STRINGSTRING
RIPK2 RIPK2 TLR4 TLR4 CCL19 CCL19 ZBTB20 ZBTB20 THBS1 THBS1 MYD88 MYD88 PLCG2 PLCG2 HAVCR2 HAVCR2 IL12B IL12B ENSCHIP00000016994 ENSCHIP00000016994 LRRK2 LRRK2 PIK3R1 PIK3R1 SASH3 SASH3 STAT3 STAT3 CD84 CD84 IFIH1 IFIH1 LBP LBP LEP LEP PTPN11 PTPN11 NOD1 NOD1 ARHGEF2 ARHGEF2 TMEM106A TMEM106A C1QTNF4 C1QTNF4 FZD5 FZD5 FADD FADD AZU1 AZU1 CLEC7A CLEC7A RASGRP1 RASGRP1 IL23A IL23A DHX9 DHX9 CD14 CD14 SYK SYK LY96 LY96 FRMD8 FRMD8 CARD9 CARD9 AGER AGER CYBA CYBA TLR3 TLR3 HSPB1 HSPB1 WNT5A WNT5A MMP8 MMP8 MAPKAPK2 MAPKAPK2 RIPK1 RIPK1 APP APP ARID5A ARID5A TIRAP TIRAP DDX58 DDX58 LPL LPL PSEN1 PSEN1 NOD2 NOD2 TLR9 TLR9 SPHK2 SPHK2 NFATC4 NFATC4 ARFGEF2 ARFGEF2 SELENOK SELENOK LOC102186893 LOC102186893 CD2 CD2 PYCARD PYCARD EPHB2 EPHB2 SETD4 SETD4 ISL1 ISL1 PTPRC PTPRC IL17A IL17A
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (537 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
CCL19C-C motif chemokine. (102 aa)
ZBTB20Zinc finger and BTB domain containing 20. (751 aa)
THBS1Thrombospondin 1. (1218 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (331 aa)
ENSCHIP0000001699425A_SYNTH_3 domain-containing protein. (513 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CD84CD84 molecule. (349 aa)
IFIH1Interferon induced with helicase C domain 1. (1023 aa)
LBPLipopolysaccharide binding protein. (481 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (954 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (986 aa)
TMEM106ATransmembrane protein 106A. (261 aa)
C1QTNF4C1q and TNF related 4. (327 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (209 aa)
AZU1Azurocidin 1. (260 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
RASGRP1RAS guanyl releasing protein 1. (773 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
DHX9DExH-box helicase 9. (1271 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (373 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
LY96Lymphocyte antigen 96. (160 aa)
FRMD8FERM domain containing 8. (463 aa)
CARD9Caspase recruitment domain family member 9. (519 aa)
AGERAdvanced glycosylation end-product specific receptor. (416 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (191 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (918 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (201 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
MMP8Matrix metallopeptidase 8. (470 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (410 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (667 aa)
APPAmyloid beta precursor protein. (770 aa)
ARID5AAT-rich interaction domain 5A. (591 aa)
TIRAPTIR domain containing adaptor protein. (228 aa)
DDX58DExD/H-box helicase 58. (942 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (487 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (475 aa)
NOD2Uncharacterized protein. (982 aa)
TLR9TIR domain-containing protein. (1070 aa)
SPHK2Sphingosine kinase 2. (653 aa)
NFATC4Nuclear factor of activated T cells 4. (901 aa)
ARFGEF2ADP ribosylation factor guanine nucleotide exchange factor 2. (1786 aa)
SELENOKSelenoprotein K. (85 aa)
LOC102186893Uncharacterized protein. (709 aa)
CD2CD2 molecule. (338 aa)
PYCARDPYD and CARD domain containing. (196 aa)
EPHB2EPH receptor B2. (1016 aa)
SETD4SET domain containing 4. (440 aa)
ISL1ISL LIM homeobox 1. (349 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1067 aa)
IL17AInterleukin-17A. (153 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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