STRINGSTRING
MCM8 MCM8 DSCC1 DSCC1 ERCC3 ERCC3 WRNIP1 WRNIP1 PIF1 PIF1 POT1 POT1 DHX9 DHX9 DNA2 DNA2 RUVBL1 RUVBL1 DQX1 DQX1 LOC108638223 LOC108638223 MCM2 MCM2 HELQ HELQ MCM3 MCM3 CHD4 CHD4 RFC4 RFC4 ANXA1 ANXA1 CHD9 CHD9 GINS3 GINS3 MRE11 MRE11 XRCC5 XRCC5 CHD2 CHD2 MCMDC2 MCMDC2 ERCC2 ERCC2 ASCC3 ASCC3 RECQL RECQL RUVBL2 RUVBL2 DDX3X DDX3X ENSCHIP00000011218 ENSCHIP00000011218 WRN WRN CDC45 CDC45 ENSCHIP00000000025 ENSCHIP00000000025 SUPV3L1 SUPV3L1 DERPC DERPC CHD1 CHD1 ZRANB3 ZRANB3 CHD8 CHD8 RPA1 RPA1 DHX32 DHX32 NAV2 NAV2 RAD50 RAD50 TREX1 TREX1 SUB1 SUB1 CHTF18 CHTF18 RFC2 RFC2 PURA PURA RECQL5 RECQL5 RAD51 RAD51 GTF2F2 GTF2F2 MCM7 MCM7 HELB HELB ERCC6L ERCC6L BLM BLM TWNK TWNK UPF1 UPF1 DDX1 DDX1 RECQL4 RECQL4 NBN NBN MCM5 MCM5 IGHMBP2 IGHMBP2 CHD7 CHD7 RFC3 RFC3 XRCC6 XRCC6 C17orf64 C17orf64 SMARCAD1 SMARCAD1 MTERF1 MTERF1 CHD5 CHD5 FANCM FANCM LOC108634345 LOC108634345 DDX11 DDX11 G3BP1 G3BP1 SLFNL1 SLFNL1 BRIP1 BRIP1 FBH1 FBH1 GINS4 GINS4 TM4SF19 TM4SF19 GINS2 GINS2 CHD3 CHD3 DHX36 DHX36 MCM6 MCM6 CHD6 CHD6 MCM4 MCM4 MCM9 MCM9 ENSCHIP00000019473 ENSCHIP00000019473 ENSCHIP00000019703 ENSCHIP00000019703 ATRX ATRX POLQ POLQ CHD1L CHD1L RTEL1 RTEL1 SSBP1 SSBP1 ENSCHIP00000012571 ENSCHIP00000012571
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MCM8MCM domain-containing protein; Belongs to the MCM family. (832 aa)
DSCC1Uncharacterized protein. (388 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
WRNIP1WRN helicase interacting protein 1. (640 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (649 aa)
POT1Protection of telomeres 1. (785 aa)
DHX9DExH-box helicase 9. (1271 aa)
DNA2DNA replication helicase/nuclease 2. (1062 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
DQX1DEAQ-box RNA dependent ATPase 1. (719 aa)
LOC108638223Uncharacterized protein. (145 aa)
MCM2DNA helicase; Belongs to the MCM family. (1061 aa)
HELQHelicase, POLQ like. (1115 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
CHD4Uncharacterized protein. (1905 aa)
RFC4Replication factor C subunit 4. (364 aa)
ANXA1Annexin. (346 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2836 aa)
GINS3GINS complex subunit 3. (216 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (724 aa)
XRCC5X-ray repair cross complementing 5. (736 aa)
CHD2Uncharacterized protein. (1823 aa)
MCMDC2Minichromosome maintenance domain containing 2. (681 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
ASCC3Activating signal cointegrator 1 complex subunit 3. (2201 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (649 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (471 aa)
DDX3XUncharacterized protein; Belongs to the DEAD box helicase family. (661 aa)
ENSCHIP00000011218Uncharacterized protein. (167 aa)
WRNWRN RecQ like helicase. (1405 aa)
CDC45Cell division cycle 45. (524 aa)
ENSCHIP00000000025Uncharacterized protein. (552 aa)
SUPV3L1Suv3 like RNA helicase. (787 aa)
DERPCDERPC proline and glycine rich nuclear protein. (520 aa)
CHD1Chromodomain helicase DNA binding protein 1. (1711 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1070 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2583 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
DHX32DEAH-box helicase 32 (putative). (744 aa)
NAV2Neuron navigator 2. (2452 aa)
RAD50Zinc-hook domain-containing protein. (1332 aa)
TREX1Three prime repair exonuclease 1. (315 aa)
SUB1SUB1 regulator of transcription. (127 aa)
CHTF18Chromosome transmission fidelity factor 18. (948 aa)
RFC2Replication factor C subunit 2. (352 aa)
PURAPurine rich element binding protein A. (322 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
HELBDNA helicase B. (1077 aa)
ERCC6LERCC excision repair 6 like, spindle assembly checkpoint helicase. (1242 aa)
BLMBLM RecQ like helicase. (1429 aa)
TWNKTwinkle mtDNA helicase. (684 aa)
UPF1UPF1 RNA helicase and ATPase. (1126 aa)
DDX1DEAD-box helicase 1. (740 aa)
RECQL4RecQ like helicase 4. (1176 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
IGHMBP2Immunoglobulin mu DNA binding protein 2. (987 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2993 aa)
RFC3Replication factor C subunit 3. (356 aa)
XRCC6X-ray repair cross complementing 6. (607 aa)
C17orf64Chromosome 17 open reading frame 64. (234 aa)
SMARCAD1Uncharacterized protein. (1028 aa)
MTERF1Mitochondrial transcription termination factor 1. (397 aa)
CHD5Chromodomain helicase DNA binding protein 5. (1996 aa)
FANCMFA complementation group M. (2043 aa)
LOC108634345Uncharacterized protein. (206 aa)
DDX11DEAD/H-box helicase 11. (928 aa)
G3BP1G3BP stress granule assembly factor 1. (465 aa)
SLFNL1Schlafen like 1. (407 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1217 aa)
FBH1F-box DNA helicase 1. (1048 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
TM4SF19Uncharacterized protein. (202 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
CHD3Chromodomain helicase DNA binding protein 3. (1979 aa)
DHX36DEAH-box helicase 36. (1010 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
CHD6Chromodomain helicase DNA binding protein 6. (2720 aa)
MCM4DNA helicase; Belongs to the MCM family. (851 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1137 aa)
ENSCHIP00000019473Uncharacterized protein. (248 aa)
ENSCHIP00000019703Helicase ATP-binding domain-containing protein. (459 aa)
ATRXATRX chromatin remodeler. (2105 aa)
POLQDNA polymerase theta. (2587 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (893 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1212 aa)
SSBP1Uncharacterized protein. (148 aa)
ENSCHIP00000012571Uncharacterized protein. (386 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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