STRINGSTRING
LEP LEP NGFR NGFR LRP2 LRP2 EGR2 EGR2 SEC24B SEC24B HECTD1 HECTD1 HES1 HES1 NDST1 NDST1 FGF8 FGF8 FOXH1 FOXH1 DLL4 DLL4 TAB1 TAB1 DCTN5 DCTN5 TBX2 TBX2 NPRL3 NPRL3 SMAD6 SMAD6 PRICKLE1 PRICKLE1 SNX17 SNX17 SRF SRF CHD7 CHD7 NKX3-1 NKX3-1 PLXND1 PLXND1 TFAP2B TFAP2B ACVRL1 ACVRL1 HEY2 HEY2 ENG ENG SIX1 SIX1 ADAMTS6 ADAMTS6 APLNR APLNR PRDM1 PRDM1 EYA1 EYA1 ENSCHIP00000003122 ENSCHIP00000003122 ENSCHIP00000001052 ENSCHIP00000001052 ENSCHIP00000000870 ENSCHIP00000000870 BMPR1A BMPR1A SUFU SUFU ENSCHIP00000024963 ENSCHIP00000024963 FKBP10 FKBP10 LOXL1 LOXL1 PROX1 PROX1 JAG1 JAG1 PKD2 PKD2 EDNRA EDNRA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
NGFRNerve growth factor receptor. (427 aa)
LRP2LDL receptor related protein 2. (4649 aa)
EGR2Early growth response 2. (472 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1261 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
NDST1N-deacetylase and N-sulfotransferase 1. (882 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
FOXH1Forkhead box H1. (360 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (701 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
DCTN5Uncharacterized protein. (182 aa)
TBX2T-box transcription factor 2. (771 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (569 aa)
SMAD6Mothers against decapentaplegic homolog. (497 aa)
PRICKLE1Prickle planar cell polarity protein 1. (834 aa)
SNX17Sorting nexin 17. (470 aa)
SRFSerum response factor. (509 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2993 aa)
NKX3-1NK3 homeobox 1. (239 aa)
PLXND1Plexin D1. (1926 aa)
TFAP2BTranscription factor AP-2 beta. (476 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
ENGEndoglin. (649 aa)
SIX1SIX homeobox 1. (284 aa)
ADAMTS6ADAM metallopeptidase with thrombospondin type 1 motif 6. (1117 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
PRDM1PR/SET domain 1. (851 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
ENSCHIP00000003122SNX17_FERM_C domain-containing protein. (205 aa)
ENSCHIP00000001052Uncharacterized protein. (65 aa)
ENSCHIP00000000870Ig-like domain-containing protein. (132 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
ENSCHIP00000024963Uncharacterized protein. (163 aa)
FKBP10Peptidylprolyl isomerase. (574 aa)
LOXL1Lysyl oxidase like 1. (592 aa)
PROX1Prospero homeobox 1. (734 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (978 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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