43 items (Capra hircus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	CARD14	Caspase recruitment domain family member 14. (992 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	LOC102190074	IF rod domain-containing protein; Belongs to the intermediate filament family. (411 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (446 aa)
	STAT1	Signal transducer and activator of transcription. (834 aa)
	TNFSF13B	Tumor necrosis factor superfamily member 13b; Belongs to the tumor necrosis factor family. (280 aa)
	TNFRSF18	Uncharacterized protein. (243 aa)
	TRAF2	TNF receptor-associated factor. (497 aa)
	EDA2R	Ectodysplasin A2 receptor. (299 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	PIAS3	Protein inhibitor of activated STAT 3. (628 aa)
	UMOD	Uromodulin. (643 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (571 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member. (316 aa)
	TNFRSF17	TNF receptor superfamily member 17. (178 aa)
	ACTN4	Actinin alpha 4. (933 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
	FAS	Uncharacterized protein. (297 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (449 aa)
	TNFSF18	TNF superfamily member 18. (194 aa)
	TXNDC17	Thioredoxin domain containing 17. (123 aa)
	CD70	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (258 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
	TNFRSF13C	TNF receptor superfamily member 13C. (177 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (740 aa)
	CDIP1	Cell death inducing p53 target 1. (208 aa)
	ILK	Integrin linked kinase. (452 aa)
	FOXO3	Forkhead box O3. (672 aa)
	KRT8	Keratin 8; Belongs to the intermediate filament family. (484 aa)
	TRAF1	TNF receptor-associated factor. (410 aa)
	COMMD7	COMM domain-containing protein. (200 aa)
	TRAF3IP2	TRAF3 interacting protein 2. (572 aa)
	TNFRSF4	TNF receptor superfamily member 4. (278 aa)
	TNFRSF1B	TNF receptor superfamily member 1B. (459 aa)
	PLVAP	Plasmalemma vesicle associated protein. (449 aa)
	PYCARD	PYD and CARD domain containing. (196 aa)
	ENSCHIP00000027287	Uncharacterized protein. (130 aa)
	KRT18	IF rod domain-containing protein; Belongs to the intermediate filament family. (439 aa)
	CLDN18	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	TNFRSF11A	TNF receptor superfamily member 11a. (588 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARD14	TNFSF18	ENSCHIP00000030920	ENSCHIP00000008887	Caspase recruitment domain family member 14.	TNF superfamily member 18.	0.584
CARD14	TRAF3IP2	ENSCHIP00000030920	ENSCHIP00000021177	Caspase recruitment domain family member 14.	TRAF3 interacting protein 2.	0.507
CD70	TNF	ENSCHIP00000032781	ENSCHIP00000004561	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.567
CD70	TNFRSF18	ENSCHIP00000032781	ENSCHIP00000001378	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.504
CD70	TNFRSF4	ENSCHIP00000032781	ENSCHIP00000021531	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	TNF receptor superfamily member 4.	0.721
CD70	TNFSF18	ENSCHIP00000032781	ENSCHIP00000008887	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	TNF superfamily member 18.	0.490
CHUK	FOXO3	ENSCHIP00000017086	ENSCHIP00000019148	Component of inhibitor of nuclear factor kappa B kinase complex.	Forkhead box O3.	0.927
CHUK	IKBKB	ENSCHIP00000017086	ENSCHIP00000012487	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.999
CHUK	RELA	ENSCHIP00000017086	ENSCHIP00000013897	Component of inhibitor of nuclear factor kappa B kinase complex.	RELA proto-oncogene, NF-kB subunit.	0.992
CHUK	STAT1	ENSCHIP00000017086	ENSCHIP00000005767	Component of inhibitor of nuclear factor kappa B kinase complex.	Signal transducer and activator of transcription.	0.658
CHUK	TNF	ENSCHIP00000017086	ENSCHIP00000004561	Component of inhibitor of nuclear factor kappa B kinase complex.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.978
CHUK	TNFRSF1A	ENSCHIP00000017086	ENSCHIP00000010109	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor superfamily member 1A.	0.973
CHUK	TNFSF11	ENSCHIP00000017086	ENSCHIP00000013696	Component of inhibitor of nuclear factor kappa B kinase complex.	Tumor necrosis factor ligand superfamily member.	0.404
CHUK	TP53	ENSCHIP00000017086	ENSCHIP00000030141	Component of inhibitor of nuclear factor kappa B kinase complex.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.490
CHUK	TRAF1	ENSCHIP00000017086	ENSCHIP00000020875	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor.	0.798
CHUK	TRAF2	ENSCHIP00000017086	ENSCHIP00000002720	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor.	0.982
CHUK	TRAF3	ENSCHIP00000017086	ENSCHIP00000032520	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.817
CHUK	TRAF5	ENSCHIP00000017086	ENSCHIP00000016547	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.965
CHUK	TRAF6	ENSCHIP00000017086	ENSCHIP00000015162	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.991
EDA2R	TRAF3	ENSCHIP00000002783	ENSCHIP00000032520	Ectodysplasin A2 receptor.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.949