(39 nodes) Positive regulation of telomere maintenance via telomerase network (Capra hircus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	LOC102170672	T-complex protein 1 subunit delta. (529 aa)
	LOC108635607	Uncharacterized protein. (512 aa)
	LOC102175542	Uncharacterized protein. (307 aa)
	PKIB	cAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (79 aa)
	ENSCHIP00000025330	Uncharacterized protein. (484 aa)
	NEK7	NIMA related kinase 7; Belongs to the protein kinase superfamily. (302 aa)
	POT1	Protection of telomeres 1. (785 aa)
	CCT4	T-complex protein 1 subunit delta. (541 aa)
	MAPKAPK5	Protein kinase domain-containing protein. (431 aa)
	ENSCHIP00000002380	Uncharacterized protein. (531 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)
	HMBOX1	Homeobox containing 1. (420 aa)
	XRCC5	X-ray repair cross complementing 5. (736 aa)
	FBXO4	F-box protein 4. (393 aa)
	LOC102189034	Uncharacterized protein. (320 aa)
	CCT3	T-complex protein 1 subunit gamma. (545 aa)
	ENSCHIP00000006258	Uncharacterized protein. (474 aa)
	MAP3K4	Mitogen-activated protein kinase kinase kinase 4. (1590 aa)
	NEK2	NIMA related kinase 2. (445 aa)
	TNKS	Poly [ADP-ribose] polymerase. (1327 aa)
	CCT6A	Uncharacterized protein. (531 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (711 aa)
	CCT2	Chaperonin containing TCP1 subunit 2. (535 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	ACD	ACD shelterin complex subunit and telomerase recruitment factor. (458 aa)
	HNRNPA1	Uncharacterized protein. (320 aa)
	PNKP	Polynucleotide kinase 3'-phosphatase. (522 aa)
	LOC102174357	Uncharacterized protein. (510 aa)
	AURKB	Aurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
	CCT7	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (543 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
	LOC102185345	Uncharacterized protein. (483 aa)
	TCP1	T-complex 1. (556 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
	DKC1	Dyskerin pseudouridine synthase 1. (506 aa)
	ENSCHIP00000018363	Uncharacterized protein. (331 aa)
	PARN	Poly(A)-specific ribonuclease. (638 aa)
	CCT5	Chaperonin containing TCP1 subunit 5. (541 aa)
	ENSCHIP00000022338	Uncharacterized protein. (300 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACD	DKC1	ENSCHIP00000030979	ENSCHIP00000017633	ACD shelterin complex subunit and telomerase recruitment factor.	Dyskerin pseudouridine synthase 1.	0.714
ACD	POT1	ENSCHIP00000030979	ENSCHIP00000013444	ACD shelterin complex subunit and telomerase recruitment factor.	Protection of telomeres 1.	0.997
ATM	CTNNB1	ENSCHIP00000016363	ENSCHIP00000031016	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Catenin beta 1.	0.528
ATM	NEK2	ENSCHIP00000016363	ENSCHIP00000005351	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	NIMA related kinase 2.	0.407
ATM	PNKP	ENSCHIP00000016363	ENSCHIP00000027908	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Polynucleotide kinase 3'-phosphatase.	0.515
ATM	POT1	ENSCHIP00000016363	ENSCHIP00000013444	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protection of telomeres 1.	0.402
ATM	XRCC5	ENSCHIP00000016363	ENSCHIP00000025197	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	X-ray repair cross complementing 5.	0.942
AURKB	NEK2	ENSCHIP00000026651	ENSCHIP00000005351	Aurora kinase B; Belongs to the protein kinase superfamily.	NIMA related kinase 2.	0.883
CCT2	CCT3	ENSCHIP00000031404	ENSCHIP00000008533	Chaperonin containing TCP1 subunit 2.	T-complex protein 1 subunit gamma.	0.999
CCT2	CCT4	ENSCHIP00000031404	ENSCHIP00000012390	Chaperonin containing TCP1 subunit 2.	T-complex protein 1 subunit delta.	0.999
CCT2	CCT5	ENSCHIP00000031404	ENSCHIP00000019052	Chaperonin containing TCP1 subunit 2.	Chaperonin containing TCP1 subunit 5.	0.999
CCT2	CCT6A	ENSCHIP00000031404	ENSCHIP00000015113	Chaperonin containing TCP1 subunit 2.	Uncharacterized protein.	0.985
CCT2	CCT7	ENSCHIP00000031404	ENSCHIP00000026590	Chaperonin containing TCP1 subunit 2.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.999
CCT2	ENSCHIP00000002380	ENSCHIP00000031404	ENSCHIP00000002380	Chaperonin containing TCP1 subunit 2.	Uncharacterized protein.	0.974
CCT2	ENSCHIP00000006258	ENSCHIP00000031404	ENSCHIP00000006258	Chaperonin containing TCP1 subunit 2.	Uncharacterized protein.	0.999
CCT2	ENSCHIP00000025330	ENSCHIP00000031404	ENSCHIP00000025330	Chaperonin containing TCP1 subunit 2.	Uncharacterized protein.	0.974
CCT2	LOC102170672	ENSCHIP00000031404	ENSCHIP00000022783	Chaperonin containing TCP1 subunit 2.	T-complex protein 1 subunit delta.	0.999
CCT2	LOC102174357	ENSCHIP00000031404	ENSCHIP00000027875	Chaperonin containing TCP1 subunit 2.	Uncharacterized protein.	0.974
CCT2	LOC102185345	ENSCHIP00000031404	ENSCHIP00000015903	Chaperonin containing TCP1 subunit 2.	Uncharacterized protein.	0.974
CCT2	LOC108635607	ENSCHIP00000031404	ENSCHIP00000023244	Chaperonin containing TCP1 subunit 2.	Uncharacterized protein.	0.974