STRINGSTRING
GSK3A GSK3A RAF1 RAF1 NGF NGF IFNE IFNE LOC108636544 LOC108636544 SPRY2 SPRY2 LOC108634604 LOC108634604 LOC108636616 LOC108636616 CAV1 CAV1 LOC108635454 LOC108635454 HAX1 HAX1 LOC108635503 LOC108635503 ENSCHIP00000021158 ENSCHIP00000021158 OSM OSM SMYD3 SMYD3 BAG4 BAG4 EGFR EGFR RPTOR RPTOR PAK1 PAK1 LOC108633243 LOC108633243 LOC102180392 LOC102180392 LOC108636634 LOC108636634 BCAR3 BCAR3 LOC108635529 LOC108635529 LOC108636617 LOC108636617 ENSCHIP00000000908 ENSCHIP00000000908 LOC108634973 LOC108634973 TNF TNF LOC108636623 LOC108636623 TNKS1BP1 TNKS1BP1 IFNA IFNA VEGFA VEGFA NTF4 NTF4 LOC102174842 LOC102174842 ENSCHIP00000005465 ENSCHIP00000005465 LOC108636628 LOC108636628 EIF4G1 EIF4G1 LOC108635000 LOC108635000 LOC108636627 LOC108636627 HDAC6 HDAC6 LOC108636629 LOC108636629 AXIN1 AXIN1 LOC108636626 LOC108636626 LOC102181867 LOC102181867 AVP AVP NTRK3 NTRK3 RAPGEF3 RAPGEF3 SH2D3C SH2D3C LOC102180761 LOC102180761 MAD2L2 MAD2L2 LOC102188481 LOC102188481 LOC102189208 LOC102189208 TGFB1 TGFB1 LOC108636632 LOC108636632 SNCA SNCA NTF3 NTF3 STK4 STK4 LOC108636620 LOC108636620 MTCP1 MTCP1 LOC102181595 LOC102181595 SMYD3-2 SMYD3-2 TXN TXN ENSCHIP00000011351 ENSCHIP00000011351 ENSCHIP00000011995 ENSCHIP00000011995 LIF LIF ENSCHIP00000012937 ENSCHIP00000012937 CSF3 CSF3 AKAP9 AKAP9 TRIM6 TRIM6 GAS6 GAS6 ENSCHIP00000015031 ENSCHIP00000015031 WNT5A WNT5A PIK3CA PIK3CA WNT3A WNT3A BCL2 BCL2 IFNK IFNK OPRD1 OPRD1 IFNG IFNG CREBL2 CREBL2 ENSCHIP00000020611 ENSCHIP00000020611 LOC108635455 LOC108635455 LOC108633160 LOC108633160 RAMP3 RAMP3 RIPK2 RIPK2 BRAF BRAF ENSCHIP00000019035 ENSCHIP00000019035 CAMK1 CAMK1 PRKD1 PRKD1 FNIP2 FNIP2 LOC102179943 LOC102179943 BDNF BDNF FNIP1 FNIP1 PRKD2 PRKD2 GCG GCG STOX1 STOX1 IL11 IL11 PDCD10 PDCD10 TERF2IP TERF2IP CD44 CD44 RET RET LOC102176524 LOC102176524 PFN2 PFN2 PARK7 PARK7 ARAF ARAF DOCK7 DOCK7 SFRP2 SFRP2 TCL1B TCL1B NTRK2 NTRK2 AKT1 AKT1 PTGS2 PTGS2 ENSCHIP00000027417 ENSCHIP00000027417 ENSCHIP00000028617 ENSCHIP00000028617 LOC102179668 LOC102179668 ENSCHIP00000030196 ENSCHIP00000030196 SH2D3A SH2D3A ENSCHIP00000030908 ENSCHIP00000030908 NOS1 NOS1 ENSCHIP00000031025 ENSCHIP00000031025 PINK1 PINK1 UCN UCN CNOT9 CNOT9 HCLS1 HCLS1 APP APP MAPKAP1 MAPKAP1 LATS1 LATS1 TFRC TFRC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (241 aa)
IFNEInterferon epsilon. (193 aa)
LOC108636544Uncharacterized protein. (186 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
LOC108634604Uncharacterized protein. (195 aa)
LOC108636616Uncharacterized protein. (195 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
LOC108635454Uncharacterized protein. (195 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
LOC108635503Uncharacterized protein. (195 aa)
ENSCHIP00000021158Uncharacterized protein. (182 aa)
OSMOncostatin M. (239 aa)
SMYD3SET and MYND domain containing 3. (301 aa)
BAG4BAG domain-containing protein. (457 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1342 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
LOC108633243Uncharacterized protein. (186 aa)
LOC102180392Uncharacterized protein. (195 aa)
LOC108636634Uncharacterized protein. (186 aa)
BCAR3BCAR3 adaptor protein, NSP family member. (826 aa)
LOC108635529Uncharacterized protein. (189 aa)
LOC108636617Uncharacterized protein. (195 aa)
ENSCHIP00000000908Profilin; Belongs to the profilin family. (140 aa)
LOC108634973Uncharacterized protein. (195 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
LOC108636623Uncharacterized protein. (195 aa)
TNKS1BP1Tankyrase 1 binding protein 1. (1648 aa)
IFNAUncharacterized protein. (189 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (214 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
LOC102174842Uncharacterized protein. (189 aa)
ENSCHIP00000005465Uncharacterized protein. (168 aa)
LOC108636628Uncharacterized protein. (195 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1607 aa)
LOC108635000Uncharacterized protein. (195 aa)
LOC108636627Uncharacterized protein. (189 aa)
HDAC6Histone deacetylase 6. (988 aa)
LOC108636629Uncharacterized protein. (186 aa)
AXIN1Axin 1. (867 aa)
LOC108636626Uncharacterized protein. (195 aa)
LOC102181867Uncharacterized protein. (186 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (167 aa)
NTRK3Tyrosine-protein kinase receptor. (825 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (924 aa)
SH2D3CSH2 domain containing 3C. (860 aa)
LOC102180761Uncharacterized protein. (189 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (195 aa)
LOC102188481Uncharacterized protein. (379 aa)
LOC102189208Uncharacterized protein. (168 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
LOC108636632Uncharacterized protein. (186 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (266 aa)
STK4Serine/threonine kinase 4. (487 aa)
LOC108636620Uncharacterized protein. (195 aa)
MTCP1Mature T cell proliferation 1. (107 aa)
LOC102181595Uncharacterized protein. (186 aa)
SMYD3-2MYND-type domain-containing protein. (159 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
ENSCHIP00000011351Uncharacterized protein. (171 aa)
ENSCHIP00000011995Uncharacterized protein. (126 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
ENSCHIP00000012937Uncharacterized protein. (188 aa)
CSF3Colony stimulating factor 3. (226 aa)
AKAP9A-kinase anchoring protein 9. (3839 aa)
TRIM6Tripartite motif containing 6. (487 aa)
GAS6Growth arrest specific 6. (671 aa)
ENSCHIP00000015031Uncharacterized protein. (173 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
IFNKInterferon kappa. (205 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
CREBL2cAMP responsive element binding protein like 2. (130 aa)
ENSCHIP00000020611Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (291 aa)
LOC108635455Uncharacterized protein. (195 aa)
LOC108633160Uncharacterized protein. (189 aa)
RAMP3Receptor activity modifying protein 3. (147 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (537 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (774 aa)
ENSCHIP00000019035Uncharacterized protein. (191 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
FNIP2Folliculin interacting protein 2. (1104 aa)
LOC102179943Uncharacterized protein. (189 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (258 aa)
FNIP1Folliculin interacting protein 1. (1162 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
GCGGlucagon. (180 aa)
STOX1Storkhead box 1. (981 aa)
IL11Interleukin 11. (191 aa)
PDCD10Uncharacterized protein. (212 aa)
TERF2IPUncharacterized protein. (400 aa)
CD44CD44 molecule (Indian blood group). (715 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1118 aa)
LOC102176524Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1242 aa)
PFN2Profilin; Belongs to the profilin family. (140 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (611 aa)
DOCK7Dedicator of cytokinesis 7; Belongs to the DOCK family. (2117 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
TCL1BUncharacterized protein. (126 aa)
NTRK2Tyrosine-protein kinase receptor. (837 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
ENSCHIP00000027417Uncharacterized protein. (185 aa)
ENSCHIP00000028617Uncharacterized protein. (75 aa)
LOC102179668Uncharacterized protein. (191 aa)
ENSCHIP00000030196Uncharacterized protein. (144 aa)
SH2D3ASH2 domain containing 3A. (575 aa)
ENSCHIP00000030908BAG domain-containing protein. (427 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
ENSCHIP00000031025Uncharacterized protein. (171 aa)
PINK1PTEN induced kinase 1. (587 aa)
UCNUrocortin. (124 aa)
CNOT9CCR4-NOT transcription complex subunit 9. (299 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (471 aa)
APPAmyloid beta precursor protein. (770 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
LATS1Large tumor suppressor kinase 1. (1145 aa)
TFRCTransferrin receptor. (790 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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