(23 nodes) Polarized epithelial cell differentiation network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DLG5	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1946 aa)
	CAMSAP3	Calmodulin regulated spectrin associated protein family member 3. (1246 aa)
	LOC102176514	Uncharacterized protein. (182 aa)
	ZDHHC7	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (443 aa)
	SLC9A3R1	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (386 aa)
	IFT20	Intraflagellar transport 20. (156 aa)
	MYO9A	Myosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2630 aa)
	MSN	Moesin. (666 aa)
	ENSCHIP00000011371	Uncharacterized protein. (193 aa)
	RHOA	Ras-like protein family member A. (193 aa)
	CDC42	Uncharacterized protein. (191 aa)
	SH3BP1	Uncharacterized protein. (601 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	TTC8	Tetratricopeptide repeat domain 8. (511 aa)
	FAT1	FAT atypical cadherin 1. (4643 aa)
	TCF15	Transcription factor 15. (197 aa)
	FOXF1	Forkhead box F1. (391 aa)
	SCRIB	Scribble planar cell polarity protein. (1582 aa)
	OPHN1	Oligophrenin 1. (436 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
	LRRC1	Leucine rich repeat containing 1. (517 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (681 aa)
	SYNE4	KASH domain-containing protein. (284 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	DLG5	ENSCHIP00000012064	ENSCHIP00000000553	Uncharacterized protein.	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family.	0.460
CDC42	ENSCHIP00000011371	ENSCHIP00000012064	ENSCHIP00000011371	Uncharacterized protein.	Uncharacterized protein.	0.437
CDC42	MSN	ENSCHIP00000012064	ENSCHIP00000010531	Uncharacterized protein.	Moesin.	0.780
CDC42	MYO9A	ENSCHIP00000012064	ENSCHIP00000008521	Uncharacterized protein.	Myosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.757
CDC42	OPHN1	ENSCHIP00000012064	ENSCHIP00000021448	Uncharacterized protein.	Oligophrenin 1.	0.682
CDC42	RHOA	ENSCHIP00000012064	ENSCHIP00000011951	Uncharacterized protein.	Ras-like protein family member A.	0.963
CDC42	SCRIB	ENSCHIP00000012064	ENSCHIP00000020687	Uncharacterized protein.	Scribble planar cell polarity protein.	0.610
CDC42	SLC9A3R1	ENSCHIP00000012064	ENSCHIP00000007323	Uncharacterized protein.	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.	0.410
DLG5	CDC42	ENSCHIP00000000553	ENSCHIP00000012064	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family.	Uncharacterized protein.	0.460
DLG5	MYO9A	ENSCHIP00000000553	ENSCHIP00000008521	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family.	Myosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.761
ENSCHIP00000011371	CDC42	ENSCHIP00000011371	ENSCHIP00000012064	Uncharacterized protein.	Uncharacterized protein.	0.437
ENSCHIP00000011371	LOC102176514	ENSCHIP00000011371	ENSCHIP00000004889	Uncharacterized protein.	Uncharacterized protein.	0.436
ENSCHIP00000011371	MYO9A	ENSCHIP00000011371	ENSCHIP00000008521	Uncharacterized protein.	Myosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.705
LOC102176514	ENSCHIP00000011371	ENSCHIP00000004889	ENSCHIP00000011371	Uncharacterized protein.	Uncharacterized protein.	0.436
LOC102176514	MYO9A	ENSCHIP00000004889	ENSCHIP00000008521	Uncharacterized protein.	Myosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.709
LOC102176514	RHOA	ENSCHIP00000004889	ENSCHIP00000011951	Uncharacterized protein.	Ras-like protein family member A.	0.436
MSN	CDC42	ENSCHIP00000010531	ENSCHIP00000012064	Moesin.	Uncharacterized protein.	0.780
MSN	RHOA	ENSCHIP00000010531	ENSCHIP00000011951	Moesin.	Ras-like protein family member A.	0.888
MSN	SLC9A3R1	ENSCHIP00000010531	ENSCHIP00000007323	Moesin.	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.	0.994
MYO9A	CDC42	ENSCHIP00000008521	ENSCHIP00000012064	Myosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Uncharacterized protein.	0.757