STRINGSTRING
TGFB1 TGFB1 LOC102183132 LOC102183132 NODAL NODAL BMPR1A BMPR1A TGFB3 TGFB3 ZNF8 ZNF8 CCDC142 CCDC142 LOC102171583 LOC102171583 USP15 USP15 DLX5 DLX5 EXT1 EXT1 NOG NOG BMP7 BMP7 FAM83G FAM83G HJV HJV BMP5 BMP5 HFE HFE LOC102183990 LOC102183990 DLX3 DLX3 SMAD1 SMAD1 GDF7 GDF7 CHRD CHRD ATF2 ATF2 GDF3 GDF3 DDX5 DDX5 NANOG NANOG SOSTDC1 SOSTDC1 GDF5 GDF5 SMAD6 SMAD6 TMEM100 TMEM100 BMP2 BMP2 ACVR2A ACVR2A SLC33A1 SLC33A1 SMAD3 SMAD3 LOC108634550 LOC108634550 MSX1 MSX1 SFRP1 SFRP1 RGMA RGMA SMAD5 SMAD5 MEGF8 MEGF8 COMP COMP TGFBR3 TGFBR3 RUNX2 RUNX2 MAPK3 MAPK3 WNT5A WNT5A FST FST HIVEP1 HIVEP1 SMAD9 SMAD9 LOC102183441 LOC102183441 BMPR1B BMPR1B SMURF1 SMURF1 HES1 HES1 GDF2 GDF2 BMPER BMPER SMAD4 SMAD4 SMAD7 SMAD7 GDF6 GDF6 SOST SOST SMPD3 SMPD3 SMAD2 SMAD2 BMPR2 BMPR2 TMPRSS6 TMPRSS6 BMP8A BMP8A BMP4 BMP4 ABL1 ABL1 HES5 HES5 USP9X USP9X SLC39A5 SLC39A5 PDCD4 PDCD4 RGMB RGMB NOTCH2 NOTCH2 ACVR1 ACVR1 TGFB2 TGFB2 EGR1 EGR1 SFRP2 SFRP2 SPART SPART DSG4 DSG4 ETV2 ETV2 BMP8B BMP8B LEF1 LEF1 BMP10 BMP10 TWSG1 TWSG1 ZNF831 ZNF831 BMP6 BMP6 GDF1 GDF1 ACVRL1 ACVRL1 GDF15 GDF15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
LOC102183132VWFC domain-containing protein. (193 aa)
NODALNodal growth differentiation factor. (346 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
ZNF8Zinc finger protein 8. (558 aa)
CCDC142Coiled-coil domain containing 142. (725 aa)
LOC102171583Zinc finger CCHC-type containing 12. (401 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
DLX5Distal-less homeobox 5. (289 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (446 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
FAM83GFamily with sequence similarity 83 member G. (817 aa)
HJVHemojuvelin BMP co-receptor. (427 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (356 aa)
LOC102183990Left-right determination factor. (367 aa)
DLX3Distal-less homeobox 3. (287 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
GDF7Growth differentiation factor 7. (451 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (957 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
GDF3Growth differentiation factor 3. (364 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (622 aa)
NANOGHomeobox domain-containing protein. (300 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
GDF5Growth differentiation factor 5. (499 aa)
SMAD6Mothers against decapentaplegic homolog. (497 aa)
TMEM100Transmembrane protein 100. (134 aa)
BMP2TGF_BETA_2 domain-containing protein. (381 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
SLC33A1Solute carrier family 33 member 1. (550 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
LOC108634550USP domain-containing protein; Belongs to the peptidase C19 family. (2572 aa)
MSX1Msh homeobox 1. (303 aa)
SFRP1Secreted frizzled related protein 1. (308 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (461 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
MEGF8Multiple EGF like domains 8. (2836 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
TGFBR3Transforming growth factor beta receptor 3. (859 aa)
RUNX2RUNX family transcription factor 2. (585 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
FSTUncharacterized protein. (344 aa)
HIVEP1Human immunodeficiency virus type I enhancer binding protein 1. (2675 aa)
SMAD9Mothers against decapentaplegic homolog. (461 aa)
LOC102183441Left-right determination factor. (367 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (558 aa)
SMURF1E3 ubiquitin-protein ligase. (731 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
GDF2Growth differentiation factor 2. (430 aa)
BMPERBMP binding endothelial regulator. (685 aa)
SMAD4Mothers against decapentaplegic homolog. (513 aa)
SMAD7Mothers against decapentaplegic homolog. (427 aa)
GDF6Growth differentiation factor 6. (463 aa)
SOSTSclerostin. (212 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (816 aa)
BMP8ATGF_BETA_2 domain-containing protein. (405 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2570 aa)
SLC39A5Solute carrier family 39 member 5. (541 aa)
PDCD4Programmed cell death 4. (513 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (481 aa)
NOTCH2Notch receptor 2. (2471 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
SPARTSpartin. (668 aa)
DSG4Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1040 aa)
ETV2ETS domain-containing protein. (153 aa)
BMP8BTGF_BETA_2 domain-containing protein. (405 aa)
LEF1HMG box domain-containing protein. (430 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
ZNF831Zinc finger protein 831. (1600 aa)
BMP6Bone morphogenetic protein 6. (496 aa)
GDF1TGF_BETA_2 domain-containing protein. (368 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
GDF15Growth differentiation factor 15. (308 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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