564
KIT	EDNRB	ENSCHIP00000025751	ENSCHIP00000008345	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	0.792
KIT	MITF	ENSCHIP00000025751	ENSCHIP00000025267	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	Melanocyte inducing transcription factor.	0.734
KIT	SLC24A5	ENSCHIP00000025751	ENSCHIP00000010034	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.570
KIT	SOX10	ENSCHIP00000025751	ENSCHIP00000022016	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	SRY-box transcription factor 10.	0.411
KIT	TYRP1	ENSCHIP00000025751	ENSCHIP00000032216	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	Uncharacterized protein.	0.778
LRMDA	OCA2	ENSCHIP00000008854	ENSCHIP00000030695	Leucine rich melanocyte differentiation associated.	OCA2 melanosomal transmembrane protein.	0.448
MITF	BCL2	ENSCHIP00000025267	ENSCHIP00000015831	Melanocyte inducing transcription factor.	BH4_2 domain-containing protein.	0.427