(16 nodes) Mammary gland epithelial cell proliferation network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CEBPB	CCAAT/enhancer-binding protein. (307 aa)
	IQGAP3	IQ motif containing GTPase activating protein 3. (1635 aa)
	ID2	BHLH domain-containing protein. (134 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1577 aa)
	STAT6	Signal transducer and activator of transcription. (841 aa)
	AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1191 aa)
	ENSCHIP00000003193	BHLH domain-containing protein. (122 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member. (316 aa)
	EPHA2	EPH receptor A2. (975 aa)
	AREG	Amphiregulin. (264 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
	PHB2	Prohibitin. (289 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AREG	CCND1	ENSCHIP00000015057	ENSCHIP00000006815	Amphiregulin.	Cyclin D1; Belongs to the cyclin family.	0.463
AREG	ESR1	ENSCHIP00000015057	ENSCHIP00000012243	Amphiregulin.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.590
CCND1	AREG	ENSCHIP00000006815	ENSCHIP00000015057	Cyclin D1; Belongs to the cyclin family.	Amphiregulin.	0.463
CCND1	ESR1	ENSCHIP00000006815	ENSCHIP00000012243	Cyclin D1; Belongs to the cyclin family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.929
CCND1	MAPK1	ENSCHIP00000006815	ENSCHIP00000000204	Cyclin D1; Belongs to the cyclin family.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.609
CCND1	STAT6	ENSCHIP00000006815	ENSCHIP00000031225	Cyclin D1; Belongs to the cyclin family.	Signal transducer and activator of transcription.	0.589
CCND1	WNT5A	ENSCHIP00000006815	ENSCHIP00000015533	Cyclin D1; Belongs to the cyclin family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.687
CEBPB	ESR1	ENSCHIP00000032035	ENSCHIP00000012243	CCAAT/enhancer-binding protein.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.655
CEBPB	MAPK1	ENSCHIP00000032035	ENSCHIP00000000204	CCAAT/enhancer-binding protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.878
CEBPB	STAT6	ENSCHIP00000032035	ENSCHIP00000031225	CCAAT/enhancer-binding protein.	Signal transducer and activator of transcription.	0.475
ESR1	AREG	ENSCHIP00000012243	ENSCHIP00000015057	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Amphiregulin.	0.590
ESR1	CCND1	ENSCHIP00000012243	ENSCHIP00000006815	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Cyclin D1; Belongs to the cyclin family.	0.929
ESR1	CEBPB	ENSCHIP00000012243	ENSCHIP00000032035	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	CCAAT/enhancer-binding protein.	0.655
ESR1	MAPK1	ENSCHIP00000012243	ENSCHIP00000000204	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.955
ESR1	MED1	ENSCHIP00000012243	ENSCHIP00000028752	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.986
ESR1	PHB2	ENSCHIP00000012243	ENSCHIP00000017241	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Prohibitin.	0.817
ESR1	STAT6	ENSCHIP00000012243	ENSCHIP00000031225	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Signal transducer and activator of transcription.	0.484
MAPK1	CCND1	ENSCHIP00000000204	ENSCHIP00000006815	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Cyclin D1; Belongs to the cyclin family.	0.609
MAPK1	CEBPB	ENSCHIP00000000204	ENSCHIP00000032035	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	CCAAT/enhancer-binding protein.	0.878
MAPK1	ESR1	ENSCHIP00000000204	ENSCHIP00000012243	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.955