STRINGSTRING
RNF169 RNF169 HELB HELB SAMHD1 SAMHD1 CNTD1 CNTD1 ENSCHIP00000033297 ENSCHIP00000033297 ACTR3B ACTR3B RAD51 RAD51 SIRT6 SIRT6 ENSCHIP00000031547 ENSCHIP00000031547 INTS3 INTS3 ENSCHIP00000031435 ENSCHIP00000031435 NABP1 NABP1 SMARCAL1 SMARCAL1 TP53 TP53 HUS1 HUS1 WAS WAS ARPC3 ARPC3 PNKP PNKP RPA3 RPA3 RNF168 RNF168 PHF1 PHF1 LMNA LMNA ZBTB7A ZBTB7A MRE11 MRE11 SLF2 SLF2 RIF1 RIF1 RPA2 RPA2 CGAS CGAS PRPF19 PRPF19 VCP VCP PARP1 PARP1 SMC5 SMC5 ARPC5 ARPC5 UFL1 UFL1 SIRT7 SIRT7 LOC108637664 LOC108637664 INIP INIP TONSL TONSL PARP3 PARP3 XRCC4 XRCC4 ACTR3 ACTR3 WRAP53 WRAP53 ARPC4 ARPC4 NABP2 NABP2 SLF1 SLF1 APLF APLF DDB1 DDB1 SHLD1 SHLD1 NHEJ1 NHEJ1 RFWD3 RFWD3 SMARCA5 SMARCA5 ENSCHIP00000010891 ENSCHIP00000010891 RBBP8 RBBP8 SMARCAD1 SMARCAD1 ESCO2 ESCO2 FAM178B FAM178B REC114 REC114 WDR70 WDR70 ATF2 ATF2 LOC102168811 LOC102168811 NBN NBN TIMELESS TIMELESS POLH POLH TP53BP1 TP53BP1 SMC6 SMC6 ZGRF1 ZGRF1 RAD18 RAD18 ARPC2 ARPC2 RNF8 RNF8 PAXX PAXX RAD50 RAD50 ENSCHIP00000002654 ENSCHIP00000002654 LOC108634517 LOC108634517 POLL POLL ENSCHIP00000001384 ENSCHIP00000001384 LOC102177756 LOC102177756 SMCHD1 SMCHD1 SHLD2 SHLD2 ENSCHIP00000000047 ENSCHIP00000000047
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RNF169Ring finger protein 169. (708 aa)
HELBDNA helicase B. (1077 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (606 aa)
CNTD1Cyclin N-terminal domain containing 1. (339 aa)
ENSCHIP00000033297Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (165 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (418 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
SIRT6Sirtuin 6. (335 aa)
ENSCHIP00000031547HTH_48 domain-containing protein. (342 aa)
INTS3Integrator complex subunit 3. (1041 aa)
ENSCHIP00000031435Uncharacterized protein. (77 aa)
NABP1Nucleic acid binding protein 1. (205 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (930 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
WASWASP actin nucleation promoting factor. (536 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (194 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (522 aa)
RPA3Uncharacterized protein. (121 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa)
PHF1PHD finger protein 1. (567 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (665 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (602 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (724 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1167 aa)
RIF1Replication timing regulatory factor 1. (2486 aa)
RPA2Replication protein A2. (270 aa)
CGASCyclic GMP-AMP synthase. (511 aa)
PRPF19Pre-mRNA processing factor 19. (504 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (816 aa)
PARP1Poly [ADP-ribose] polymerase. (1020 aa)
SMC5AAA_23 domain-containing protein. (1104 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
UFL1UFM1 specific ligase 1. (792 aa)
SIRT7Sirtuin 7. (405 aa)
LOC108637664Uncharacterized protein. (1041 aa)
INIPINTS3 and NABP interacting protein. (102 aa)
TONSLTonsoku like, DNA repair protein. (1371 aa)
PARP3Poly [ADP-ribose] polymerase. (525 aa)
XRCC4X-ray repair cross complementing 4. (332 aa)
ACTR3Uncharacterized protein; Belongs to the actin family. (405 aa)
WRAP53WD repeat containing antisense to TP53. (540 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (178 aa)
NABP2Nucleic acid binding protein 2. (175 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1056 aa)
APLFAprataxin and PNKP like factor. (480 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
SHLD1Shieldin complex subunit 1. (206 aa)
NHEJ1Non-homologous end joining factor 1. (299 aa)
RFWD3Ring finger and WD repeat domain 3. (791 aa)
SMARCA5Uncharacterized protein. (1052 aa)
ENSCHIP00000010891Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (116 aa)
RBBP8RB binding protein 8, endonuclease. (889 aa)
SMARCAD1Uncharacterized protein. (1028 aa)
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2. (610 aa)
FAM178BFamily with sequence similarity 178 member B. (699 aa)
REC114REC114 meiotic recombination protein. (252 aa)
WDR70WD repeat domain 70. (652 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
LOC102168811Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (289 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
TIMELESSTimeless circadian regulator. (1206 aa)
POLHDNA polymerase eta. (733 aa)
TP53BP1Tumor protein p53 binding protein 1. (1966 aa)
SMC6Structural maintenance of chromosomes 6. (1116 aa)
ZGRF1Uncharacterized protein. (1855 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (502 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (303 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (504 aa)
PAXXPAXX non-homologous end joining factor. (201 aa)
RAD50Zinc-hook domain-containing protein. (1332 aa)
ENSCHIP00000002654Uncharacterized protein. (121 aa)
LOC108634517Uncharacterized protein; Belongs to the actin family. (214 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (594 aa)
ENSCHIP00000001384Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (237 aa)
LOC102177756HTH_48 domain-containing protein. (337 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (1987 aa)
SHLD2Shieldin complex subunit 2. (918 aa)
ENSCHIP00000000047RING-type domain-containing protein. (101 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.