(22 nodes) Negative regulation of chondrocyte differentiation network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NKX3-2	NK3 homeobox 2. (330 aa)
	RFLNB	Refilin B. (216 aa)
	CHADL	Chondroadherin like. (738 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	SNAI2	Snail family transcriptional repressor 2. (268 aa)
	LTBP3	Latent transforming growth factor beta binding protein 3. (1294 aa)
	RARG	Retinoic acid receptor gamma. (458 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
	SOX9	SRY-box transcription factor 9. (525 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	EFEMP1	EGF containing fibulin extracellular matrix protein 1. (498 aa)
	ADAMTS12	ADAM metallopeptidase with thrombospondin type 1 motif 12. (1605 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	RFLNA	Refilin A. (200 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	GLI3	GLI family zinc finger 3. (1614 aa)
	GDF5	Growth differentiation factor 5. (499 aa)
	CCN4	Cellular communication network factor 4. (368 aa)
	RARB	Retinoic acid receptor beta. (448 aa)
	GREM1	Gremlin. (184 aa)
	ADAMTS7	ADAM metallopeptidase with thrombospondin type 1 motif 7. (1677 aa)
	PTHLH	Parathyroid hormone-like protein. (177 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	CTNNB1	ENSCHIP00000023678	ENSCHIP00000031016	Bone morphogenetic protein 4.	Catenin beta 1.	0.800
BMP4	GDF5	ENSCHIP00000023678	ENSCHIP00000009728	Bone morphogenetic protein 4.	Growth differentiation factor 5.	0.530
BMP4	GLI3	ENSCHIP00000023678	ENSCHIP00000014153	Bone morphogenetic protein 4.	GLI family zinc finger 3.	0.499
BMP4	GREM1	ENSCHIP00000023678	ENSCHIP00000006985	Bone morphogenetic protein 4.	Gremlin.	0.946
BMP4	IHH	ENSCHIP00000023678	ENSCHIP00000016239	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.790
BMP4	SNAI2	ENSCHIP00000023678	ENSCHIP00000029179	Bone morphogenetic protein 4.	Snail family transcriptional repressor 2.	0.516
BMP4	SOX9	ENSCHIP00000023678	ENSCHIP00000024523	Bone morphogenetic protein 4.	SRY-box transcription factor 9.	0.769
BMP4	TGFBR1	ENSCHIP00000023678	ENSCHIP00000025782	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.799
CCN4	CTNNB1	ENSCHIP00000009471	ENSCHIP00000031016	Cellular communication network factor 4.	Catenin beta 1.	0.657
CTNNB1	BMP4	ENSCHIP00000031016	ENSCHIP00000023678	Catenin beta 1.	Bone morphogenetic protein 4.	0.800
CTNNB1	CCN4	ENSCHIP00000031016	ENSCHIP00000009471	Catenin beta 1.	Cellular communication network factor 4.	0.657
CTNNB1	GLI3	ENSCHIP00000031016	ENSCHIP00000014153	Catenin beta 1.	GLI family zinc finger 3.	0.581
CTNNB1	IHH	ENSCHIP00000031016	ENSCHIP00000016239	Catenin beta 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.680
CTNNB1	PTPN11	ENSCHIP00000031016	ENSCHIP00000020822	Catenin beta 1.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.413
CTNNB1	SNAI2	ENSCHIP00000031016	ENSCHIP00000029179	Catenin beta 1.	Snail family transcriptional repressor 2.	0.820
CTNNB1	SOX9	ENSCHIP00000031016	ENSCHIP00000024523	Catenin beta 1.	SRY-box transcription factor 9.	0.937
CTNNB1	TGFBR1	ENSCHIP00000031016	ENSCHIP00000025782	Catenin beta 1.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.630
GDF5	BMP4	ENSCHIP00000009728	ENSCHIP00000023678	Growth differentiation factor 5.	Bone morphogenetic protein 4.	0.530
GDF5	GREM1	ENSCHIP00000009728	ENSCHIP00000006985	Growth differentiation factor 5.	Gremlin.	0.917
GDF5	IHH	ENSCHIP00000009728	ENSCHIP00000016239	Growth differentiation factor 5.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.548