STRINGSTRING
TESC TESC LEF1 LEF1 TRIB1 TRIB1 HAX1 HAX1 INPP5D INPP5D RUNX1 RUNX1 RARA RARA EVI2B EVI2B HCLS1 HCLS1 ADIPOQ ADIPOQ ZBTB46 ZBTB46 C1QC C1QC CUL4A CUL4A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TESCTescalcin. (214 aa)
LEF1HMG box domain-containing protein. (430 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1202 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (453 aa)
RARARetinoic acid receptor alpha. (462 aa)
EVI2BEcotropic viral integration site 2B. (456 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (471 aa)
ADIPOQC1q domain-containing protein. (283 aa)
ZBTB46Zinc finger and BTB domain containing 46. (589 aa)
C1QCComplement C1q C chain. (244 aa)
CUL4ACullin 4A; Belongs to the cullin family. (764 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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