STRINGSTRING
GAP43 GAP43 NINJ1 NINJ1 PTGFRN PTGFRN YAP1 YAP1 APOD APOD AURKA AURKA NEFL NEFL PLG PLG WNT10B WNT10B BCL2 BCL2 OMG OMG MAG MAG CCND1 CCND1 BCL9 BCL9 MYOD1 MYOD1 CD81 CD81 TNR TNR CD9 CD9 TM4SF4 TM4SF4 APOA5 APOA5 EZH2 EZH2 GLI1 GLI1 ENSCHIP00000003108 ENSCHIP00000003108 CDKN1A CDKN1A HDGFL2 HDGFL2 NREP NREP BIN3 BIN3 UPF2 UPF2 MUSTN1 MUSTN1 ENSCHIP00000023179 ENSCHIP00000023179 TNC TNC ANXA1 ANXA1 FOLR1 FOLR1 TMEM182 TMEM182 SELENON SELENON WNT7A WNT7A TEC TEC MSTN MSTN SOX15 SOX15 GFAP GFAP MED1 MED1 LGR6 LGR6 FZD9 FZD9 GJA1 GJA1 JUN JUN AKIRIN1 AKIRIN1 GAS6 GAS6 LAMB2 LAMB2 PTPRF PTPRF SGCA SGCA KPNA1 KPNA1 FZD7 FZD7 CEBPB CEBPB TARBP2 TARBP2 ERBB4 ERBB4 MYMK MYMK IGF1 IGF1 SULF2 SULF2 CPQ CPQ TXK TXK KLF5 KLF5 NINJ2 NINJ2 IL6 IL6 IFRD2 IFRD2 PTN PTN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GAP43Growth associated protein 43. (238 aa)
NINJ1Ninjurin 1. (151 aa)
PTGFRNProstaglandin F2 receptor inhibitor. (879 aa)
YAP1Yes associated protein 1. (503 aa)
APODApolipoprotein D. (213 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (405 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (554 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (816 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
OMGOligodendrocyte myelin glycoprotein. (440 aa)
MAGMyelin associated glycoprotein. (626 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
BCL9BCL9 transcription coactivator. (1426 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
CD81Tetraspanin. (236 aa)
TNRTenascin R. (1358 aa)
CD9Tetraspanin. (226 aa)
TM4SF4Transmembrane 4 L six family member 4. (203 aa)
APOA5Apolipoprotein A5. (368 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
GLI1GLI family zinc finger 1. (1105 aa)
ENSCHIP00000003108Uncharacterized protein. (170 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
HDGFL2HDGF like 2. (658 aa)
NREPUncharacterized protein. (67 aa)
BIN3Bridging integrator 3. (253 aa)
UPF2UPF2 regulator of nonsense mediated mRNA decay. (1272 aa)
MUSTN1Uncharacterized protein. (86 aa)
ENSCHIP00000023179Uncharacterized protein. (330 aa)
TNCTenascin C. (2201 aa)
ANXA1Annexin. (346 aa)
FOLR1Folate_rec domain-containing protein. (251 aa)
TMEM182Transmembrane protein 182. (229 aa)
SELENONSelenoprotein N. (579 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
TECTyrosine-protein kinase. (632 aa)
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (375 aa)
SOX15SRY-box transcription factor 15. (233 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (428 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1577 aa)
LGR6Leucine rich repeat containing G protein-coupled receptor 6. (902 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (589 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
AKIRIN1Akirin 1. (192 aa)
GAS6Growth arrest specific 6. (671 aa)
LAMB2Laminin subunit beta 2. (1802 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (1902 aa)
SGCASarcoglycan alpha. (388 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (538 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa)
CEBPBCCAAT/enhancer-binding protein. (307 aa)
TARBP2RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (370 aa)
ERBB4Protein kinase domain-containing protein. (462 aa)
MYMKMyomaker, myoblast fusion factor. (221 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
SULF2Sulfatase 2. (864 aa)
CPQCarboxypeptidase Q. (483 aa)
TXKTyrosine-protein kinase. (527 aa)
KLF5Uncharacterized protein. (454 aa)
NINJ2Ninjurin 2. (143 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
IFRD2Interferon related developmental regulator 2. (442 aa)
PTNPleiotrophin. (183 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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