36 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SIX2	SIX homeobox 2. (296 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (681 aa)
	HOXA7	Homeobox A7. (239 aa)
	HES5	Hes family bHLH transcription factor 5. (165 aa)
	SOX9	SRY-box transcription factor 9. (525 aa)
	FRZB	Frizzled related protein. (325 aa)
	NOTCH1	Notch receptor 1. (2508 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	FOXJ2	Forkhead box J2. (561 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
	OSR1	Odd-skipped related transcription factor 1. (267 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	GRHL2	Grainyhead like transcription factor 2. (622 aa)
	XDH	FAD-binding PCMH-type domain-containing protein. (1331 aa)
	YAP1	Yes associated protein 1. (503 aa)
	MMP9	Uncharacterized protein. (709 aa)
	FST	Uncharacterized protein. (344 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1127 aa)
	SRSF6	Uncharacterized protein. (345 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	TBX3	T-box transcription factor 3. (749 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (433 aa)
	VHL	Uncharacterized protein. (181 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
	S1PR3	Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	NODAL	Nodal growth differentiation factor. (346 aa)
	NKX6-3	Homeobox domain-containing protein. (263 aa)
	FOXE3	Forkhead box E3. (315 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (315 aa)
	ENSCHIP00000005003	Uncharacterized protein. (345 aa)
	ACVRL1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVRL1	SPRY2	ENSCHIP00000033488	ENSCHIP00000004142	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Sprouty RTK signaling antagonist 2.	0.412
CAV1	CCND1	ENSCHIP00000020742	ENSCHIP00000006815	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Cyclin D1; Belongs to the cyclin family.	0.494
CAV1	CTNNB1	ENSCHIP00000020742	ENSCHIP00000031016	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Catenin beta 1.	0.883
CAV1	KRAS	ENSCHIP00000020742	ENSCHIP00000032733	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	KRAS proto-oncogene, GTPase.	0.438
CAV1	MMP9	ENSCHIP00000020742	ENSCHIP00000016938	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein.	0.495
CAV1	SPRED1	ENSCHIP00000020742	ENSCHIP00000007888	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Sprouty related EVH1 domain containing 1.	0.447
CCND1	CAV1	ENSCHIP00000006815	ENSCHIP00000020742	Cyclin D1; Belongs to the cyclin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.494
CCND1	CTNNB1	ENSCHIP00000006815	ENSCHIP00000031016	Cyclin D1; Belongs to the cyclin family.	Catenin beta 1.	0.934
CCND1	EZH2	ENSCHIP00000006815	ENSCHIP00000003420	Cyclin D1; Belongs to the cyclin family.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.611
CCND1	JAG1	ENSCHIP00000006815	ENSCHIP00000023437	Cyclin D1; Belongs to the cyclin family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.705
CCND1	KRAS	ENSCHIP00000006815	ENSCHIP00000032733	Cyclin D1; Belongs to the cyclin family.	KRAS proto-oncogene, GTPase.	0.758
CCND1	MMP9	ENSCHIP00000006815	ENSCHIP00000016938	Cyclin D1; Belongs to the cyclin family.	Uncharacterized protein.	0.845
CCND1	NOTCH1	ENSCHIP00000006815	ENSCHIP00000023681	Cyclin D1; Belongs to the cyclin family.	Notch receptor 1.	0.822
CCND1	SMO	ENSCHIP00000006815	ENSCHIP00000027079	Cyclin D1; Belongs to the cyclin family.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.601
CCND1	SOX9	ENSCHIP00000006815	ENSCHIP00000024523	Cyclin D1; Belongs to the cyclin family.	SRY-box transcription factor 9.	0.628
CCND1	YAP1	ENSCHIP00000006815	ENSCHIP00000017099	Cyclin D1; Belongs to the cyclin family.	Yes associated protein 1.	0.538
CCND1	ZEB1	ENSCHIP00000006815	ENSCHIP00000015942	Cyclin D1; Belongs to the cyclin family.	Zinc finger E-box binding homeobox 1.	0.679
CTNNB1	CAV1	ENSCHIP00000031016	ENSCHIP00000020742	Catenin beta 1.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.883
CTNNB1	CCND1	ENSCHIP00000031016	ENSCHIP00000006815	Catenin beta 1.	Cyclin D1; Belongs to the cyclin family.	0.934
CTNNB1	DLL1	ENSCHIP00000031016	ENSCHIP00000023056	Catenin beta 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.585