STRINGSTRING
LOC102172689 LOC102172689 NXT2 NXT2 ENSCHIP00000000814 ENSCHIP00000000814 LOC108635911 LOC108635911 INTS13 INTS13 STK4 STK4 PPP3R1 PPP3R1 HNRNPU HNRNPU CDKN1A CDKN1A HHEX HHEX TAF3 TAF3 CTDNEP1 CTDNEP1 RANBP6 RANBP6 LOC108637516 LOC108637516 CIZ1 CIZ1 ENSCHIP00000003851 ENSCHIP00000003851 LOC102169090 LOC102169090 IPO13 IPO13 NUP62CL NUP62CL PML PML RRS1 RRS1 IPO4 IPO4 NOP53 NOP53 SUPT7L SUPT7L BMP7 BMP7 SIX2 SIX2 OSBPL8 OSBPL8 XPA XPA APPL2 APPL2 E2F3 E2F3 STK3 STK3 NF1 NF1 ENSCHIP00000007700 ENSCHIP00000007700 ATF2 ATF2 ENSCHIP00000008369 ENSCHIP00000008369 PAF1 PAF1 TNPO3 TNPO3 TNPO2 TNPO2 NUP62 NUP62 SYK SYK ARL2BP ARL2BP SIX4 SIX4 PRICKLE1 PRICKLE1 RANBP2 RANBP2 TOPORS TOPORS FAM53B FAM53B TMCO6 TMCO6 TOR1AIP2 TOR1AIP2 IPO11 IPO11 RAP1GDS1 RAP1GDS1 SUN1 SUN1 LMNB2 LMNB2 SHISA4 SHISA4 TXN TXN GPN2 GPN2 LMNB1 LMNB1 GPN3 GPN3 MSX1 MSX1 PLRG1 PLRG1 ELAVL1 ELAVL1 TPR TPR BANP BANP KPNB1 KPNB1 WRN WRN BBS4 BBS4 DVL1 DVL1 SEC13 SEC13 GLI3 GLI3 IPO9 IPO9 TOR1B TOR1B WRAP53 WRAP53 KPNA6 KPNA6 BCL3 BCL3 SYNE1 SYNE1 EIF4ENIF1 EIF4ENIF1 ENSCHIP00000016214 ENSCHIP00000016214 CSE1L CSE1L HEATR3 HEATR3 SPG11 SPG11 NUP155 NUP155 PHB2 PHB2 NUP188 NUP188 TXNIP TXNIP NUP85 NUP85 ENSCHIP00000018557 ENSCHIP00000018557 APPL1 APPL1 SNUPN SNUPN IPO5 IPO5 TAF8 TAF8 XPO1 XPO1 ENSCHIP00000020495 ENSCHIP00000020495 ENSCHIP00000021059 ENSCHIP00000021059 TRAF3IP2 TRAF3IP2 SPRN SPRN NR5A1 NR5A1 ENSCHIP00000021944 ENSCHIP00000021944 LOC108635156 LOC108635156 STAT3 STAT3 TOR1A TOR1A KPNA3 KPNA3 ENSCHIP00000022555 ENSCHIP00000022555 RPL11 RPL11 TBRG1 TBRG1 FGF9 FGF9 AKIRIN2 AKIRIN2 PTTG1IP PTTG1IP FAM53C FAM53C ENSCHIP00000023585 ENSCHIP00000023585 BMP4 BMP4 NOTCH1 NOTCH1 PIK3R1 PIK3R1 ARL2 ARL2 COL1A1 COL1A1 POLA2 POLA2 SOX9 SOX9 STK11 STK11 UTP25 UTP25 LRRK2 LRRK2 NUP93 NUP93 CNEP1R1 CNEP1R1 PARK7 PARK7 IPO8 IPO8 RPF2 RPF2 LOC102181259 LOC102181259 ZBTB7A ZBTB7A LMNA LMNA PYGO2 PYGO2 PLK1 PLK1 SQSTM1 SQSTM1 ENSCHIP00000026982 ENSCHIP00000026982 NUP35 NUP35 SMO SMO ABCA7 ABCA7 YWHAE YWHAE AKT1 AKT1 NUP88 NUP88 LOC102189480 LOC102189480 CALR CALR TNPO1 TNPO1 SHH SHH CRY2 CRY2 HIKESHI HIKESHI NUP153 NUP153 ING1 ING1 NOL8 NOL8 GBP2 GBP2 ABRA ABRA LOC108637868 LOC108637868 MED1 MED1 CLDN18 CLDN18 IPO7 IPO7 SIX1 SIX1 PYGO1 PYGO1 NUTF2 NUTF2 TP53 TP53 RANGRF RANGRF KPNA5 KPNA5 ENSCHIP00000030705 ENSCHIP00000030705 LOC108636030 LOC108636030 CDK5 CDK5 NUP50 NUP50 RPAIN RPAIN TOR1AIP1 TOR1AIP1 NUP214 NUP214 NUP133 NUP133 KPNA7 KPNA7 ENSCHIP00000032340 ENSCHIP00000032340 RANGAP1 RANGAP1 PINX1 PINX1 KPNA1 KPNA1 PPP3CA PPP3CA MMP12 MMP12 KPNA2 KPNA2 RRP7A RRP7A NUP107 NUP107 ENSCHIP00000033291 ENSCHIP00000033291 KPNA4 KPNA4 NUP54 NUP54
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102172689Importin subunit alpha; Functions in nuclear protein import. (529 aa)
NXT2Nuclear transport factor 2 like export factor 2. (197 aa)
ENSCHIP00000000814GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (167 aa)
LOC108635911GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (216 aa)
INTS13Integrator complex subunit 13. (706 aa)
STK4Serine/threonine kinase 4. (487 aa)
PPP3R1Uncharacterized protein. (170 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (806 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
HHEXHematopoietically expressed homeobox. (271 aa)
TAF3TATA-box binding protein associated factor 3. (921 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (244 aa)
RANBP6RAN binding protein 6. (1105 aa)
LOC108637516GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (216 aa)
CIZ1CDKN1A interacting zinc finger protein 1. (842 aa)
ENSCHIP00000003851Uncharacterized protein. (629 aa)
LOC102169090Uncharacterized protein. (403 aa)
IPO13Importin 13. (963 aa)
NUP62CLNsp1_C domain-containing protein. (304 aa)
PMLPromyelocytic leukemia. (868 aa)
RRS1Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (365 aa)
IPO4Importin 4. (1120 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (479 aa)
SUPT7LSPT7 like, STAGA complex gamma subunit. (412 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SIX2SIX homeobox 2. (296 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (902 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (662 aa)
E2F3E2F_TDP domain-containing protein. (460 aa)
STK3Serine/threonine kinase 3. (495 aa)
NF1Neurofibromin 1. (2848 aa)
ENSCHIP00000007700Uncharacterized protein. (385 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ENSCHIP00000008369IBB domain-containing protein. (87 aa)
PAF1Uncharacterized protein. (501 aa)
TNPO3Transportin 3. (923 aa)
TNPO2Transportin 2. (885 aa)
NUP62Nucleoporin 62. (523 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
ARL2BPARL2_Bind_BART domain-containing protein. (146 aa)
SIX4SIX homeobox 4. (784 aa)
PRICKLE1Prickle planar cell polarity protein 1. (834 aa)
RANBP2RAN binding protein 2. (3077 aa)
TOPORSTOP1 binding arginine/serine rich protein. (1034 aa)
FAM53BUncharacterized protein. (408 aa)
TMCO6Transmembrane and coiled-coil domains 6. (532 aa)
TOR1AIP2Torsin 1A interacting protein 2. (469 aa)
IPO11Importin 11. (975 aa)
RAP1GDS1Rap1 GTPase-GDP dissociation stimulator 1. (608 aa)
SUN1Sad1 and UNC84 domain containing 1. (889 aa)
LMNB2Lamin B2; Belongs to the intermediate filament family. (641 aa)
SHISA4Shisa family member 4. (243 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
GPN2GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (310 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (586 aa)
GPN3GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (284 aa)
MSX1Msh homeobox 1. (303 aa)
PLRG1Pleiotropic regulator 1. (514 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
TPRTranslocated promoter region, nuclear basket protein. (2436 aa)
BANPBTG3 associated nuclear protein. (503 aa)
KPNB1Karyopherin subunit beta 1. (877 aa)
WRNWRN RecQ like helicase. (1405 aa)
BBS4Bardet-Biedl syndrome 4. (519 aa)
DVL1Dishevelled segment polarity protein 1. (682 aa)
SEC13WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family. (322 aa)
GLI3GLI family zinc finger 3. (1614 aa)
IPO9Importin 9. (1041 aa)
TOR1BTorsin. (336 aa)
WRAP53WD repeat containing antisense to TP53. (540 aa)
KPNA6Importin subunit alpha; Functions in nuclear protein import. (536 aa)
BCL3BCL3 transcription coactivator. (454 aa)
SYNE1Spectrin repeat containing nuclear envelope protein 1. (8801 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (984 aa)
ENSCHIP0000001621414_3_3 domain-containing protein; Belongs to the 14-3-3 family. (217 aa)
CSE1LChromosome segregation 1 like. (971 aa)
HEATR3HEAT repeat containing 3. (679 aa)
SPG11SPG11 vesicle trafficking associated, spatacsin. (2432 aa)
NUP155Nucleoporin 155. (1391 aa)
PHB2Prohibitin. (289 aa)
NUP188Nucleoporin 188. (1751 aa)
TXNIPThioredoxin interacting protein. (391 aa)
NUP85Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (656 aa)
ENSCHIP00000018557Uncharacterized protein. (90 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (705 aa)
SNUPNSnurportin-1; Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. Belongs to the snurportin family. (362 aa)
IPO5Importin 5. (1097 aa)
TAF8TATA-box binding protein associated factor 8. (310 aa)
XPO1Exportin 1. (1071 aa)
ENSCHIP00000020495Uncharacterized protein. (265 aa)
ENSCHIP00000021059Uncharacterized protein. (63 aa)
TRAF3IP2TRAF3 interacting protein 2. (572 aa)
SPRNShadow of prion protein. (146 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
ENSCHIP00000021944ARL2_Bind_BART domain-containing protein. (139 aa)
LOC108635156WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family. (274 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
TOR1ATorsin. (333 aa)
KPNA3Importin subunit alpha; Functions in nuclear protein import. (521 aa)
ENSCHIP00000022555ARL2_Bind_BART domain-containing protein. (152 aa)
RPL11Uncharacterized protein; Belongs to the universal ribosomal protein uL5 family. (178 aa)
TBRG1Transforming growth factor beta regulator 1. (411 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
AKIRIN2Akirin 2. (222 aa)
PTTG1IPPTTG1 interacting protein. (150 aa)
FAM53CFamily with sequence similarity 53 member C. (392 aa)
ENSCHIP00000023585E2F_TDP domain-containing protein. (403 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
NOTCH1Notch receptor 1. (2508 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ARL2ARL2-SNX15 readthrough (NMD candidate); Belongs to the small GTPase superfamily. Arf family. (184 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (603 aa)
SOX9SRY-box transcription factor 9. (525 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
UTP25UTP25 small subunit processor component. (812 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
NUP93Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (819 aa)
CNEP1R1CTD nuclear envelope phosphatase 1 regulatory subunit 1. (125 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
IPO8Importin 8. (1009 aa)
RPF2Ribosome production factor 2 homolog. (296 aa)
LOC102181259Uncharacterized protein. (1216 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (602 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (665 aa)
PYGO2Pygopus family PHD finger 2. (392 aa)
PLK1Serine/threonine-protein kinase PLK. (602 aa)
SQSTM1Sequestosome 1. (440 aa)
ENSCHIP00000026982Uncharacterized protein; Belongs to the universal ribosomal protein uL5 family. (173 aa)
NUP35Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family. (310 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
ABCA7ATP binding cassette subfamily A member 7. (2152 aa)
YWHAE14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (243 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
NUP88Uncharacterized protein. (755 aa)
LOC102189480Uncharacterized protein; Belongs to the universal ribosomal protein uL5 family. (163 aa)
CALRCalreticulin. (417 aa)
TNPO1Transportin 1. (898 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
CRY2Cryptochrome circadian regulator 2. (596 aa)
HIKESHIHeat shock protein nuclear import factor hikeshi. (197 aa)
NUP153Nucleoporin 153. (1478 aa)
ING1Inhibitor of growth protein. (278 aa)
NOL8Nucleolar protein 8. (1162 aa)
GBP2Guanylate binding protein 2. (508 aa)
ABRAActin binding Rho activating protein. (382 aa)
LOC108637868GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (209 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1577 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
IPO7Importin 7. (1038 aa)
SIX1SIX homeobox 1. (284 aa)
PYGO1Pygopus family PHD finger 1. (412 aa)
NUTF2NTF2 domain-containing protein. (127 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
RANGRFRAN guanine nucleotide release factor. (186 aa)
KPNA5Importin subunit alpha; Functions in nuclear protein import. (539 aa)
ENSCHIP0000003070514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (206 aa)
LOC108636030GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (196 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
NUP50Nucleoporin 50. (465 aa)
RPAINRPA interacting protein. (219 aa)
TOR1AIP1Torsin 1A interacting protein 1. (615 aa)
NUP214Nucleoporin 214. (2043 aa)
NUP133Nucleoporin 133. (1156 aa)
KPNA7Importin subunit alpha; Functions in nuclear protein import. (522 aa)
ENSCHIP00000032340NTF2 domain-containing protein. (107 aa)
RANGAP1Ran GTPase activating protein 1. (585 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (312 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (538 aa)
PPP3CASerine/threonine-protein phosphatase. (527 aa)
MMP12Matrix metallopeptidase 12. (470 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (495 aa)
RRP7ARibosomal RNA processing 7 homolog A. (280 aa)
NUP107Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (925 aa)
ENSCHIP00000033291Uncharacterized protein. (197 aa)
KPNA4Importin subunit alpha; Functions in nuclear protein import. (509 aa)
NUP54Nucleoporin 54. (510 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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