29 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (456 aa)
	BCL3	BCL3 transcription coactivator. (454 aa)
	NDRG1	N-myc downstream regulated 1. (384 aa)
	GML	UPAR/Ly6 domain-containing protein. (154 aa)
	KAT5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
	TFAP4	Transcription factor AP-4. (335 aa)
	ATRX	ATRX chromatin remodeler. (2105 aa)
	RPS6KA6	Non-specific serine/threonine protein kinase. (644 aa)
	BATF	Basic leucine zipper ATF-like transcription factor. (125 aa)
	PML	Promyelocytic leukemia. (868 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (161 aa)
	ENSCHIP00000000726	Protein kinase domain-containing protein. (176 aa)
	ACER2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
	E2F7	E2F transcription factor 7. (911 aa)
	CHEK2	Checkpoint kinase 2. (534 aa)
	SESN2	Sestrin 2. (471 aa)
	PPM1D	Protein phosphatase, Mg2+/Mn2+ dependent 1D. (605 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	FOXM1	Fork-head domain-containing protein. (763 aa)
	USP10	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (798 aa)
	MUC1	SEA domain-containing protein. (578 aa)
	BRCA2	BRCA2 DNA repair associated. (3405 aa)
	HIPK2	Homeodomain interacting protein kinase 2. (1228 aa)
	PIDD1	P53-induced death domain protein 1. (913 aa)
	ENSCHIP00000022790	UCH domain-containing protein. (675 aa)
	PAXIP1	PAX interacting protein 1. (1006 aa)
	MYO6	Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1289 aa)
	FOXO3	Forkhead box O3. (672 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATRX	BRCA2	ENSCHIP00000011584	ENSCHIP00000024039	ATRX chromatin remodeler.	BRCA2 DNA repair associated.	0.579
ATRX	CHEK2	ENSCHIP00000011584	ENSCHIP00000027824	ATRX chromatin remodeler.	Checkpoint kinase 2.	0.447
ATRX	TP53	ENSCHIP00000011584	ENSCHIP00000030141	ATRX chromatin remodeler.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.832
BRCA2	ATRX	ENSCHIP00000024039	ENSCHIP00000011584	BRCA2 DNA repair associated.	ATRX chromatin remodeler.	0.579
BRCA2	CHEK2	ENSCHIP00000024039	ENSCHIP00000027824	BRCA2 DNA repair associated.	Checkpoint kinase 2.	0.927
BRCA2	FOXM1	ENSCHIP00000024039	ENSCHIP00000030834	BRCA2 DNA repair associated.	Fork-head domain-containing protein.	0.410
BRCA2	KAT5	ENSCHIP00000024039	ENSCHIP00000014439	BRCA2 DNA repair associated.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.437
BRCA2	MUC1	ENSCHIP00000024039	ENSCHIP00000025455	BRCA2 DNA repair associated.	SEA domain-containing protein.	0.449
BRCA2	PAXIP1	ENSCHIP00000024039	ENSCHIP00000022290	BRCA2 DNA repair associated.	PAX interacting protein 1.	0.435
BRCA2	TP53	ENSCHIP00000024039	ENSCHIP00000030141	BRCA2 DNA repair associated.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.951
CASP2	CRADD	ENSCHIP00000018562	ENSCHIP00000027459	Caspase 2; Belongs to the peptidase C14A family.	CASP2 and RIPK1 domain containing adaptor with death domain.	0.966
CASP2	PIDD1	ENSCHIP00000018562	ENSCHIP00000023138	Caspase 2; Belongs to the peptidase C14A family.	P53-induced death domain protein 1.	0.940
CASP2	TP53	ENSCHIP00000018562	ENSCHIP00000030141	Caspase 2; Belongs to the peptidase C14A family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.742
CDKN1A	CHEK2	ENSCHIP00000002564	ENSCHIP00000027824	Cyclin dependent kinase inhibitor 1A.	Checkpoint kinase 2.	0.532
CDKN1A	FOXM1	ENSCHIP00000002564	ENSCHIP00000030834	Cyclin dependent kinase inhibitor 1A.	Fork-head domain-containing protein.	0.434
CDKN1A	FOXO3	ENSCHIP00000002564	ENSCHIP00000019148	Cyclin dependent kinase inhibitor 1A.	Forkhead box O3.	0.778
CDKN1A	PIDD1	ENSCHIP00000002564	ENSCHIP00000023138	Cyclin dependent kinase inhibitor 1A.	P53-induced death domain protein 1.	0.401
CDKN1A	PPM1D	ENSCHIP00000002564	ENSCHIP00000028114	Cyclin dependent kinase inhibitor 1A.	Protein phosphatase, Mg2+/Mn2+ dependent 1D.	0.405
CDKN1A	SESN2	ENSCHIP00000002564	ENSCHIP00000028035	Cyclin dependent kinase inhibitor 1A.	Sestrin 2.	0.478
CDKN1A	TFAP4	ENSCHIP00000002564	ENSCHIP00000012761	Cyclin dependent kinase inhibitor 1A.	Transcription factor AP-4.	0.906