STRINGSTRING
ARX ARX JARID2 JARID2 PSAP PSAP PSAPL1 PSAPL1 STK4 STK4 PLAG1 PLAG1 SMAD1 SMAD1 ATF2 ATF2 TGFBR2 TGFBR2 PRKAR1A PRKAR1A RARB RARB ENSCHIP00000009938 ENSCHIP00000009938 FGF10 FGF10 SAV1 SAV1 IL7 IL7 EHMT2 EHMT2 ESR1 ESR1 HLX HLX ZMPSTE24 ZMPSTE24 RARA RARA TMEM38B TMEM38B ENSCHIP00000013896 ENSCHIP00000013896 COMP COMP FGF7 FGF7 SDC3 SDC3 ADPRHL1 ADPRHL1 EVC EVC IFT80 IFT80 BNC2 BNC2 BMP10 BMP10 ENSCHIP00000032619 ENSCHIP00000032619 HEY2 HEY2 TENM4 TENM4 THBS3 THBS3 BCL2 BCL2 ANXA6 ANXA6 CER1 CER1 FGF8 FGF8 YAP1 YAP1 UBE3A UBE3A MAPK11 MAPK11 GATA6 GATA6 DIPK2A DIPK2A FXN FXN PTPN11 PTPN11 LEP LEP SMPD3 SMPD3 SMAD2 SMAD2 FGF9 FGF9 DLL1 DLL1 ADRA1A ADRA1A MMP13 MMP13 OSTN OSTN NOTCH1 NOTCH1 NPPC NPPC AR AR SOX9 SOX9 DDR2 DDR2 GJE1 GJE1 TGFB2 TGFB2 LOC102175492 LOC102175492 LEPR LEPR RARG RARG SHH SHH TBX5 TBX5 ADPRH ADPRH ENSCHIP00000029297 ENSCHIP00000029297 WNT2 WNT2 ECM1 ECM1 ARID2 ARID2 STK3 STK3 EXT1 EXT1 RAG2 RAG2 S1PR1 S1PR1 SPRY2 SPRY2 MATN1 MATN1 MESP1 MESP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARXAristaless related homeobox. (564 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1258 aa)
PSAPProsaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (525 aa)
PSAPL1Prosaposin like 1 (gene/pseudogene). (537 aa)
STK4Serine/threonine kinase 4. (487 aa)
PLAG1PLAG1 zinc finger. (499 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (380 aa)
RARBRetinoic acid receptor beta. (448 aa)
ENSCHIP00000009938Annexin. (100 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
IL7Interleukin 7. (181 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1268 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
HLXH2.0 like homeobox. (488 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
RARARetinoic acid receptor alpha. (462 aa)
TMEM38BTransmembrane protein 38B. (291 aa)
ENSCHIP00000013896Uncharacterized protein. (179 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
SDC3Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (442 aa)
ADPRHL1ADP-ribosylhydrolase like 1. (354 aa)
EVCEvC ciliary complex subunit 1. (993 aa)
IFT80Intraflagellar transport 80. (771 aa)
BNC2Basonuclin 2. (1107 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
ENSCHIP00000032619ANK_REP_REGION domain-containing protein. (266 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
TENM4Teneurin transmembrane protein 4. (2855 aa)
THBS3Thrombospondin 3. (984 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
ANXA6Annexin. (689 aa)
CER1Cerberus 1, DAN family BMP antagonist. (263 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
YAP1Yes associated protein 1. (503 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (875 aa)
MAPK11Mitogen-activated protein kinase. (417 aa)
GATA6GATA binding protein 6. (592 aa)
DIPK2ADivergent protein kinase domain 2A. (430 aa)
FXNFrataxin. (217 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
ADRA1AAdrenoceptor alpha 1A. (466 aa)
MMP13Matrix metallopeptidase 13. (472 aa)
OSTNOsteocrin. (132 aa)
NOTCH1Notch receptor 1. (2508 aa)
NPPCNatriuretic peptide C. (126 aa)
ARAndrogen receptor. (891 aa)
SOX9SRY-box transcription factor 9. (525 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (889 aa)
GJE1Gap junction protein epsilon 1. (205 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LOC102175492ANK_REP_REGION domain-containing protein. (1589 aa)
LEPRLeptin receptor. (1166 aa)
RARGRetinoic acid receptor gamma. (458 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
TBX5T-box transcription factor 5. (594 aa)
ADPRHADP-ribosylarginine hydrolase. (354 aa)
ENSCHIP00000029297Syndecan domain-containing protein. (407 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ECM1Extracellular matrix protein 1. (524 aa)
ARID2AT-rich interaction domain 2. (1835 aa)
STK3Serine/threonine kinase 3. (495 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (446 aa)
RAG2Recombination activating 2. (527 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
MATN1Matrilin 1. (480 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (256 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
Server load: low (30%) [HD]