STRINGSTRING
ENSCHIP00000001931 ENSCHIP00000001931 BAIAP2L1 BAIAP2L1 PAK1 PAK1 ENSCHIP00000001275 ENSCHIP00000001275 TPPP2 TPPP2 IL5 IL5 ARHGEF5 ARHGEF5 ENSCHIP00000000908 ENSCHIP00000000908 ENSCHIP00000000486 ENSCHIP00000000486 ENSCHIP00000030908 ENSCHIP00000030908 SYK SYK VASP VASP TGFB1 TGFB1 TERF1 TERF1 TTBK1 TTBK1 LGALS3 LGALS3 GBP5 GBP5 CDC42EP5 CDC42EP5 WNT10B WNT10B CDC42EP2 CDC42EP2 CCL24 CCL24 NAV3 NAV3 SNCA SNCA RPS3 RPS3 CDH17 CDH17 CDT1 CDT1 NCK1 NCK1 FAM178B FAM178B CCL11 CCL11 TPPP TPPP MSN MSN SLAIN2 SLAIN2 ENSCHIP00000011371 ENSCHIP00000011371 FSCN1 FSCN1 CDK5RAP2 CDK5RAP2 STMP1 STMP1 SNX9 SNX9 RHOA RHOA MAPK9 MAPK9 ESR1 ESR1 BID BID NPHS1 NPHS1 GSK3B GSK3B DHX33 DHX33 SLAIN1 SLAIN1 NEK7 NEK7 CSF3 CSF3 AKAP9 AKAP9 SLF1 SLF1 CDH5 CDH5 RACK1 RACK1 ENSCHIP00000015156 ENSCHIP00000015156 ENSCHIP00000015226 ENSCHIP00000015226 CDKN1B CDKN1B GRB2 GRB2 BAK1 BAK1 TRABD2B TRABD2B FER FER BAX BAX IFNG IFNG RASIP1 RASIP1 ATM ATM CDC42EP1 CDC42EP1 AMBRA1 AMBRA1 ISG15 ISG15 FES FES FERMT1 FERMT1 BAIAP2 BAIAP2 PSMC6 PSMC6 BAIAP2L2 BAIAP2L2 PLCG2 PLCG2 FNIP2 FNIP2 MYD88 MYD88 PLEK PLEK PRKCE PRKCE SPIDR SPIDR VCP VCP CKAP5 CKAP5 TLR4 TLR4 MPP7 MPP7 BRK1 BRK1 CARMIL1 CARMIL1 MTOR MTOR CDC42EP4 CDC42EP4 EVL EVL CRACD CRACD PDE4DIP PDE4DIP NCK2 NCK2 BBC3 BBC3 USP50 USP50 DLG1 DLG1 EIF4G1 EIF4G1 NCKAP1L NCKAP1L ENSCHIP00000005724 ENSCHIP00000005724 ZDHHC1 ZDHHC1 LOC106502311 LOC106502311 BCL2L11 BCL2L11 FCHSD1 FCHSD1 BAG4 BAG4 ABCA3 ABCA3 ASAP1 ASAP1 SLF2 SLF2 ENSCHIP00000023367 ENSCHIP00000023367 FNIP1 FNIP1 PSRC1 PSRC1 ARL2 ARL2 TPPP3 TPPP3 FMN1 FMN1 ENSCHIP00000024183 ENSCHIP00000024183 GIT1 GIT1 ATR ATR PFN2 PFN2 PARK7 PARK7 TLR6 TLR6 CLIP1 CLIP1 MMP3 MMP3 RICTOR RICTOR ATAT1 ATAT1 MECP2 MECP2 PYCARD PYCARD MAPRE1 MAPRE1 CCL26 CCL26 FERMT2 FERMT2 LMOD2 LMOD2 WARS1 WARS1 ICE1 ICE1 RHOC RHOC DCTN1 DCTN1 DLG2 DLG2 MET MET TP53 TP53 HIP1R HIP1R PIH1D1 PIH1D1 CCL21 CCL21 AJUBA AJUBA ENSCHIP00000031771 ENSCHIP00000031771 PTK2B PTK2B SH3GLB1 SH3GLB1 CTTN CTTN SKAP1 SKAP1 NR1H2 NR1H2 TFRC TFRC CSF2 CSF2 CLEC7A CLEC7A VEGFA VEGFA ARF6 ARF6 TNF TNF HRK HRK C15orf62 C15orf62 MED25 MED25 LCP1 LCP1 NUMA1 NUMA1 ENSCHIP00000003472 ENSCHIP00000003472 LMOD1 LMOD1 FCHSD2 FCHSD2 ENSCHIP00000003109 ENSCHIP00000003109 DAB2IP DAB2IP SRC SRC MLST8 MLST8 CDC42EP3 CDC42EP3 CDK5R1 CDK5R1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCHIP00000001931AAA domain-containing protein. (316 aa)
BAIAP2L1BAI1 associated protein 2 like 1. (511 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
ENSCHIP00000001275Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (154 aa)
TPPP2Tubulin polymerization promoting protein family member 2. (171 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (129 aa)
ARHGEF5DH domain-containing protein. (449 aa)
ENSCHIP00000000908Profilin; Belongs to the profilin family. (140 aa)
ENSCHIP00000000486Uncharacterized protein. (144 aa)
ENSCHIP00000030908BAG domain-containing protein. (427 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (383 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (436 aa)
TTBK1Tau tubulin kinase 1. (1311 aa)
LGALS3Galectin. (260 aa)
GBP5Guanylate binding protein 5. (487 aa)
CDC42EP5CDC42 effector protein 5. (153 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
CDC42EP2Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton; Belongs to the BORG/CEP family. (210 aa)
CCL24C-C motif chemokine ligand 24. (116 aa)
NAV3Neuron navigator 3. (2364 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
CDH17Cadherin 17. (832 aa)
CDT1Chromatin licensing and DNA replication factor 1. (637 aa)
NCK1Cytoplasmic protein. (377 aa)
FAM178BFamily with sequence similarity 178 member B. (699 aa)
CCL11C-C motif chemokine. (97 aa)
TPPPTubulin polymerization promoting protein. (221 aa)
MSNMoesin. (666 aa)
SLAIN2SLAIN motif family member 2. (608 aa)
ENSCHIP00000011371Uncharacterized protein. (193 aa)
FSCN1Fascin. (493 aa)
CDK5RAP2CDK5 regulatory subunit associated protein 2. (1870 aa)
STMP1Short transmembrane mitochondrial protein 1. (53 aa)
SNX9Sorting nexin. (593 aa)
RHOARas-like protein family member A. (193 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
BIDUncharacterized protein. (244 aa)
NPHS1NPHS1 adhesion molecule, nephrin. (1233 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
DHX33DEAH-box helicase 33. (698 aa)
SLAIN1SLAIN motif family member 1. (573 aa)
NEK7NIMA related kinase 7; Belongs to the protein kinase superfamily. (302 aa)
CSF3Colony stimulating factor 3. (226 aa)
AKAP9A-kinase anchoring protein 9. (3839 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1056 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
RACK1Receptor for activated C kinase 1. (317 aa)
ENSCHIP00000015156Uncharacterized protein. (101 aa)
ENSCHIP00000015226KH type-2 domain-containing protein. (204 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
TRABD2BTraB domain containing 2B. (521 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (821 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
RASIP1Ras interacting protein 1. (961 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
CDC42EP1CDC42 effector protein 1. (361 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1300 aa)
ISG15Interferon-stimulated protein 17/ubiquitin cross-reactive protein. (157 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (804 aa)
FERMT1Fermitin family member 1. (679 aa)
BAIAP2BAI1 associated protein 2. (535 aa)
PSMC6AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
BAIAP2L2BAI1 associated protein 2 like 2. (522 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
FNIP2Folliculin interacting protein 2. (1104 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
PLEKPleckstrin. (356 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (608 aa)
SPIDRScaffold protein involved in DNA repair. (916 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (816 aa)
CKAP5Cytoskeleton associated protein 5. (2040 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
MPP7Membrane palmitoylated protein 7; Belongs to the MAGUK family. (576 aa)
BRK1Uncharacterized protein. (75 aa)
CARMIL1Capping protein regulator and myosin 1 linker 1. (1421 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
CDC42EP4CDC42 effector protein 4. (348 aa)
EVLEnah/Vasp-like. (490 aa)
CRACDKIAA1211. (1189 aa)
PDE4DIPPhosphodiesterase 4D interacting protein. (2533 aa)
NCK2Cytoplasmic protein. (376 aa)
BBC3Uncharacterized protein. (193 aa)
USP50Ubiquitin specific peptidase 50; Belongs to the peptidase C19 family. (378 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1607 aa)
NCKAP1LNCK associated protein 1 like. (1178 aa)
ENSCHIP00000005724Uncharacterized protein. (62 aa)
ZDHHC1Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (531 aa)
LOC106502311Uncharacterized protein. (148 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (195 aa)
FCHSD1FCH and double SH3 domains 1. (666 aa)
BAG4BAG domain-containing protein. (457 aa)
ABCA3ATP binding cassette subfamily A member 3. (1704 aa)
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 1. (1126 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1167 aa)
ENSCHIP00000023367Calponin-homology (CH) domain-containing protein. (228 aa)
FNIP1Folliculin interacting protein 1. (1162 aa)
PSRC1Proline and serine rich coiled-coil 1. (326 aa)
ARL2ARL2-SNX15 readthrough (NMD candidate); Belongs to the small GTPase superfamily. Arf family. (184 aa)
TPPP3Tubulin polymerization promoting protein family member 3. (176 aa)
FMN1Formin 1. (1435 aa)
ENSCHIP00000024183Uncharacterized protein. (207 aa)
GIT1GIT ArfGAP 1. (738 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
PFN2Profilin; Belongs to the profilin family. (140 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
TLR6Toll-like receptor. (966 aa)
CLIP1CAP-Gly domain containing linker protein 1. (1419 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1707 aa)
ATAT1Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (421 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (481 aa)
PYCARDPYD and CARD domain containing. (196 aa)
MAPRE1Microtubule associated protein RP/EB family member 1. (268 aa)
CCL26C-C motif chemokine. (94 aa)
FERMT2Fermitin family member 2. (680 aa)
LMOD2Leiomodin 2. (554 aa)
WARS1Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (482 aa)
ICE1Interactor of little elongation complex ELL subunit 1. (2161 aa)
RHOCRas homolog family member C. (193 aa)
DCTN1CAP-Gly domain-containing protein. (1262 aa)
DLG2Discs large MAGUK scaffold protein 2. (901 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1384 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
HIP1RHuntingtin interacting protein 1 related. (1115 aa)
PIH1D1PIH1 domain containing 1. (290 aa)
CCL21C-C motif chemokine ligand 21. (131 aa)
AJUBAAjuba LIM protein. (571 aa)
ENSCHIP00000031771C2 domain-containing protein. (204 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (402 aa)
CTTNCortactin. (554 aa)
SKAP1Src kinase associated phosphoprotein 1. (309 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (457 aa)
TFRCTransferrin receptor. (790 aa)
CSF2Granulocyte-macrophage colony stimulating factor. (144 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (214 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
HRKActivator of apoptosis harakiri; Promotes apoptosis. (91 aa)
C15orf62Chromosome 15 open reading frame 62. (176 aa)
MED25Mediator complex subunit 25. (744 aa)
LCP1Lymphocyte cytosolic protein 1. (627 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2115 aa)
ENSCHIP00000003472Uncharacterized protein. (75 aa)
LMOD1Leiomodin 1. (574 aa)
FCHSD2FCH and double SH3 domains 2. (758 aa)
ENSCHIP00000003109WD_REPEATS_REGION domain-containing protein. (59 aa)
DAB2IPDAB2 interacting protein. (1198 aa)
SRCTyrosine-protein kinase. (538 aa)
MLST8MTOR associated protein, LST8 homolog. (338 aa)
CDC42EP3CDC42 effector protein 3. (254 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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