STRINGSTRING
NHLH1 NHLH1 LOC102175122 LOC102175122 ENSCHIP00000000779 ENSCHIP00000000779 POU4F1 POU4F1 NANOS1 NANOS1 CDK5R1 CDK5R1 CRKL CRKL OGDH OGDH NHLH2 NHLH2 GLI1 GLI1 EZH2 EZH2 NEUROD2 NEUROD2 B4GALT2 B4GALT2 LOC102185836 LOC102185836 CRK CRK NOG NOG BMP7 BMP7 SEZ6 SEZ6 CBS CBS TRNP1 TRNP1 ITGB1 ITGB1 SMAD1 SMAD1 KLHL4 KLHL4 KCNE1 KCNE1 ATF2 ATF2 SKOR2 SKOR2 ZNF423 ZNF423 PTPRS PTPRS TTC21B TTC21B ATRN ATRN FZD4 FZD4 GBA GBA ARCN1 ARCN1 ALDH1A2 ALDH1A2 CDK5 CDK5 HOXB2 HOXB2 SPTBN2 SPTBN2 RORA RORA NAGLU NAGLU CTNNB1 CTNNB1 AHI1 AHI1 LEF1 LEF1 HSPA5 HSPA5 TP53 TP53 RERE RERE KLHL5-2 KLHL5-2 WHRN WHRN SEZ6L2 SEZ6L2 HOXA2 HOXA2 ZNF365 ZNF365 PTF1A PTF1A SHH SHH CLP1 CLP1 SMO SMO MECP2 MECP2 LHX5 LHX5 WNT7A WNT7A LMX1A LMX1A ATP1B2 ATP1B2 CPLANE1 CPLANE1 LHX1 LHX1 KDM2B KDM2B ABL1 ABL1 PROX1 PROX1 TMBIM7P TMBIM7P KLHL1 KLHL1 MAP2K1 MAP2K1 KAT2A KAT2A LRRC1 LRRC1 CEND1 CEND1 DLL1 DLL1 XRCC1 XRCC1 GRID2 GRID2 OPHN1 OPHN1 KIF14 KIF14 PTPN11 PTPN11 SCRIB SCRIB FAIM2 FAIM2 PLXNA2 PLXNA2 WNT1 WNT1 EGR2 EGR2 SEC24B SEC24B FGF2 FGF2 ENSCHIP00000018749 ENSCHIP00000018749 OTX1 OTX1 TBR1 TBR1 LDB1 LDB1 NFIB NFIB KLHL5 KLHL5 CDK5R2 CDK5R2 GNPAT GNPAT COQ8B COQ8B MAFB MAFB ASCL1 ASCL1 NEUROD1 NEUROD1 HOXB3 HOXB3 RBFOX2 RBFOX2 AGTPBP1 AGTPBP1 PDSS2 PDSS2 TTLL1 TTLL1 HES1 HES1 PHOX2A PHOX2A HOXB1 HOXB1 GSX2 GSX2 PHOX2B PHOX2B SEMA4C SEMA4C EN1 EN1 ATF5 ATF5 ARL13B ARL13B AARS1 AARS1 HNF1B HNF1B SERPINE2 SERPINE2 BCL2 BCL2 CNTN1 CNTN1 RPGRIP1L RPGRIP1L CBLN1 CBLN1 EN2 EN2 GBX2 GBX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NHLH1Nescient helix-loop-helix 1. (133 aa)
LOC102175122Uncharacterized protein. (1342 aa)
ENSCHIP00000000779Uncharacterized protein. (79 aa)
POU4F1POU domain protein. (421 aa)
NANOS1Nanos C2HC-type zinc finger 1; Belongs to the nanos family. (292 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
CRKLCRK like proto-oncogene, adaptor protein. (302 aa)
OGDHOxoglutarate dehydrogenase. (1038 aa)
NHLH2Nescient helix-loop-helix 2. (133 aa)
GLI1GLI family zinc finger 1. (1105 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
NEUROD2Neurogenic differentiation factor. (382 aa)
B4GALT2Beta-1,4-galactosyltransferase 2. (369 aa)
LOC102185836Uncharacterized protein. (1256 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SEZ6Seizure related 6 homolog. (979 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (586 aa)
TRNP1TMF1 regulated nuclear protein 1. (219 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
KLHL4Kelch like family member 4. (717 aa)
KCNE1Uncharacterized protein. (129 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
SKOR2SKI family transcriptional corepressor 2. (998 aa)
ZNF423Zinc finger protein 423. (1308 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1926 aa)
TTC21BTetratricopeptide repeat domain 21B. (1326 aa)
ATRNAttractin. (1415 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (555 aa)
GBAGlucosylceramidase. (536 aa)
ARCN1Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (510 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
HOXB2Homeobox B2. (354 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2392 aa)
RORAUncharacterized protein. (527 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (741 aa)
CTNNB1Catenin beta 1. (781 aa)
AHI1Abelson helper integration site 1. (1194 aa)
LEF1HMG box domain-containing protein. (430 aa)
HSPA5Heat shock 70kDa protein 5; Belongs to the heat shock protein 70 family. (655 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
REREArginine-glutamic acid dipeptide repeats. (1621 aa)
KLHL5-2BTB domain-containing protein. (295 aa)
WHRNWhirlin. (918 aa)
SEZ6L2Seizure related 6 homolog like 2. (923 aa)
HOXA2Homeobox A2. (372 aa)
ZNF365Zinc finger protein 365. (406 aa)
PTF1APancreas associated transcription factor 1a. (325 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
CLP1Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (425 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (481 aa)
LHX5LIM homeobox 5. (402 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
LMX1ALIM homeobox transcription factor 1 alpha. (382 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
CPLANE1Ciliogenesis and planar polarity effector 1. (3120 aa)
LHX1LIM homeobox 1. (406 aa)
KDM2BLysine demethylase 2B. (1309 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
PROX1Prospero homeobox 1. (734 aa)
TMBIM7PUncharacterized protein; Belongs to the BI1 family. (294 aa)
KLHL1Kelch like family member 1. (631 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (397 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
LRRC1Leucine rich repeat containing 1. (517 aa)
CEND1Cell cycle exit and neuronal differentiation 1. (139 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
XRCC1X-ray repair cross complementing 1. (632 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (922 aa)
OPHN1Oligophrenin 1. (436 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1643 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
SCRIBScribble planar cell polarity protein. (1582 aa)
FAIM2Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (316 aa)
PLXNA2Plexin A2. (1894 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
EGR2Early growth response 2. (472 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1261 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
ENSCHIP00000018749Uncharacterized protein. (1317 aa)
OTX1Orthodenticle homeobox 1. (355 aa)
TBR1T-box brain transcription factor 1. (682 aa)
LDB1LIM domain binding 1. (411 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
KLHL5Uncharacterized protein. (191 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (373 aa)
GNPATDihydroxyacetone phosphate acyltransferase. (680 aa)
COQ8BCoenzyme Q8B. (525 aa)
MAFBMAF bZIP transcription factor B. (329 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (219 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
HOXB3Homeobox B3. (426 aa)
RBFOX2RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events. (446 aa)
AGTPBP1ATP/GTP binding protein 1. (1225 aa)
PDSS2Decaprenyl diphosphate synthase subunit 2; Belongs to the FPP/GGPP synthase family. (412 aa)
TTLL1Tubulin tyrosine ligase like 1. (423 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
PHOX2APaired like homeobox 2A. (284 aa)
HOXB1Homeobox B1. (302 aa)
GSX2GS homeobox 2. (305 aa)
PHOX2BPaired like homeobox 2B. (315 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
EN1Homeobox protein engrailed-like. (402 aa)
ATF5Activating transcription factor 5. (287 aa)
ARL13BADP ribosylation factor like GTPase 13B. (429 aa)
AARS1Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
HNF1BHNF1 homeobox B. (558 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (397 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
CNTN1Contactin 1. (1018 aa)
RPGRIP1LRPGRIP1 like. (1295 aa)
CBLN1Cerebellin 1 precursor. (193 aa)
EN2Homeobox protein engrailed-like. (324 aa)
GBX2Gastrulation brain homeobox 2. (349 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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