(27 nodes) Regulation of intracellular estrogen receptor signaling pathway network (Capra hircus)

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Your Input:
	YAP1	Yes associated protein 1. (503 aa)
	FOXA1	Forkhead box A1. (468 aa)
	FSHR	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (670 aa)
	CNOT2	CCR4-NOT transcription complex subunit 2. (542 aa)
	AR	Androgen receptor. (891 aa)
	UBA5	Ubiquitin like modifier activating enzyme 5. (404 aa)
	KANK2	KN motif and ankyrin repeat domains 2. (858 aa)
	PHB2	Prohibitin. (289 aa)
	DNAAF4	Dynein axonemal assembly factor 4. (421 aa)
	UFL1	UFM1 specific ligase 1. (792 aa)
	FOXH1	Forkhead box H1. (360 aa)
	ENSCHIP00000014358	Uncharacterized protein. (90 aa)
	KMT2D	Lysine methyltransferase 2D. (5491 aa)
	ZNF366	Zinc finger protein 366. (742 aa)
	UFM1	Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached to substrate proteins as a monomer or a lysine-linked polymer in a post- translational process called ufmylation. Ufmylation on lysine residues of proteins may play a crucial role in a number of cellular processes. (85 aa)
	PAGR1	PAXIP1 associated glutamate rich protein 1. (254 aa)
	UFSP2	UFM1 specific peptidase 2. (469 aa)
	CNOT1	CCR4-NOT transcription complex subunit 1. (2376 aa)
	DDRGK1	DDRGK domain containing 1. (298 aa)
	SRC	Tyrosine-protein kinase. (538 aa)
	PAK1	Non-specific serine/threonine protein kinase. (544 aa)
	LATS1	Large tumor suppressor kinase 1. (1145 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
	CNOT9	CCR4-NOT transcription complex subunit 9. (299 aa)
	VPS18	VPS18 core subunit of CORVET and HOPS complexes. (973 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1577 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (681 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	BRCA1	ENSCHIP00000024342	ENSCHIP00000033014	Androgen receptor.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.741
AR	FOXA1	ENSCHIP00000024342	ENSCHIP00000027706	Androgen receptor.	Forkhead box A1.	0.935
AR	FSHR	ENSCHIP00000024342	ENSCHIP00000027680	Androgen receptor.	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.	0.563
AR	MED1	ENSCHIP00000024342	ENSCHIP00000028752	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.649
AR	SRC	ENSCHIP00000024342	ENSCHIP00000002619	Androgen receptor.	Tyrosine-protein kinase.	0.731
BRCA1	AR	ENSCHIP00000033014	ENSCHIP00000024342	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Androgen receptor.	0.741
BRCA1	FOXA1	ENSCHIP00000033014	ENSCHIP00000027706	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Forkhead box A1.	0.434
BRCA1	SRC	ENSCHIP00000033014	ENSCHIP00000002619	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Tyrosine-protein kinase.	0.409
CNOT1	CNOT2	ENSCHIP00000006752	ENSCHIP00000024469	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 2.	0.999
CNOT1	CNOT9	ENSCHIP00000006752	ENSCHIP00000032212	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 9.	0.999
CNOT2	CNOT1	ENSCHIP00000024469	ENSCHIP00000006752	CCR4-NOT transcription complex subunit 2.	CCR4-NOT transcription complex subunit 1.	0.999
CNOT2	CNOT9	ENSCHIP00000024469	ENSCHIP00000032212	CCR4-NOT transcription complex subunit 2.	CCR4-NOT transcription complex subunit 9.	0.999
CNOT9	CNOT1	ENSCHIP00000032212	ENSCHIP00000006752	CCR4-NOT transcription complex subunit 9.	CCR4-NOT transcription complex subunit 1.	0.999
CNOT9	CNOT2	ENSCHIP00000032212	ENSCHIP00000024469	CCR4-NOT transcription complex subunit 9.	CCR4-NOT transcription complex subunit 2.	0.999
DDRGK1	ENSCHIP00000014358	ENSCHIP00000005242	ENSCHIP00000014358	DDRGK domain containing 1.	Uncharacterized protein.	0.428
DDRGK1	UBA5	ENSCHIP00000005242	ENSCHIP00000023947	DDRGK domain containing 1.	Ubiquitin like modifier activating enzyme 5.	0.835
DDRGK1	UFL1	ENSCHIP00000005242	ENSCHIP00000016537	DDRGK domain containing 1.	UFM1 specific ligase 1.	0.979
DDRGK1	UFM1	ENSCHIP00000005242	ENSCHIP00000010350	DDRGK domain containing 1.	Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached to substrate proteins as a monomer or a lysine-linked polymer in a post- translational process called ufmylation. Ufmylation on lysine residues of proteins may play a crucial role in a number of cellular processes.	0.884
DDRGK1	UFSP2	ENSCHIP00000005242	ENSCHIP00000009614	DDRGK domain containing 1.	UFM1 specific peptidase 2.	0.679
DDRGK1	ZNF366	ENSCHIP00000005242	ENSCHIP00000010509	DDRGK domain containing 1.	Zinc finger protein 366.	0.431